product summary
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company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
TCR beta Monoclonal Antibody (H57-597)
catalog :
MA1-70045
quantity :
250 µg
price :
US 365.00
clonality :
monoclonal
host :
hamsters
conjugate :
nonconjugated
clone name :
H57-597
reactivity :
mouse
application :
western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry, immunohistochemistry - frozen section, other
more info or order :
citations: 122
Published Application/Species/Sample/DilutionReference
  • immunohistochemistry - frozen section; mouse; 1:50; loading ...; fig 5a
  • flow cytometry; mouse; loading ...; fig 3a
Costain A, Phythian Adams A, Colombo S, Marley A, Owusu C, Cook P, et al. Dynamics of Host Immune Response Development During Schistosoma mansoni Infection. Front Immunol. 2022;13:906338 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 7a
Huang C, Schuring J, Skinner J, Mok L, Chong M. MYL9 deficiency is neonatal lethal in mice due to abnormalities in the lung and the muscularis propria of the bladder and intestine. PLoS ONE. 2022;17:e0270820 pubmed publisher
  • flow cytometry; mouse; 1:100; loading ...; fig 8e
He Z, Zhang J, Huang Z, Du Q, Li N, Zhang Q, et al. Sumoylation of RORγt regulates TH17 differentiation and thymocyte development. Nat Commun. 2018;9:4870 pubmed publisher
  • flow cytometry; mouse; loading ...; fig ev2c
Er J, Koean R, Ding J. Loss of T-bet confers survival advantage to influenza-bacterial superinfection. EMBO J. 2019;38: pubmed publisher
  • flow cytometry; mouse; 1:300; loading ...; fig 1c
Zhu L, Xie X, Zhang L, Wang H, Jie Z, Zhou X, et al. TBK-binding protein 1 regulates IL-15-induced autophagy and NKT cell survival. Nat Commun. 2018;9:2812 pubmed publisher
  • flow cytometry; mouse; loading ...; fig s4a
Jones R, Cosway E, Willis C, White A, Jenkinson W, Fehling H, et al. Dynamic changes in intrathymic ILC populations during murine neonatal development. Eur J Immunol. 2018;48:1481-1491 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 5a
Cowan J, Baik S, McCarthy N, Parnell S, White A, Jenkinson W, et al. Aire controls the recirculation of murine Foxp3+ regulatory T-cells back to the thymus. Eur J Immunol. 2018;48:844-854 pubmed publisher
  • flow cytometry; mouse; 1:400; loading ...
Mao A, Ishizuka I, Kasal D, Mandal M, Bendelac A. A shared Runx1-bound Zbtb16 enhancer directs innate and innate-like lymphoid lineage development. Nat Commun. 2017;8:863 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 3e
Chae W, Park J, Henegariu O, Yilmaz S, Hao L, Bothwell A. Membrane-bound Dickkopf-1 in Foxp3+ regulatory T cells suppresses T-cell-mediated autoimmune colitis. Immunology. 2017;152:265-275 pubmed publisher
  • flow cytometry; mouse; fig 1d
Szabo P, Goswami A, Mazzuca D, Kim K, O Gorman D, Hess D, et al. Rapid and Rigorous IL-17A Production by a Distinct Subpopulation of Effector Memory T Lymphocytes Constitutes a Novel Mechanism of Toxic Shock Syndrome Immunopathology. J Immunol. 2017;198:2805-2818 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 2a
Wei Y, Lu C, Chen J, Cui G, Wang L, Yu T, et al. High salt diet stimulates gut Th17 response and exacerbates TNBS-induced colitis in mice. Oncotarget. 2017;8:70-82 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 5b
Yanagisawa H, Hashimoto M, Minagawa S, Takasaka N, Ma R, Moermans C, et al. Role of IL-17A in murine models of COPD airway disease. Am J Physiol Lung Cell Mol Physiol. 2017;312:L122-L130 pubmed publisher
  • flow cytometry; mouse; loading ...
Ramirez Carrozzi V, Sambandam A, Zhou M, Yan D, Kang J, Wu X, et al. Combined blockade of the IL-13 and IL-33 pathways leads to a greater inhibition of type 2 inflammation over inhibition of either pathway alone. J Allergy Clin Immunol. 2017;139:705-708.e6 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 3h
Drennan M, Govindarajan S, Verheugen E, Coquet J, Staal J, McGuire C, et al. NKT sublineage specification and survival requires the ubiquitin-modifying enzyme TNFAIP3/A20. J Exp Med. 2016;213:1973-81 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 3
Lebrero Fernández C, Bas Forsberg A. The ontogeny of Butyrophilin-like (Btnl) 1 and Btnl6 in murine small intestine. Sci Rep. 2016;6:31524 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 1g
Carow B, Gao Y, Coquet J, Reilly M, Rottenberg M. lck-Driven Cre Expression Alters T Cell Development in the Thymus and the Frequencies and Functions of Peripheral T Cell Subsets. J Immunol. 2016;197:2261-8 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 4c
Cheng H, Gaddis D, Wu R, McSkimming C, Haynes L, Taylor A, et al. Loss of ABCG1 influences regulatory T cell differentiation and atherosclerosis. J Clin Invest. 2016;126:3236-46 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 6A
Veinotte L, Gebremeskel S, Johnston B. CXCL16-positive dendritic cells enhance invariant natural killer T cell-dependent IFN? production and tumor control. Oncoimmunology. 2016;5:e1160979 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 4e
Barin J, Talor M, Schaub J, Diny N, Hou X, Hoyer M, et al. Collaborative Interferon-? and Interleukin-17 Signaling Protects the Oral Mucosa from Staphylococcus aureus. Am J Pathol. 2016;186:2337-52 pubmed publisher
  • flow cytometry; mouse; loading ...
Kang J, Park S, Jeong S, Han M, Lee C, Lee K, et al. Epigenetic regulation of Kcna3-encoding Kv1.3 potassium channel by cereblon contributes to regulation of CD4+ T-cell activation. Proc Natl Acad Sci U S A. 2016;113:8771-6 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 1b
Webb L, Ley S, Seddon B. TNF activation of NF-κB is essential for development of single-positive thymocytes. J Exp Med. 2016;213:1399-407 pubmed publisher
  • flow cytometry; mouse; loading ...; fig s1h
Ibiza S, García Cassani B, Ribeiro H, Carvalho T, Almeida L, Marques R, et al. Glial-cell-derived neuroregulators control type 3 innate lymphoid cells and gut defence. Nature. 2016;535:440-443 pubmed publisher
  • flow cytometry; mouse; loading ...; fig s1a
Sujino T, London M, Hoytema van Konijnenburg D, Rendon T, Buch T, Silva H, et al. Tissue adaptation of regulatory and intraepithelial CD4? T cells controls gut inflammation. Science. 2016;352:1581-6 pubmed publisher
  • flow cytometry; mouse; loading ...
Gabunia K, Ellison S, Kelemen S, Kako F, Cornwell W, Rogers T, et al. IL-19 Halts Progression of Atherosclerotic Plaque, Polarizes, and Increases Cholesterol Uptake and Efflux in Macrophages. Am J Pathol. 2016;186:1361-74 pubmed publisher
  • immunocytochemistry; mouse; loading ...
