This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
CENPE Monoclonal Antibody (1H12)
catalog :
MA1-5758
quantity :
100 uL
price :
US 814.00
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
1H12

The same clone is also sold as:
reactivity :
human
application :
western blot, immunocytochemistry, immunoprecipitation, flow cytometry
citations: 1
Reference
Jerabkova K, Liao Y, Kleiss C, Fournane S, Durik M, Agote Ar xe1 n A, et al. Deubiquitylase UCHL3 regulates bi-orientation and segregation of chromosomes during mitosis. FASEB J. 2020;34:12751-12767 pubmed publisher
product information
Product Type :
Antibody
Product Name :
CENPE Monoclonal Antibody (1H12)
Catalog # :
MA1-5758
Quantity :
100 uL
Price :
US 814.00
Clonality :
Monoclonal
Purity :
Ion-exchange chromatography
Host :
Mouse
Reactivity :
Human
Applications :
Flow Cytometry: 1.0 ug/1x10^6 cells, Immunocytochemistry: Assay-dependent, Immunoprecipitation: 3 ug/300 mg lysate, Western Blot: 0.5-1 ug/mL
Species :
Human
Clone :
1H12
Isotype :
IgG, kappa
Storage :
Store at 4 C short term. For long term storage, store at -20 C, avoiding freeze/thaw cycles.
Description :
14-3-3 sigma (stratifin, SFN, epithelial cell marker protein 1) is a member of a highly conserved family of 14-3-3 proteins that are present in all eukaryotic organisms. There are 7 known mammalian 14-3-3 isoforms epsilon, beta, zeta, gamma, theta, tau and they play important roles in many biological activities by binding to and altering the subcellular localization and/or stability of key molecules in various signaling cascades. 14-3-3 sigma was originally characterized as a human mammary epithelium marker and later rediscovered as an important molecule for cell cycle checkpoint regulation. Recently it has been reported that 14-3-3 sigma may serve as a prognosis marker predicting survival of pancreatic cancer patient treatment. 14-3-3 sigmais the only 14-3-3 isoform induced by the tumor suppressor protein p53, in response to g -irradiation and other DNA-damaging agents. 14-3-3 sigmais a p53-regulated inhibitor of G2/M progression and acts as a tumor suppressor gene that is inactivated by methylation of its 5' CpG islands in epithelial tumor cells. Two isoforms of human 14-3-3 sigma are produced by alternative splicing.
Immunogen :
Recombinant full length CENP-E protein (human) from SP2/0 cells
Format :
Liquid
Applications w/Dilutions :
Flow Cytometry: 1.0 ug/1x10^6 cells, Immunocytochemistry: Assay-dependent, Immunoprecipitation: 3 ug/300 mg lysate, Western Blot: 0.5-1 ug/mL
Aliases :
312kDa; AU019344; BC049989; C530022J18; Cenpe; CENP-E; centromere autoantigen E; Centromere autoantigen E (312kD); centromere protein E; centromere protein E, 312kDa; centromere-associated protein E; centromeric protein E; KIF10; kinesin 10; kinesin family member 10; kinesin superfamily protein 10; Kinesin-7; Kinesin-related protein CENPE; MCPH13; Motor domain of KIF10; N-7 kinesin; PPP1R61; protein phosphatase 1, regulatory subunit 61
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA