CD254 (RANK Ligand) Monoclonal Antibody (12A668) | Invitrogen MA1-41161 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

CD254 (RANK Ligand) Monoclonal Antibody (12A668)

catalog :

MA1-41161

quantity :

100 ug

price :

US 484.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

12A668

The same clone is also sold as:

Abcam: ab45039
Santa Cruz Biotechnology: sc-52950
OriGene: TA336377
Novus Biologicals: NB100-56512, NB100-56593
Rockland Immunochemicals: 200-301-I07

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry, immunocytochemistry, flow cytometry, immunohistochemistry - paraffin section

citations: 1

Reference
Sağlam E, Alinca S, Celik T, Hacisalihoglu U, Dogan M. Evaluation of the effect of topical and systemic ozone application in periodontitis: an experimental study in rats. J Appl Oral Sci. 2020;28:e20190140 pubmed publisher

product information

Product Type :

Antibody

Product Name :

CD254 (RANK Ligand) Monoclonal Antibody (12A668)

Catalog # :

MA1-41161

Quantity :

100 ug

Price :

US 484.00

Clonality :

Monoclonal

Purity :

Protein G

Host :

Mouse

Reactivity :

Human, Mouse, Rat

Applications :

ChIP Assay: 1:10-1:500, Flow Cytometry: Assay-Dependent, Immunocytochemistry: Assay-Dependent, Immunohistochemistry (Paraffin): 1-5 ug/mL, Western Blot: 1-2 ug/mL

Species :

Human, Mouse, Rat

Clone :

12A668

Isotype :

IgG1, kappa

Storage :

Store at 4 C short term. For long term storage, store at -20 C, avoiding freeze/thaw cycles.

Description :

This gene encodes a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation. This protein was shown to be a dentritic cell survival factor and is involved in the regulation of T cell-dependent immune response. T cell activation was reported to induce expression of this gene and lead to an increase of osteoclastogenesis and bone loss. This protein was shown to activate antiapoptotic kinase AKT/PKB through a signaling complex involving SRC kinase and tumor necrosis factor receptor-associated factor (TRAF) 6, which indicated this protein may have a role in the regulation of cell apoptosis. Targeted disruption of the related gene in mice led to severe osteopetrosis and a lack of osteoclasts. The deficient mice exhibited defects in early differentiation of T and B lymphocytes, and failed to form lobulo-alveolar mammary structures during pregnancy. Two alternatively spliced transcript variants have been found.

Immunogen :

Bacterially expressed fusion protein corresponding to residues 1-317 of mouse RANK-L.

Format :

Liquid

Applications w/Dilutions :

ChIP Assay: 1:10-1:500, Flow Cytometry: Assay-Dependent, Immunocytochemistry: Assay-Dependent, Immunohistochemistry (Paraffin): 1-5 ug/mL, Western Blot: 1-2 ug/mL

Aliases :

CD254; H-RANK-L; hRANKL2; Ly109l; M-Rank-L; ODF; OPG; OPG ligand; OPGL; OPTB2; Osteoclast differentiation factor; osteoprotegerin ligand; Rankl; rank-l; receptor activator of NF-kappaB ligand; receptor activator of nuclear factor kappa B ligand; receptor activator of nuclear factor kappa-B ligand; RP11-86N24.2; sOdf; srankl; TNF-related activation-induced cytokine; Tnfsf11; TNLG6B; Trance; tumor necrosis factor (ligand) superfamily member 11; tumor necrosis factor (ligand) superfamily, member 11; tumor necrosis factor ligand 6B; tumor necrosis factor ligand superfamily member 11; Tumor necrosis factor ligand superfamily member 11, membrane form; Tumor necrosis factor ligand superfamily member 11, soluble form; tumor necrosis factor superfamily member 11; tumor necrosis factor-related activation-induced cytokine