Malinova D, Fritzsche M, Nowosad C, Armer H, Munro P, Blundell M, et al. WASp-dependent actin cytoskeleton stability at the dendritic cell immunological synapse is required for extensive, functional T cell contacts. J Leukoc Biol. 2016;99:699-710 pubmed publisher
  • immunocytochemistry; mouse; fig 1
Lin W, Fan Z, Suo Y, Deng Y, Zhang M, Wang J, et al. The bullseye synapse formed between CD4+ T-cell and staphylococcal enterotoxin B-pulsed dendritic cell is a suppressive synapse in T-cell response. Immunol Cell Biol. 2015;93:99-110 pubmed publisher
  • flow cytometry; mouse
Walker C, Hautefort I, Dalton J, Overweg K, Egan C, Bongaerts R, et al. Intestinal intraepithelial lymphocyte-enterocyte crosstalk regulates production of bactericidal angiogenin 4 by Paneth cells upon microbial challenge. PLoS ONE. 2013;8:e84553 pubmed publisher
  • flow cytometry; mouse; tbl 2
Mandal M, Donnelly R, Elkabes S, Zhang P, Davini D, David B, et al. Maternal immune stimulation during pregnancy shapes the immunological phenotype of offspring. Brain Behav Immun. 2013;33:33-45 pubmed publisher
  • flow cytometry; mouse; fig 2
Merck E, Voyle R, MacDonald H. Ly49D engagement on T lymphocytes induces TCR-independent activation and CD8 effector functions that control tumor growth. J Immunol. 2009;182:183-92 pubmed
  • flow cytometry; mouse; fig 5
Kanwar N, Fayyazi A, Backofen B, Nitsche M, Dressel R, von Mollard G. Thymic alterations in mice deficient for the SNARE protein VAMP8/endobrevin. Cell Tissue Res. 2008;334:227-42 pubmed publisher
  • flow cytometry; mouse
Sprengers D, Sillé F, Derkow K, Besra G, Janssen H, Schott E, et al. Critical role for CD1d-restricted invariant NKT cells in stimulating intrahepatic CD8 T-cell responses to liver antigen. Gastroenterology. 2008;134:2132-43 pubmed publisher
  • flow cytometry; mouse; fig 1
Woolard M, Hensley L, Kawula T, Frelinger J. Respiratory Francisella tularensis live vaccine strain infection induces Th17 cells and prostaglandin E2, which inhibits generation of gamma interferon-positive T cells. Infect Immun. 2008;76:2651-9 pubmed publisher
  • flow cytometry; mouse
Jeannet G, Scheller M, Scarpellino L, Duboux S, Gardiol N, Back J, et al. Long-term, multilineage hematopoiesis occurs in the combined absence of beta-catenin and gamma-catenin. Blood. 2008;111:142-9 pubmed
  • flow cytometry; mouse
Fucs R, Jesus J, Souza Junior P, Franco L, Verícimo M, Bellio M, et al. Frequency of natural regulatory CD4+CD25+ T lymphocytes determines the outcome of tolerance across fully mismatched MHC barrier through linked recognition of self and allogeneic stimuli. J Immunol. 2006;176:2324-9 pubmed
  • other; mouse
Koneru M, Schaer D, Monu N, Ayala A, Frey A. Defective proximal TCR signaling inhibits CD8+ tumor-infiltrating lymphocyte lytic function. J Immunol. 2005;174:1830-40 pubmed
  • flow cytometry; mouse
Zhang T, He X, Tsang T, Harris D. Transgenic TCR expression: comparison of single chain with full-length receptor constructs for T-cell function. Cancer Gene Ther. 2004;11:487-96 pubmed
  • flow cytometry; mouse; fig 1
Germeraad W, Kawamoto H, Itoi M, Jiang Y, Amagai T, Katsura Y, et al. Development of thymic microenvironments in vitro is oxygen-dependent and requires permanent presence of T-cell progenitors. J Histochem Cytochem. 2003;51:1225-35 pubmed
  • flow cytometry; mouse
Reading P, Smith G. A kinetic analysis of immune mediators in the lungs of mice infected with vaccinia virus and comparison with intradermal infection. J Gen Virol. 2003;84:1973-83 pubmed
