Gemin 2 Monoclonal Antibody (2E17) | Invitrogen MA1-5777 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Gemin 2 Monoclonal Antibody (2E17)

catalog :

MA1-5777

quantity :

100 uL

price :

US 592.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

2.00E+17

reactivity :

human, mouse, Xenopus laevis

application :

western blot, ELISA, immunocytochemistry, immunoprecipitation, flow cytometry

more info or order :

Invitrogen product webpage

citations: 1

Published Application/Species/Sample/Dilution	Reference
western blot; human; loading ...; fig 1a	Gribling Burrer A, Leichter M, Wurth L, Huttin A, Schlotter F, Troffer Charlier N, et al. SECIS-binding protein 2 interacts with the SMN complex and the methylosome for selenoprotein mRNP assembly and translation. Nucleic Acids Res. 2017;45:5399-5413 pubmed publisher

product information

Product Type :

Antibody

Product Name :

Gemin 2 Monoclonal Antibody (2E17)

Catalog # :

MA1-5777

Quantity :

100 uL

Price :

US 592.00

Clonality :

Monoclonal

Purity :

protein A

Host :

Mouse

Reactivity :

Human, Mouse, Xenopus laevis

Applications :

ELISA: Assay-dependent, Flow Cytometry: 1 ug for 10^6 cells, Immunocytochemistry: 5 ug/mL, Immunoprecipitation: Assay-dependent, Western Blot: Assay-dependent

Species :

Human, Mouse, Xenopus laevis

Clone :

2.00E+17

Isotype :

IgG1

Storage :

Store at 4 C short term. For long term storage, store at -20 C, avoiding freeze/thaw cycles.

Description :

SIP1 is one of the proteins found in the SMN complex, which consists of the survival of motor neuron (SMN) protein and several gemin proteins. The SMN complex is localized to a subnuclear compartment called gems (gemini of coiled bodies) and is required for assembly of spliceosomal snRNPs and for pre-mRNA splicing. SIP1 interacts directly with the SMN and it is required for formation of the SMN complex. A knockout mouse targeting the mouse homolog of this gene exhibited disrupted snRNP assembly and motor neuron degeneration. However, knockdown of the SIP1 mRNA in motor neurons showed normal motor axons while that of SMN mRNA did show abnormal motor axon outgrowth, indicating that SIP1 may have additional roles outside of the SMN complex.

Immunogen :

His-Gemin 2 fusion protein (amino acids 12 - 280, starting at 2nd methionine)

Format :

Liquid

Applications w/Dilutions :

ELISA: Assay-dependent, Flow Cytometry: 1 ug for 10^6 cells, Immunocytochemistry: 5 ug/mL, Immunoprecipitation: Assay-dependent, Western Blot: Assay-dependent

Aliases :

1700012N19Rik; Component of gems 2; gem (nuclear organelle) associated protein 2; gem nuclear organelle associated protein 2; gem nuclear organelle associated protein 2 S homeolog; gem-associated protein 2; GEMIN2; Gemin-2; gemin2.S; SIP 1; SIP1; SIP-1; SIP1 delta; sip1-delta; SMN interacting protein 1-delta; SMN interacting protein-1; SMN-interacting protein 1; survival of motor neuron protein interacting protein 1; Survival of motor neuron protein-interacting protein 1; survivor of motor neuron protein interacting protein 1; XELAEV_18042638mg

more info or order :

Invitrogen product webpage