Progesterone Receptor Monoclonal Antibody (Alpha PR6) | Invitrogen MA1-411 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Progesterone Receptor Monoclonal Antibody (Alpha PR6)

catalog :

MA1-411

quantity :

100 µg

price :

US 441.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

Alpha PR6

reactivity :

llama, guinea pig, human, mouse, rat, chicken, bovine, domestic sheep, domestic rabbit, rhesus macaque

application :

western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, immunohistochemistry - paraffin section, immunohistochemistry - frozen section

more info or order :

Invitrogen product webpage

citations: 45

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry - paraffin section; mouse; tbl 2	Luque R, Villa Osaba A, L LÃ³pez F, Pozo Salas A, SÃ¡nchez SÃ¡nchez R, Ortega Salas R, et al. Lack of cortistatin or somatostatin differentially influences DMBA-induced mammary gland tumorigenesis in mice in an obesity-dependent mode. Breast Cancer Res. 2016;18:29 pubmed publisher
immunohistochemistry - paraffin section; mouse; 1:500	Rajaram R, Buric D, Caikovski M, Ayyanan A, Rougemont J, Shan J, et al. Progesterone and Wnt4 control mammary stem cells via myoepithelial crosstalk. EMBO J. 2015;34:641-52 pubmed publisher
immunohistochemistry; human; 1:100	Bonnard A, Sahlin L, Hultcrantz M, Simonoska R. No direct nuclear effect of progesterone in the inner ear: other possible pathways. Acta Otolaryngol. 2013;133:1250-7 pubmed publisher
immunohistochemistry; domestic sheep; 1:40	Ruiz Gonzalez I, Sanchez M, Garcia Palencia P, Sanchez B, Garcia Fernandez R, Gonzalez Bulnes A, et al. Differences in uterine immunoexpression of PR, ER? and OTR when comparing prostaglandin- to progestagen-based protocols for ovine estrus synchronization. Anim Reprod Sci. 2012;133:93-100 pubmed publisher
immunohistochemistry; human; 1:100	Vladic Stjernholm Y, Vladic T, Blesson C, Ekman Ordeberg G, Sahlin L. Prostaglandin treatment is associated with a withdrawal of progesterone and androgen at the receptor level in the uterine cervix. Reprod Biol Endocrinol. 2009;7:116 pubmed publisher
immunohistochemistry; mouse; 1:200	McCarthy A, Lord C, Savage K, Grigoriadis A, Smith D, Weigelt B, et al. Conditional deletion of the Lkb1 gene in the mouse mammary gland induces tumour formation. J Pathol. 2009;219:306-16 pubmed publisher
immunohistochemistry; llama; 1:250	Bianchi C, Sahlin L, Meikle A, Masironi B, Cavilla M, Aba M. Endometrial population of oestrogen receptors alpha and beta and progesterone receptors A and B during the different phases of the follicular wave of llamas (Lama glama). Reprod Domest Anim. 2010;45:872-80 pubmed publisher
immunohistochemistry; domestic sheep; 1:50 western blot; domestic sheep; 1:20	Ortega H, Salvetti N, Padmanabhan V. Developmental programming: prenatal androgen excess disrupts ovarian steroid receptor balance. Reproduction. 2009;137:865-77 pubmed publisher
immunohistochemistry; rhesus macaque; 1:150	Ma L, Hofling M, Masironi B, von Schoultz B, Cline J, Sahlin L. Effects of tibolone and conventional HRT on the expression of estrogen and progesterone receptors in the breast. Maturitas. 2008;61:345-9 pubmed publisher
immunohistochemistry; human; 1:100	Johannesson U, Sahlin L, Masironi B, Hilliges M, Blomgren B, Rylander E, et al. Steroid receptor expression and morphology in provoked vestibulodynia. Am J Obstet Gynecol. 2008;198:311.e1-6 pubmed publisher
immunohistochemistry; human; 1:100	Zang H, Sahlin L, Masironi B, Hirschberg A. Effects of testosterone and estrogen treatment on the distribution of sex hormone receptors in the endometrium of postmenopausal women. Menopause. 2008;15:233-9 pubmed
immunohistochemistry; human; 1:100	Söderberg M, Johansson B, Masironi B, Bystrom B, Falconer C, Sahlin L, et al. Pelvic floor sex steroid hormone receptors, distribution and expression in pre- and postmenopausal stress urinary incontinent women. Acta Obstet Gynecol Scand. 2007;86:1377-84 pubmed
immunohistochemistry; human	Johannesson U, Sahlin L, Masironi B, Rylander E, Bohm Starke N. Steroid receptor expression in the vulvar vestibular mucosa--effects of oral contraceptives and menstrual cycle. Contraception. 2007;76:319-25 pubmed
immunohistochemistry; mouse; 1:200	McCarthy A, Savage K, Gabriel A, Naceur C, Reis Filho J, Ashworth A. A mouse model of basal-like breast carcinoma with metaplastic elements. J Pathol. 2007;211:389-98 pubmed
immunocytochemistry; chicken; 20 ug/ml	Giles J, Olson L, Johnson P. Characterization of ovarian surface epithelial cells from the hen: a unique model for ovarian cancer. Exp Biol Med (Maywood). 2006;231:1718-25 pubmed
immunohistochemistry; rat; 1:100	Sahlin L, Masironi B, Akerberg S, Eriksson H. Tissue- and hormone-dependent progesterone receptor distribution in the rat uterus. Reprod Biol Endocrinol. 2006;4:47 pubmed
immunohistochemistry; domestic sheep; 0.25 ug/ml	Satterfield M, Bazer F, Spencer T. Progesterone regulation of preimplantation conceptus growth and galectin 15 (LGALS15) in the ovine uterus. Biol Reprod. 2006;75:289-96 pubmed
immunohistochemistry; domestic sheep; 1:50	Juengel J, Heath D, Quirke L, McNatty K. Oestrogen receptor alpha and beta, androgen receptor and progesterone receptor mRNA and protein localisation within the developing ovary and in small growing follicles of sheep. Reproduction. 2006;131:81-92 pubmed
	Holah N. The Clinical Value of VDR and CTLA 4 in Evaluating the Prognosis of Invasive Duct Carcinoma of Egyptian Patients and their Benefit as a Target Therapy. Asian Pac J Cancer Prev. 2021;22:1183-1194 pubmed publisher
	Dischinger P, Tovar E, Essenburg C, Madaj Z, Gardner E, Callaghan M, et al. NF1 deficiency correlates with estrogen receptor signaling and diminished survival in breast cancer. NPJ Breast Cancer. 2018;4:29 pubmed publisher
	Magklara A, Smith C. A composite intronic element directs dynamic binding of the progesterone receptor and GATA-2. Mol Endocrinol. 2009;23:61-73 pubmed publisher
	Mote P, Arnett Mansfield R, Gava N, deFazio A, Mulac Jericevic B, Conneely O, et al. Overlapping and distinct expression of progesterone receptors A and B in mouse uterus and mammary gland during the estrous cycle. Endocrinology. 2006;147:5503-12 pubmed
	Yang Z, Wolf I, Chen H, Periyasamy S, Chen Z, Yong W, et al. FK506-binding protein 52 is essential to uterine reproductive physiology controlled by the progesterone receptor A isoform. Mol Endocrinol. 2006;20:2682-94 pubmed
	Botos J, Xian W, Smith D, Smith C. Progesterone receptor deficient in chromatin binding has an altered cellular state. J Biol Chem. 2004;279:15231-9 pubmed
	Stavreus Evers A, Hovatta O, Eriksson H, Landgren B. Development and characterization of an endometrial tissue culture system. Reprod Biomed Online. 2003;7:243-9 pubmed
	Isaksson E, Wang H, Sahlin L, von Schoultz B, Cline J, von Schoultz E. Effects of long-term HRT and tamoxifen on the expression of progesterone receptors A and B in breast tissue from surgically postmenopausal cynomolgus macaques. Breast Cancer Res Treat. 2003;79:233-9 pubmed
	Farnell Y, Ing N. Myometrial effects of selective estrogen receptor modulators on estradiol-responsive gene expression are gene and cell-specific. J Steroid Biochem Mol Biol. 2003;84:527-36 pubmed
	Farnell Y, Ing N. Endometrial effects of selective estrogen receptor modulators (SERMs) on estradiol-responsive gene expression are gene and cell-specific. J Steroid Biochem Mol Biol. 2003;84:513-26 pubmed
