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company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
NR3C2 Monoclonal Antibody (H10E4C9F)
catalog :
MA1-620
quantity :
100 uL
price :
US 451.00
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
H10E4C9F
reactivity :
human, mouse, rat, chicken, domestic sheep, domestic rabbit
application :
western blot, immunohistochemistry, immunocytochemistry, flow cytometry, immunohistochemistry - paraffin section, immunohistochemistry knockout validation
more info or order :
Invitrogen product webpage
citations: 25
Published Application/Species/Sample/DilutionReference
  • immunohistochemistry knockout validation; mouse; 1:500; loading ...; fig s1c
Marchetta P, Eckert P, Lukowski R, Ruth P, Singer W, R xfc ttiger L, et al. Loss of central mineralocorticoid or glucocorticoid receptors impacts auditory nerve processing in the cochlea. iScience. 2022;25:103981 pubmed publisher
  • western blot; human; 1:1000
Matić G, Vojnović Milutinović D, Nestorov J, Elaković I, Manitašević Jovanović S, Elzaedi Y, et al. Mineralocorticoid receptor and heat shock protein expression levels in peripheral lymphocytes from war trauma-exposed men with and without PTSD. Psychiatry Res. 2014;215:379-85 pubmed publisher
  • western blot; human; 1:1000
Milutinović D, Macut D, Bozic I, Nestorov J, Damjanovic S, Matic G. Hypothalamic-pituitary-adrenocortical axis hypersensitivity and glucocorticoid receptor expression and function in women with polycystic ovary syndrome. Exp Clin Endocrinol Diabetes. 2011;119:636-43 pubmed publisher
  • immunohistochemistry; human; 1:25
Bafford R, Sui X, Park M, Miyahara T, Newfell B, Jaffe I, et al. Mineralocorticoid receptor expression in human venous smooth muscle cells: a potential role for aldosterone signaling in vein graft arterialization. Am J Physiol Heart Circ Physiol. 2011;301:H41-7 pubmed publisher
  • immunohistochemistry; rat; 1:100
  • western blot; rat; 1:1,000
Prager E, Brielmaier J, Bergstrom H, McGuire J, Johnson L. Localization of mineralocorticoid receptors at mammalian synapses. PLoS ONE. 2010;5:e14344 pubmed publisher
  • western blot; human
Mitts T, Bunda S, Wang Y, Hinek A. Aldosterone and mineralocorticoid receptor antagonists modulate elastin and collagen deposition in human skin. J Invest Dermatol. 2010;130:2396-406 pubmed publisher
  • western blot; rat; 1:1,000
Velickovic N, Djordjevic A, Drakulic D, Stanojevic I, Secerov B, Horvat A. Cranial irradiation modulates hypothalamic-pituitary-adrenal axis activity and corticosteroid receptor expression in the hippocampus of juvenile rat. Gen Physiol Biophys. 2009;28 Spec No:219-27 pubmed
  • western blot; rat
Gauer S, Hauser I, Obermüller N, Holzmann Y, Geiger H, Goppelt Struebe M. Synergistic induction of osteopontin by aldosterone and inflammatory cytokines in mesangial cells. J Cell Biochem. 2008;103:615-23 pubmed
  • immunohistochemistry; rat; 1:100
Ge R, Dong Q, Sottas C, Latif S, Morris D, Hardy M. Stimulation of testosterone production in rat Leydig cells by aldosterone is mineralocorticoid receptor mediated. Mol Cell Endocrinol. 2005;243:35-42 pubmed
  • immunohistochemistry; domestic sheep; 1:200
Keller Wood M, Wood C, Hua Y, Zhang D. Mineralocorticoid receptor expression in late-gestation ovine fetal lung. J Soc Gynecol Investig. 2005;12:84-91 pubmed
Hong J, Lim J, Carvalho F, Cho J, Vaidyanathan B, Yu S, et al. Long-Term Programming of CD8 T Cell Immunity by Perinatal Exposure to Glucocorticoids. Cell. 2020;180:847-861.e15 pubmed publisher
Nordström C, Danckwardt Lillieström N, Liu W, Rask Andersen H. "Reversed polarization" of Na/K-ATPase-a sign of inverted transport in the human endolymphatic sac: a super-resolution structured illumination microscopy (SR-SIM) study. Cell Tissue Res. 2020;379:445-457 pubmed publisher
Bordin L, Saccardi C, Donà G, Sabbadin C, Andrisani A, Ambrosini G, et al. Mineralocorticoid receptor is involved in the aldosterone pathway in human red blood cells. Am J Transl Res. 2016;8:314-28 pubmed
Fujii M, Inoki I, Saga M, Morikawa N, Arakawa K, Inaba S, et al. Aldosterone inhibits endothelial morphogenesis and angiogenesis through the downregulation of vascular endothelial growth factor receptor-2 expression subsequent to peroxisome proliferator-activated receptor gamma. J Steroid Biochem Mol Biol. 2012;129:145-52 pubmed publisher