  • flow cytometry; mouse; fig 3
Flano E, Kim I, Moore J, Woodland D, Blackman M. Differential gamma-herpesvirus distribution in distinct anatomical locations and cell subsets during persistent infection in mice. J Immunol. 2003;170:3828-34 pubmed
  • flow cytometry; mouse
Ikawa T, Kawamoto H, Fujimoto S, Katsura Y. Commitment of common T/Natural killer (NK) progenitors to unipotent T and NK progenitors in the murine fetal thymus revealed by a single progenitor assay. J Exp Med. 1999;190:1617-26 pubmed
  • flow cytometry; mouse
Kretz Rommel A, Rubin R. Persistence of autoreactive T cell drive is required to elicit anti-chromatin antibodies in a murine model of drug-induced lupus. J Immunol. 1999;162:813-20 pubmed
  • flow cytometry; mouse
Pear W, Aster J, Scott M, Hasserjian R, Soffer B, Sklar J, et al. Exclusive development of T cell neoplasms in mice transplanted with bone marrow expressing activated Notch alleles. J Exp Med. 1996;183:2283-91 pubmed
  • flow cytometry; mouse
Ohteki T, MacDonald H. Major histocompatibility complex class I related molecules control the development of CD4+8- and CD4-8- subsets of natural killer 1.1+ T cell receptor-alpha/beta+ cells in the liver of mice. J Exp Med. 1994;180:699-704 pubmed
  • flow cytometry; mouse
Petrie H, Livak F, Burtrum D, Mazel S. T cell receptor gene recombination patterns and mechanisms: cell death, rescue, and T cell production. J Exp Med. 1995;182:121-7 pubmed
  • flow cytometry; mouse
Ohteki T, Iwamoto M, Izui S, MacDonald H. Reduced development of CD4-8-B220+ T cells but normal autoantibody production in lpr/lpr mice lacking major histocompatibility complex class I molecules. Eur J Immunol. 1995;25:37-41 pubmed
Bergmann B, Fei Y, Jirholt P, Hu Z, Bergquist M, Ali A, et al. Pre-treatment with IL2 gene therapy alleviates Staphylococcus aureus arthritis in mice. BMC Infect Dis. 2020;20:185 pubmed publisher
Andersen L, Gülich A, Alteneder M, Preglej T, Orola M, Dhele N, et al. The Transcription Factor MAZR/PATZ1 Regulates the Development of FOXP3+ Regulatory T Cells. Cell Rep. 2019;29:4447-4459.e6 pubmed publisher
Palanisamy N, Degen A, Morath A, Ballestin Ballestin J, Juraske C, Ozturk M, et al. Split intein-mediated selection of cells containing two plasmids using a single antibiotic. Nat Commun. 2019;10:4967 pubmed publisher
Niavarani S, Lawson C, Bakos O, Boudaud M, Batenchuk C, Rouleau S, et al. Lipid accumulation impairs natural killer cell cytotoxicity and tumor control in the postoperative period. BMC Cancer. 2019;19:823 pubmed publisher
Vacchio M, Ciucci T, Gao Y, Watanabe M, Balmaceno Criss M, McGinty M, et al. A Thpok-Directed Transcriptional Circuitry Promotes Bcl6 and Maf Expression to Orchestrate T Follicular Helper Differentiation. Immunity. 2019;51:465-478.e6 pubmed publisher
Qian L, Bajana S, Georgescu C, Peng V, Wang H, Adrianto I, et al. Suppression of ILC2 differentiation from committed T cell precursors by E protein transcription factors. J Exp Med. 2019;216:884-899 pubmed publisher
Graham K, Werner B, Moyer K, Patton A, Krois C, Yoo H, et al. DGAT1 inhibits retinol-dependent regulatory T cell formation and mediates autoimmune encephalomyelitis. Proc Natl Acad Sci U S A. 2019;116:3126-3135 pubmed publisher
Simonović N, Witalisz Siepracka A, Meissl K, Lassnig C, Reichart U, Kolbe T, et al. NK Cells Require Cell-Extrinsic and -Intrinsic TYK2 for Full Functionality in Tumor Surveillance and Antibacterial Immunity. J Immunol. 2019;202:1724-1734 pubmed publisher