	Wang H, Isaksson E, von Schoultz B, Cline J, Sahlin L. Effect of long-term treatment with steroid hormones or tamoxifen on the progesterone receptor and androgen receptor in the endometrium of ovariectomized cynomolgus macaques. Reprod Biol Endocrinol. 2003;1:7 pubmed
	Gray C, Stewart M, Johnson G, Spencer T. Postpartum uterine involution in sheep: histoarchitecture and changes in endometrial gene expression. Reproduction. 2003;125:185-98 pubmed
	Wu X, Wang H, Englund K, Blanck A, Lindblom B, Sahlin L. Expression of progesterone receptors A and B and insulin-like growth factor-I in human myometrium and fibroids after treatment with a gonadotropin-releasing hormone analogue. Fertil Steril. 2002;78:985-93 pubmed
	Stavreus Evers A, Nikas G, Sahlin L, Eriksson H, Landgren B. Formation of pinopodes in human endometrium is associated with the concentrations of progesterone and progesterone receptors. Fertil Steril. 2001;76:782-91 pubmed
	Taylor K, Gray C, Joyce M, Stewart M, Bazer F, Spencer T. Neonatal ovine uterine development involves alterations in expression of receptors for estrogen, progesterone, and prolactin. Biol Reprod. 2000;63:1192-204 pubmed
	Johnson G, Spencer T, Burghardt R, Taylor K, Gray C, Bazer F. Progesterone modulation of osteopontin gene expression in the ovine uterus. Biol Reprod. 2000;62:1315-21 pubmed
	Johnson G, Spencer T, Burghardt R, Joyce M, Bazer F. Interferon-tau and progesterone regulate ubiquitin cross-reactive protein expression in the ovine uterus. Biol Reprod. 2000;62:622-7 pubmed
	Allison Gray C, Bartol F, Taylor K, Wiley A, Ramsey W, Ott T, et al. Ovine uterine gland knock-out model: effects of gland ablation on the estrous cycle. Biol Reprod. 2000;62:448-56 pubmed
	Spencer T, Gray A, Johnson G, Taylor K, Gertler A, Gootwine E, et al. Effects of recombinant ovine interferon tau, placental lactogen, and growth hormone on the ovine uterus. Biol Reprod. 1999;61:1409-18 pubmed
	Ing N, Tornesi M. Estradiol up-regulates estrogen receptor and progesterone receptor gene expression in specific ovine uterine cells. Biol Reprod. 1997;56:1205-15 pubmed
	Estes P, Suba E, Lawler Heavner J, Elashry Stowers D, Wei L, Toft D, et al. Immunologic analysis of human breast cancer progesterone receptors. 1. Immunoaffinity purification of transformed receptors and production of monoclonal antibodies. Biochemistry. 1987;26:6250-62 pubmed
	Schneider W, Toft D, Sullivan W, Shyamala G. Interaction of murine progesterone receptors with specific monoclonal antibodies to the avian progesterone receptor. J Steroid Biochem. 1988;29:297-306 pubmed
	Bergeron C, Ferenczy A, Toft D, Schneider W, Shyamala G. Immunocytochemical study of progesterone receptors in the human endometrium during the menstrual cycle. Lab Invest. 1988;59:862-9 pubmed
	Bergeron C, Ferenczy A, Toft D, Shyamala G. Immunocytochemical study of progesterone receptors in hyperplastic and neoplastic endometrial tissues. Cancer Res. 1988;48:6132-6 pubmed
	Pekki A, Joensuu T, Vidqvist K, Toft D, Tuohimaa P. Progesterone receptor concentration differences in the chick oviduct cells and apparent down-regulation by ligand. A semiquantitative immunohistochemical study. J Steroid Biochem. 1989;34:351-4 pubmed
	Joensuu T, Ylikomi T, Toft D, Keinanen R, Kulomaa M, Tuohimaa P. Progesterone-induced avidin as a marker of cytodifferentiation in the oviduct: comparison to ovalbumin. Endocrinology. 1990;126:1143-55 pubmed
	Yoshimura Y, Bahr J. Localization of progesterone receptors in pre- and postovulatory follicles of the domestic hen. Endocrinology. 1991;128:323-30 pubmed

