Progesterone Receptor Monoclonal Antibody (alpha PR-22) | Invitrogen MA1-412 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Progesterone Receptor Monoclonal Antibody (alpha PR-22)

catalog :

MA1-412

quantity :

100 µg

price :

US 412.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

alpha PR-22

reactivity :

human, chicken

application :

western blot, immunocytochemistry, immunoprecipitation

more info or order :

Invitrogen product webpage

citations: 12

Published Application/Species/Sample/Dilution	Reference
western blot; human	Biazik J, Parker S, Murphy C, Thompson M. Uterine epithelial morphology and progesterone receptors in a mifepristone-treated viviparous lizard Pseudemoia entrecasteauxii (Squamata: Scincidae) during gestation. J Exp Zool B Mol Dev Evol. 2012;318:148-58 pubmed publisher
	El Mayet F, El Habbaa A, d Offay J, Jones C. Synergistic Activation of Bovine Herpesvirus 1 Productive Infection and Viral Regulatory Promoters by the Progesterone Receptor and Krüppel-Like Transcription Factor 15. J Virol. 2019;93: pubmed publisher
	Botos J, Xian W, Smith D, Smith C. Progesterone receptor deficient in chromatin binding has an altered cellular state. J Biol Chem. 2004;279:15231-9 pubmed
	Felts S, Owen B, Nguyen P, Trepel J, Donner D, Toft D. The hsp90-related protein TRAP1 is a mitochondrial protein with distinct functional properties. J Biol Chem. 2000;275:3305-12 pubmed
	Prapapanich V, Chen S, Smith D. Mutation of Hip's carboxy-terminal region inhibits a transitional stage of progesterone receptor assembly. Mol Cell Biol. 1998;18:944-52 pubmed
	Hu J, Toft D, Seeger C. Hepadnavirus assembly and reverse transcription require a multi-component chaperone complex which is incorporated into nucleocapsids. EMBO J. 1997;16:59-68 pubmed
	Prapapanich V, Chen S, Nair S, Rimerman R, Smith D. Molecular cloning of human p48, a transient component of progesterone receptor complexes and an Hsp70-binding protein. Mol Endocrinol. 1996;10:420-31 pubmed
	Johnson J, Beito T, Krco C, Toft D. Characterization of a novel 23-kilodalton protein of unactive progesterone receptor complexes. Mol Cell Biol. 1994;14:1956-63 pubmed
	Johnson J, Toft D. A novel chaperone complex for steroid receptors involving heat shock proteins, immunophilins, and p23. J Biol Chem. 1994;269:24989-93 pubmed
	Schneider W, Toft D, Sullivan W, Shyamala G. Interaction of murine progesterone receptors with specific monoclonal antibodies to the avian progesterone receptor. J Steroid Biochem. 1988;29:297-306 pubmed
	Bergeron C, Ferenczy A, Toft D, Shyamala G. Immunocytochemical study of progesterone receptors in hyperplastic and neoplastic endometrial tissues. Cancer Res. 1988;48:6132-6 pubmed
	Weigel N, Carter T, Schrader W, O Malley B. Chicken progesterone receptor is phosphorylated by a DNA-dependent protein kinase during in vitro transcription assays. Mol Endocrinol. 1992;6:8-14 pubmed

product information

Product Type :

Antibody

Product Name :

Progesterone Receptor Monoclonal Antibody (alpha PR-22)

Catalog # :

MA1-412

Quantity :

100 µg

Price :

US 412.00

Clonality :

Monoclonal

Purity :

purified

Host :

Mouse

Reactivity :

Chicken, Human, Reptile

Applications :

Gel Shift: Assay-dependent, Immunocytochemistry: 10 µg/mL, Immunoprecipitation: Assay-dependent, Western Blot: 1 µg/mL

Species :

Chicken, Human, Reptile

Clone :

alpha PR-22

Isotype :

IgG2b

Storage :

-20° C, Avoid Freeze/Thaw Cycles

Description :

The progesterone receptor (PR) is a member of the steroid family of nuclear receptors. The PR mediates the physiological effects of progesterone, which plays a central role in reproductive events associated with the establishment and maintenance of pregnancy. PR is found as a 94 kDa protein (Form A) or a 120 kDa protein (Form B) due to the use of alternative translation initiation sites. PR-B is the transcriptionally active form and is responsible for activating genes for the maintenance of the endometrium, maintenance of pregnancy, and inhibition of ovulation. PR-A is identical to PR-B except for a 165 amino acid deletion at the N-terminus. This deletion exposes a 140 amino acid inhibitory domain (ID) that acts as a repressor of steroid hormone transcriptional activity. In its inactive state, PgR forms a multiprotein complex which includes heat shock proteins and immunophins. Upon binding of progesterone hormone to its receptor, there is a conformational change that allows dimerization and binding of the receptor to progesterone response elements (PRE) sequences, resulting in activated transcription. A Null mutation in the PGR gene leads to pleiotrophic reproductive abnormalities.

Immunogen :

Progesterone receptor purified from chick oviduct cytosol.

Format :

Lyophilized

Applications w/Dilutions :

Gel Shift: Assay-dependent, Immunocytochemistry: 10 µg/mL, Immunoprecipitation: Assay-dependent, Western Blot: 1 µg/mL

Aliases :

9930019P03Rik; BB114106; ENSMUSG00000074510; LOW QUALITY PROTEIN: progesterone receptor; NR3C3; Nuclear receptor subfamily 3 group C member 3; p4 receptor; PGR; pot. alt. progesterone receptor; putative; PR; PR-A; PR-B; Progesterone receptor; progesterone receptor A; progesterone-receptor; putative form B; steroid hormone receptor; testicular progesterone receptor; unnamed protein product

more info or order :

Invitrogen product webpage