Bi-1 Monoclonal Antibody (20F430) | Invitrogen MA1-41108 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Bi-1 Monoclonal Antibody (20F430)

catalog :

MA1-41108

quantity :

100 µg

price :

US 403.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

20F430

reactivity :

human, mouse, rat

application :

immunohistochemistry, immunohistochemistry - paraffin section

more info or order :

Invitrogen product webpage

citations: 1

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry - paraffin section; rat; 1 ug/ml; fig 5	Galal A, El Bakly W, Al Haleem E, El Demerdash E. Selective A3 adenosine receptor agonist protects against doxorubicin-induced cardiotoxicity. Cancer Chemother Pharmacol. 2016;77:309-22 pubmed publisher

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product information

Product Type :

Antibody

Product Name :

Bi-1 Monoclonal Antibody (20F430)

Catalog # :

MA1-41108

Quantity :

100 µg

Price :

US 403.00

Clonality :

Monoclonal

Purity :

Protein G

Host :

Mouse

Reactivity :

Human, Mouse, Rat

Applications :

Immunohistochemistry (Paraffin): 5-10 µg/mL

Species :

Human, Mouse, Rat

Clone :

20F430

Isotype :

IgG2b, kappa

Storage :

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Description :

BI-1 (Bax Inhibitor 1) is in anti-apoptotic protein that has been linked to protection from apoptosis induced endoplasmic reticulum (ER) stress (reviewed in Bailley-Maitre et al, 2007). BI-1 contains several transmembrane domains, localizes to ER membranes, and has cytoprotective functions that are conserved in both animals and plants. BI-1 suppresses apoptosis induced by ectopic expression of the proapoptotic protein Bax as well as other types of stimuli. Cells from BI-1 knockout (KO) mice are hypersensitivite to apoptosis induced by ER stress-causing chemical agents (thapsigargin, tunicamycin, and brefeldin A) or by ischemia-reperfusion (IR) injury. Conversely, overexpression of BI-1 protects against apoptosis induced by ER stress and IR. The mechanism by which BI-1 protects cells from ER-stress induced apoptosis remains to be fully elucidated, itis thought to involve regulation of Ca2+ handling by the ER.

Immunogen :

Synthetic peptides corresponding to the N-terminal, internal, and C-terminal regions of human B1.

Format :

Liquid

Applications w/Dilutions :

Immunohistochemistry (Paraffin): 5-10 µg/mL

Aliases :

5031406P05Rik; Ab1-011; Ac1-149; Bax inhibitor 1; Bax inhibitor-1; BAXI1; Bi1; BI-1; Cc1-27; Tegt; testis enhanced gene transcript; testis-enhanced gene transcript protein; Tmbim6; transmembrane BAX inhibitor motif containing 6; transmembrane BAX inhibitor motif-containing protein 6

more info or order :

Invitrogen product webpage