product information

Product Type :

Antibody

Product Name :

Progesterone Receptor Monoclonal Antibody (Alpha PR6)

Catalog # :

MA1-411

Quantity :

100 µg

Price :

US 441.00

Clonality :

Monoclonal

Purity :

protein A

Host :

Mouse

Reactivity :

Bovine, Chicken, Guinea Pig, Human, Mouse, Ovine, Rabbit, Rat

Applications :

Immunocytochemistry: Assay-dependent, Immunohistochemistry (Frozen): 20 µg/mL, Immunohistochemistry (Paraffin): 5 µg/mL, Immunoprecipitation: Assay-dependent, Western Blot: 1 µg/mL

Species :

Bovine, Chicken, Guinea Pig, Human, Mouse, Ovine, Rabbit, Rat

Clone :

Alpha PR6

Isotype :

IgG2a

Storage :

-20° C, Avoid Freeze/Thaw Cycles

Description :

The progesterone receptor (PR) is a member of the steroid family of nuclear receptors. The PR mediates the physiological effects of progesterone, which plays a central role in reproductive events associated with the establishment and maintenance of pregnancy. PR is found as a 94 kDa protein (Form A) or a 120 kDa protein (Form B) due to the use of alternative translation initiation sites. PR-B is the transcriptionally active form and is responsible for activating genes for the maintenance of the endometrium, maintenance of pregnancy, and inhibition of ovulation. PR-A is identical to PR-B except for a 165 amino acid deletion at the N-terminus. This deletion exposes a 140 amino acid inhibitory domain (ID) that acts as a repressor of steroid hormone transcriptional activity. In its inactive state, PgR forms a multiprotein complex which includes heat shock proteins and immunophins. Upon binding of progesterone hormone to its receptor, there is a conformational change that allows dimerization and binding of the receptor to progesterone response elements (PRE) sequences, resulting in activated transcription. A Null mutation in the PGR gene leads to pleiotrophic reproductive abnormalities.

Immunogen :

Progesterone receptor purified from chick oviduct cytosol.

Format :

Lyophilized

Applications w/Dilutions :

Immunocytochemistry: Assay-dependent, Immunohistochemistry (Frozen): 20 µg/mL, Immunohistochemistry (Paraffin): 5 µg/mL, Immunoprecipitation: Assay-dependent, Western Blot: 1 µg/mL

Aliases :

9930019P03Rik; BB114106; ENSMUSG00000074510; LOW QUALITY PROTEIN: progesterone receptor; NR3C3; Nuclear receptor subfamily 3 group C member 3; p4 receptor; PGR; pot. alt. progesterone receptor; putative; PR; PR-A; PR-B; Progesterone receptor; progesterone receptor A; progesterone-receptor; putative form B; steroid hormone receptor; testicular progesterone receptor; unnamed protein product

more info or order :

Invitrogen product webpage