Ronkina N, Schuster Gossler K, Hansmann F, Kunze Schumacher H, Sandrock I, Yakovleva T, et al. Germ Line Deletion Reveals a Nonessential Role of Atypical Mitogen-Activated Protein Kinase 6/Extracellular Signal-Regulated Kinase 3. Mol Cell Biol. 2019;39: pubmed publisher
Gubernatorova E, Gorshkova E, Namakanova O, Zvartsev R, Hidalgo J, Drutskaya M, et al. Non-redundant Functions of IL-6 Produced by Macrophages and Dendritic Cells in Allergic Airway Inflammation. Front Immunol. 2018;9:2718 pubmed publisher
Muscate F, Stetter N, Schramm C, Schulze zur Wiesch J, Bosurgi L, Jacobs T. HVEM and CD160: Regulators of Immunopathology During Malaria Blood-Stage. Front Immunol. 2018;9:2611 pubmed publisher
Zhang W, Li Q, Li D, Li J, Aki D, Liu Y. The E3 ligase VHL controls alveolar macrophage function via metabolic-epigenetic regulation. J Exp Med. 2018;215:3180-3193 pubmed publisher
Kunze Schumacher H, Winter S, Imelmann E, Krueger A. miRNA miR-21 Is Largely Dispensable for Intrathymic T-Cell Development. Front Immunol. 2018;9:2497 pubmed publisher
Shi H, Liu C, Tan H, Li Y, Nguyen T, Dhungana Y, et al. Hippo Kinases Mst1 and Mst2 Sense and Amplify IL-2R-STAT5 Signaling in Regulatory T Cells to Establish Stable Regulatory Activity. Immunity. 2018;49:899-914.e6 pubmed publisher
Oike T, Kanagawa H, Sato Y, Kobayashi T, Nakatsukasa H, Miyamoto K, et al. IL-6, IL-17 and Stat3 are required for auto-inflammatory syndrome development in mouse. Sci Rep. 2018;8:15783 pubmed publisher
Song M, Sandoval T, Chae C, Chopra S, Tan C, Rutkowski M, et al. IRE1α-XBP1 controls T cell function in ovarian cancer by regulating mitochondrial activity. Nature. 2018;562:423-428 pubmed publisher
Sequeira I, Neves J, Carrero D, Peng Q, Palasz N, Liakath Ali K, et al. Immunomodulatory role of Keratin 76 in oral and gastric cancer. Nat Commun. 2018;9:3437 pubmed publisher
Bohrer A, Tocheny C, Assmann M, Ganusov V, Mayer Barber K. Cutting Edge: IL-1R1 Mediates Host Resistance to Mycobacterium tuberculosis by Trans-Protection of Infected Cells. J Immunol. 2018;201:1645-1650 pubmed publisher
Xing S, Shao P, Li F, Zhao X, Seo W, Wheat J, et al. Tle corepressors are differentially partitioned to instruct CD8+ T cell lineage choice and identity. J Exp Med. 2018;215:2211-2226 pubmed publisher
Kobiyama K, Vassallo M, Mitzi J, Winkels H, Pei H, Kimura T, et al. A clinically applicable adjuvant for an atherosclerosis vaccine in mice. Eur J Immunol. 2018;48:1580-1587 pubmed publisher
Schabla N, Perry G, Palmer V, Swanson P. VprBP (DCAF1) Regulates RAG1 Expression Independently of Dicer by Mediating RAG1 Degradation. J Immunol. 2018;201:930-939 pubmed publisher
Kirkling M, Cytlak U, Lau C, Lewis K, Resteu A, Khodadadi Jamayran A, et al. Notch Signaling Facilitates In Vitro Generation of Cross-Presenting Classical Dendritic Cells. Cell Rep. 2018;23:3658-3672.e6 pubmed publisher
Webster B, Werneke S, Zafirova B, This S, Coléon S, Decembre E, et al. Plasmacytoid dendritic cells control dengue and Chikungunya virus infections via IRF7-regulated interferon responses. elife. 2018;7: pubmed publisher
Jogdand G, Sengupta S, Bhattacharya G, Singh S, Barik P, Devadas S. Inducible Costimulator Expressing T Cells Promote Parasitic Growth During Blood Stage Plasmodium berghei ANKA Infection. Front Immunol. 2018;9:1041 pubmed publisher
Hu M, Ethridge A, Lipstein R, Kumar S, Wang Y, Jabri B, et al. Epithelial IL-15 Is a Critical Regulator of γδ Intraepithelial Lymphocyte Motility within the Intestinal Mucosa. J Immunol. 2018;201:747-756 pubmed publisher
Que X, Hung M, Yeang C, Gonen A, Prohaska T, Sun X, et al. Oxidized phospholipids are proinflammatory and proatherogenic in hypercholesterolaemic mice. Nature. 2018;558:301-306 pubmed publisher
Du X, Wen J, Wang Y, Karmaus P, Khatamian A, Tan H, et al. Hippo/Mst signalling couples metabolic state and immune function of CD8α+ dendritic cells. Nature. 2018;558:141-145 pubmed publisher
Wilhelmson A, Lantero Rodriguez M, Stubelius A, Fogelstrand P, Johansson I, Buechler M, et al. Testosterone is an endogenous regulator of BAFF and splenic B cell number. Nat Commun. 2018;9:2067 pubmed publisher
Andargachew R, Martinez R, Kolawole E, Evavold B. CD4 T Cell Affinity Diversity Is Equally Maintained during Acute and Chronic Infection. J Immunol. 2018;201:19-30 pubmed publisher
Tanaka S, Pfleger C, Lai J, Roan F, Sun S, Ziegler S. KAP1 Regulates Regulatory T Cell Function and Proliferation in Both Foxp3-Dependent and -Independent Manners. Cell Rep. 2018;23:796-807 pubmed publisher
Youssef L, Rebbaa A, Pampou S, Weisberg S, Stockwell B, Hod E, et al. Increased erythrophagocytosis induces ferroptosis in red pulp macrophages in a mouse model of transfusion. Blood. 2018;: pubmed publisher
Zhou Y, Wang W, Zhao C, Wang Y, Wu H, Sun X, et al. Prostaglandin E2 Inhibits Group 2 Innate Lymphoid Cell Activation and Allergic Airway Inflammation Through E-Prostanoid 4-Cyclic Adenosine Monophosphate Signaling. Front Immunol. 2018;9:501 pubmed publisher
Gaddis D, Padgett L, Wu R, McSkimming C, Romines V, Taylor A, et al. Apolipoprotein AI prevents regulatory to follicular helper T cell switching during atherosclerosis. Nat Commun. 2018;9:1095 pubmed publisher
Langlais D, Cencic R, Moradin N, Kennedy J, Ayi K, Brown L, et al. Rocaglates as dual-targeting agents for experimental cerebral malaria. Proc Natl Acad Sci U S A. 2018;115:E2366-E2375 pubmed publisher
Liang W, Mao S, Sun S, Li M, Li Z, Yu R, et al. Core Fucosylation of the T Cell Receptor Is Required for T Cell Activation. Front Immunol. 2018;9:78 pubmed publisher
Cortes J, Ambesi Impiombato A, Couronné L, Quinn S, Kim C, da Silva Almeida A, et al. RHOA G17V Induces T Follicular Helper Cell Specification and Promotes Lymphomagenesis. Cancer Cell. 2018;33:259-273.e7 pubmed publisher
Tenno M, Kojo S, Lawir D, Hess I, Shiroguchi K, Ebihara T, et al. Cbfβ2 controls differentiation of and confers homing capacity to prethymic progenitors. J Exp Med. 2018;215:595-610 pubmed publisher
Kang E, Zhou G, Yousefi M, Cayrol R, Xia J, Gruenheid S. Loss of disease tolerance during Citrobacter rodentium infection is associated with impaired epithelial differentiation and hyperactivation of T cell responses. Sci Rep. 2018;8:847 pubmed publisher
Gaya M, Barral P, Burbage M, Aggarwal S, Montaner B, Warren Navia A, et al. Initiation of Antiviral B Cell Immunity Relies on Innate Signals from Spatially Positioned NKT Cells. Cell. 2018;172:517-533.e20 pubmed publisher
Muro R, Nitta T, Nakano K, Okamura T, Takayanagi H, Suzuki H. γδTCR recruits the Syk/PI3K axis to drive proinflammatory differentiation program. J Clin Invest. 2018;128:415-426 pubmed publisher
Kwak J, Laskowski J, Li H, McSharry M, Sippel T, Bullock B, et al. Complement Activation via a C3a Receptor Pathway Alters CD4+ T Lymphocytes and Mediates Lung Cancer Progression. Cancer Res. 2018;78:143-156 pubmed publisher
Kim Y, Kumar A, Chang C, Pyaram K. Reactive Oxygen Species Regulate the Inflammatory Function of NKT Cells through Promyelocytic Leukemia Zinc Finger. J Immunol. 2017;199:3478-3487 pubmed publisher
Kim S, Kim H, Yim Y, Ha S, Atarashi K, Tan T, et al. Maternal gut bacteria promote neurodevelopmental abnormalities in mouse offspring. Nature. 2017;549:528-532 pubmed publisher
Blanchfield L, Sabatino J, Lawrence L, Evavold B. NFM Cross-Reactivity to MOG Does Not Expand a Critical Threshold Level of High-Affinity T Cells Necessary for Onset of Demyelinating Disease. J Immunol. 2017;199:2680-2691 pubmed publisher
Yang K, Blanco D, Neale G, Vogel P, Avila J, Clish C, et al. Homeostatic control of metabolic and functional fitness of Treg cells by LKB1 signalling. Nature. 2017;548:602-606 pubmed publisher
Acuff N, Li X, Latha K, Nagy T, Watford W. Tpl2 Promotes Innate Cell Recruitment and Effector T Cell Differentiation To Limit Citrobacter rodentium Burden and Dissemination. Infect Immun. 2017;85: pubmed publisher
Carpenter A, Wohlfert E, Chopp L, Vacchio M, Nie J, Zhao Y, et al. Control of Regulatory T Cell Differentiation by the Transcription Factors Thpok and LRF. J Immunol. 2017;199:1716-1728 pubmed publisher
Roberts N, Adams B, McCarthy N, Tooze R, Parnell S, Anderson G, et al. Prdm1 Regulates Thymic Epithelial Function To Prevent Autoimmunity. J Immunol. 2017;199:1250-1260 pubmed publisher
Neal L, Qiu Y, Chung J, Xing E, Cho W, Malachowski A, et al. T Cell-Restricted Notch Signaling Contributes to Pulmonary Th1 and Th2 Immunity during Cryptococcus neoformans Infection. J Immunol. 2017;199:643-655 pubmed publisher
Pelly V, Coomes S, Kannan Y, Gialitakis M, Entwistle L, Perez Lloret J, et al. Interleukin 4 promotes the development of ex-Foxp3 Th2 cells during immunity to intestinal helminths. J Exp Med. 2017;214:1809-1826 pubmed publisher
Miao T, Symonds A, Singh R, Symonds J, Ogbe A, Omodho B, et al. Egr2 and 3 control adaptive immune responses by temporally uncoupling expansion from T cell differentiation. J Exp Med. 2017;214:1787-1808 pubmed publisher
Burton O, Tamayo J, Stranks A, Koleoglou K, Oettgen H. Allergen-specific IgG antibody signaling through FcγRIIb promotes food tolerance. J Allergy Clin Immunol. 2018;141:189-201.e3 pubmed publisher
Ratiu J, Racine J, Hasham M, Wang Q, Branca J, Chapman H, et al. Genetic and Small Molecule Disruption of the AID/RAD51 Axis Similarly Protects Nonobese Diabetic Mice from Type 1 Diabetes through Expansion of Regulatory B Lymphocytes. J Immunol. 2017;198:4255-4267 pubmed publisher
Meinicke H, Bremser A, Brack M, Schrenk K, Pircher H, Izcue A. KLRG1 impairs regulatory T-cell competitive fitness in the gut. Immunology. 2017;152:65-73 pubmed publisher
Meinicke H, Bremser A, Brack M, Akeus P, Pearson C, Bullers S, et al. Tumour-associated changes in intestinal epithelial cells cause local accumulation of KLRG1+ GATA3+ regulatory T cells in mice. Immunology. 2017;152:74-88 pubmed publisher
Lee H, Tian L, Bouladoux N, Davis J, Quinones M, Belkaid Y, et al. Dendritic cells expressing immunoreceptor CD300f are critical for controlling chronic gut inflammation. J Clin Invest. 2017;127:1905-1917 pubmed publisher
Eddens T, Elsegeiny W, Garcia Hernadez M, Castillo P, Trevejo Nuñez G, Serody K, et al. Pneumocystis-Driven Inducible Bronchus-Associated Lymphoid Tissue Formation Requires Th2 and Th17 Immunity. Cell Rep. 2017;18:3078-3090 pubmed publisher
Xu Z, Xing S, Shan Q, Gullicksrud J, Bair T, Du Y, et al. Cutting Edge: β-Catenin-Interacting Tcf1 Isoforms Are Essential for Thymocyte Survival but Dispensable for Thymic Maturation Transitions. J Immunol. 2017;198:3404-3409 pubmed publisher
