HAP1 Monoclonal Antibody (1B6) | Invitrogen MA1-46412 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

HAP1 Monoclonal Antibody (1B6)

catalog :

MA1-46412

quantity :

100 µL

price :

US 474

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

1B6

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section

more info or order :

Invitrogen product webpage

citations: 4

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry - paraffin section; human; 1:1000; fig 5e	Lumsden A, Young R, Pezos N, Keating D. Huntingtin-associated protein 1: Eutherian adaptation from a TRAK-like protein, conserved gene promoter elements, and localization in the human intestine. BMC Evol Biol. 2016;16:214 pubmed
immunoprecipitation; mouse immunohistochemistry; mouse western blot; mouse	Yang G, Yang M, Lim Y, Lu J, Wang T, Qi J, et al. Huntingtin associated protein 1 regulates trafficking of the amyloid precursor protein and modulates amyloid beta levels in neurons. J Neurochem. 2012;122:1010-22 pubmed publisher
	Cason S, Carman P, Van Duyne C, Goldsmith J, Dominguez R, Holzbaur E. Sequential dynein effectors regulate axonal autophagosome motility in a maturation-dependent pathway. J Cell Biol. 2021;220: pubmed publisher
	Gao R, Chakraborty A, Geater C, Pradhan S, Gordon K, Snowden J, et al. Mutant huntingtin impairs PNKP and ATXN3, disrupting DNA repair and transcription. elife. 2019;8: pubmed publisher

product information

Product Type :

Antibody

Product Name :

HAP1 Monoclonal Antibody (1B6)

Catalog # :

MA1-46412

Quantity :

100 µL

Price :

US 474

Clonality :

Monoclonal

Purity :

Protein G

Host :

Mouse

Reactivity :

Human, Mouse, Rat

Applications :

Flow Cytometry: 1 µg per million cells, Immunocytochemistry: Assay-Dependent, Immunohistochemistry (Frozen): 0.5-1.0 µg/mL, Immunohistochemistry (Paraffin): 0.5-1.0 µg/mL, Immunoprecipitation: 1:10-1:500, Western Blot: 0.5-1.0 µg/mL

Species :

Human, Mouse, Rat

Clone :

1B6

Isotype :

IgG1

Storage :

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Description :

Huntington's disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin. HAP1 was initially identified through a two-hybrid library screening; the binding of HAP1 to huntingtin correlated with the expansion of the polyglutamine tract. HAP1 also interacts with two cytoskeletal proteins (dynactin and pericentriolar autoantigen protein 1), suggesting that HAP1 may play a role in vesicular trafficking or organelle transport. HAP1 is also involved with the huntingtin-enhanced BDNF transport along the cellular microtubles. Attenuation of this process led to the loss of neurotrophic support and neuronal toxicity, which suggests that loss of this function might contribute to pathogenesis. Several alternatively spliced isoforms have been described for HAP1.

Immunogen :

Fusion protein from rat HAP1.

Format :

Liquid

Applications w/Dilutions :

Aliases :

Hap1; HAP-1; HAP-1 antibody; HAP1-A; HAP1-B; HAP2; hHLP1; HIP5; HLP; HLP1; huntingtin associated protein 1; huntingtin-associated protein 1; huntingtin-associated protein 2; neuroan 1

more info or order :

Invitrogen product webpage