Anthrax Lethal Factor Monoclonal Antibody (5F502.2) | Invitrogen MA1-41075 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Anthrax Lethal Factor Monoclonal Antibody (5F502.2)

catalog :

MA1-41075

quantity :

100 ug

price :

US 474.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

5F502.2

reactivity :

anthrax bacterium

application :

western blot

product information

Product Type :

Antibody

Product Name :

Anthrax Lethal Factor Monoclonal Antibody (5F502.2)

Catalog # :

MA1-41075

Quantity :

100 ug

Price :

US 474.00

Clonality :

Monoclonal

Purity :

Protein G

Host :

Mouse

Reactivity :

Bacteria

Applications :

Western Blot: 0.1-1 ug/mL

Species :

Bacteria

Clone :

5F502.2

Isotype :

IgG1, kappa

Storage :

Store at 4 C short term. For long term storage, store at -20 C, avoiding freeze/thaw cycles.

Description :

Anthrax infection is initiated by the inhalation, ingestion, or cutaneous contact with Bacillus anthracis endospores. B. anthracis produces three polypeptides that comprise the anthrax toxin: protective antigen (PA), lethal factor (LF), and edema factor (EF). PA binds to two related proteins on the cell surface; these are termed tumor epithelial marker 8 (TEM8)/anthrax toxin receptor (ATR) and capillary morphogenesis protein 2 (CMG2), although it is still unclear which is physiologically relevant. Following PA binding to its receptor, PA is cleaved into two fragments by a furin-like protease. The bound fragment binds both LF and EF; the resulting complex is then endocytosed which allows the translocation of LF and EF into the cytoplasm. LF is the primary toxin of anthrax and functions as a highly specific protease that cleaves members of the mitogen-activated protein kinase kinase (MAPKK) family near their amino terminus, interfering with MAPK signaling and inducing apoptosis.

Immunogen :

Synthetic peptide corresponding to residues 779-792 of the anthrax LF protein.

Format :

Liquid

Applications w/Dilutions :

Western Blot: 0.1-1 ug/mL

Aliases :

Anthrax LF