Oh J, Oh D, Jung H, Lee H. A mechanism for the induction of type 2 immune responses by a protease allergen in the genital tract. Proc Natl Acad Sci U S A. 2017;114:E1188-E1195 pubmed publisher
Guan J, Yang S, Gonzalez F, Yin Y, Shastri N. Antigen Processing in the Endoplasmic Reticulum Is Monitored by Semi-Invariant αβ TCRs Specific for a Conserved Peptide-Qa-1b MHC Class Ib Ligand. J Immunol. 2017;198:2017-2027 pubmed publisher
Holt M, Punkosdy G, Glass D, Shevach E. TCR Signaling and CD28/CTLA-4 Signaling Cooperatively Modulate T Regulatory Cell Homeostasis. J Immunol. 2017;198:1503-1511 pubmed publisher
Kugler D, Flomerfelt F, Costa D, Laky K, Kamenyeva O, Mittelstadt P, et al. Systemic toxoplasma infection triggers a long-term defect in the generation and function of naive T lymphocytes. J Exp Med. 2016;213:3041-3056 pubmed
Escalante N, Lemire P, Cruz Tleugabulova M, Prescott D, Mortha A, Streutker C, et al. The common mouse protozoa Tritrichomonas muris alters mucosal T cell homeostasis and colitis susceptibility. J Exp Med. 2016;213:2841-2850 pubmed
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product information
Product Type :
Antibody
Product Name :
TCR beta Monoclonal Antibody (H57-597)
Catalog # :
MA1-70045
Quantity :
250 µg
Price :
US 365.00
Clonality :
Monoclonal
Purity :
Protein G
Host :
Armenian Hamster
Reactivity :
Mouse
Applications :
Flow Cytometry: 1 µg/1 million cells, Immunohistochemistry (Frozen): Assay-dependent, Immunoprecipitation: Assay-dependent, Western Blot: Assay-dependent
Species :
Mouse
Clone :
H57-597
Isotype :
IgG
Storage :
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Description :
The ability of T cell receptors (TCR) to discriminate foreign from self-peptides presented by major histocompatibility complex (MHC) class II molecules is essential for an effective adaptive immune response. TCR recognition of self-peptides has been linked to autoimmune disease. Mutant self-peptides have been associated with tumors. Engagement of TCRs by a family of bacterial toxins know as superantigens has been responsible for toxic shock syndrome. Autoantibodies to V beta segments of T cell receptors have been isolated from patients with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). The autoantibodies block TH1-mediated inflammatory autodestructive reactions and are believed to be a method by which the immune system compensates for disease (ref5). T Cell and TCR Diversity Most human T cells express the TCR alpha-beta and either CD4 or CD8 molecule (single positive, SP). A small number of T cells lack both CD4 and CD8 (double negative, DN). Increased percentages of alpha-beta DN T cells have been identified in some autoimmune and immunodeficiency disorders. Gamma-delta T cells are primarily found within the epithelium. They show less TCR diversity and recognize antigens differently than alpha-beta T cells. Subsets of gamma-delta T cells have shown antitumor and immunoregulatory activity.
Immunogen :
Affinity purified D0 -11.10 TCR.
Format :
Liquid
Applications w/Dilutions :
Flow Cytometry: 1 µg/1 million cells, Immunohistochemistry (Frozen): Assay-dependent, Immunoprecipitation: Assay-dependent, Western Blot: Assay-dependent
Aliases :
bTCR; FLJ22602; MGC117436; MGC22624; MGC23964; MGC71411; T cell receptor beta chain; t-cell antigen receptor; T-cell receptor; TCR beta; Tcra; Tcrb; TCRbeta; TCRD; Tib; TRA
more info or order :
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA