RAP1 Monoclonal Antibody (78B356.1) | Invitrogen MA1-41177 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

RAP1 Monoclonal Antibody (78B356.1)

catalog :

MA1-41177

quantity :

100 ug

price :

US 474.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

78B356.1

The same clone is also sold as:

Novus Biologicals: NBP2-80974, NB100-56526
OriGene: TA336387

reactivity :

human

application :

western blot

product information

Product Type :

Antibody

Product Name :

RAP1 Monoclonal Antibody (78B356.1)

Catalog # :

MA1-41177

Quantity :

100 ug

Price :

US 474.00

Clonality :

Monoclonal

Purity :

Protein G

Host :

Mouse

Reactivity :

Human

Applications :

Western Blot: 0.1-1 ug/mL

Species :

Human

Clone :

78B356.1

Isotype :

IgG1

Storage :

Store at 4 C short term. For long term storage, store at -20 C, avoiding freeze/thaw cycles.

Description :

Human Rap1 was the first identified ortholog of the yeast telomeric protein scRap1, which shares 3 conserved sequence motifs in common. HRap1 is located at telomeres and affects telomere length by being recruited to telomeres by TRF2 instead of directly binding to the telomere like scRap1. The hRap1 cDNA codes for a protein of 399 amino acids with approximate molecular weight of 47 kDa. The hRap1 protein does not interact with TRF1. TRF2 is a ubiquitously expressed protein that is implicated in the control of telomere length(1). TRF2, like TRF1 contains a Myb-related DNA binding motif. It binds to duplex TTAGGG repeats and is localized to all human telomeres in metaphase chromosomes. TRF2 is thought to protect chromosome ends by maintaining the correct structure at telomere termini. The use of mutant forms of TRF2 has implicated a role for TRF2 in the prevention of senescence in primary human cells. Recently, it has been shown that inhibition of TRF2 resulted in apoptosis in a subset of mammalian cell types.

Immunogen :

Synthetic peptide corresponding residues 212-235 of human Rap1.

Format :

Liquid

Applications w/Dilutions :

Western Blot: 0.1-1 ug/mL

Aliases :

dopamine receptor interacting protein 5; dopamine receptor-interacting protein 5; DRIP5; hRap1; MNCb-0448; MNCb-0628; PP8000; RAP1; RAP1 homolog; repressor/activator protein 1 homolog; tel; telomeric repeat binding factor 2, interacting protein; telomeric repeat-binding factor 2-interacting protein 1; TERF2 interacting protein; TERF21P; TERF2-interacting telomeric protein 1; TERF2IP; TRF2-interacting telomeric protein 1; TRF2-interacting telomeric protein Rap1; TRF2-interacting telomeric RAP1 protein