Bossis I, Nishimura S, Muchow M, Porter T. Pituitary expression of type I and type II glucocorticoid receptors during chicken embryonic development and their involvement in growth hormone cell differentiation. Endocrinology. 2004;145:3523-31 pubmed
Li G, Wang S, Gelehrter T. Identification of glucocorticoid receptor domains involved in transrepression of transforming growth factor-beta action. J Biol Chem. 2003;278:41779-88 pubmed
Kingsley Kallesen M, Mukhopadhyay S, Wyszomierski S, Schanler S, Schutz G, Rosen J. The mineralocorticoid receptor may compensate for the loss of the glucocorticoid receptor at specific stages of mammary gland development. Mol Endocrinol. 2002;16:2008-18 pubmed
Freeman B, Felts S, Toft D, Yamamoto K. The p23 molecular chaperones act at a late step in intracellular receptor action to differentially affect ligand efficacies. Genes Dev. 2000;14:422-34 pubmed
Lombes M, Binart N, Delahaye F, Baulieu E, Rafestin Oblin M. Differential intracellular localization of human mineralocorticosteroid receptor on binding of agonists and antagonists. Biochem J. 1994;302 ( Pt 1):191-7 pubmed
Kenouch S, Lombes M, Delahaye F, Eugene E, Bonvalet J, Farman N. Human skin as target for aldosterone: coexpression of mineralocorticoid receptors and 11 beta-hydroxysteroid dehydrogenase. J Clin Endocrinol Metab. 1994;79:1334-41 pubmed
Lombes M, Alfaidy N, Eugene E, Lessana A, Farman N, Bonvalet J. Prerequisite for cardiac aldosterone action. Mineralocorticoid receptor and 11 beta-hydroxysteroid dehydrogenase in the human heart. Circulation. 1995;92:175-82 pubmed
Lombes M, Edelman I, Erlanger B. Internal image properties of a monoclonal auto-anti-idiotypic antibody and its binding to aldosterone receptors. J Biol Chem. 1989;264:2528-36 pubmed
Lombes M, Farman N, Oblin M, Baulieu E, Bonvalet J, Erlanger B, et al. Immunohistochemical localization of renal mineralocorticoid receptor by using an anti-idiotypic antibody that is an internal image of aldosterone. Proc Natl Acad Sci U S A. 1990;87:1086-8 pubmed
Lombes M, Oblin M, Gasc J, Baulieu E, Farman N, Bonvalet J. Immunohistochemical and biochemical evidence for a cardiovascular mineralocorticoid receptor. Circ Res. 1992;71:503-10 pubmed
Couette B, Lombes M, Baulieu E, Rafestin Oblin M. Aldosterone antagonists destabilize the mineralocorticosteroid receptor. Biochem J. 1992;282 ( Pt 3):697-702 pubmed
product information
Product Type :
Antibody
Product Name :
NR3C2 Monoclonal Antibody (H10E4C9F)
Catalog # :
MA1-620
Quantity :
100 uL
Price :
US 451.00
Clonality :
Monoclonal
Purity :
protein A
Host :
Mouse
Reactivity :
Chicken, Human, Rabbit, Rat
Applications :
Flow Cytometry: 1/20, Immunocytochemistry: Assay-dependent, Immunohistochemistry (Paraffin): 1/100, Inhibition Assays: Assay-dependent, Western Blot: 1:1,000
Species :
Chicken, Human, Rabbit, Rat
Clone :
H10E4C9F
Isotype :
IgG1
Storage :
-20 C, Avoid Freeze/Thaw Cycles
Description :
Steroid receptors are ligand-dependent, intracellular proteins that stimulate transcription of specific genes by binding to specific DNA sequences following activation by the appropriate hormone. Mineralocorticoids are a family of steroids, secreted by the adrenal cortex, necessary for the regulation of a number of metabolic processes including electrolyte regulation. These compounds exert their effect through their interaction with the mineralocorticoid receptor (MR) and that complex's subsequent association with DNA. Given the function of mineralocorticoids, it is not surprising to find that the kidney is a primary target organ for mineralocorticoids and that this organ has been shown to contain MR. The corresponding gene for the mineralocorticoid receptor is NR3C2.
Immunogen :
Aldosterone-3
Format :
Liquid
Applications w/Dilutions :
Flow Cytometry: 1/20, Immunocytochemistry: Assay-dependent, Immunohistochemistry (Paraffin): 1/100, Inhibition Assays: Assay-dependent, Western Blot: 1:1,000
Aliases :
aldosterone receptor; MCR; Mineralocorticoid receptor; Mineralocorticoid receptor (aldosterone receptor); mineralocorticoid receptor 1; mineralocorticoid receptor 2; mineralocorticoid receptor delta; Mlr; MR; NR3C2; NR3C2VIT; nuclear hormone receptor; nuclear receptor subfamily 3 group C member 2; nuclear receptor subfamily 3, group C, member 2; nuclear receptor subfamily 3, group C, member 2 variant 3
more info or order :
Invitrogen product webpage
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA