Progesterone Receptor Monoclonal Antibody (PR-AT 4.14) | Invitrogen MA1-410 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Progesterone Receptor Monoclonal Antibody (PR-AT 4.14)

catalog :

MA1-410

quantity :

100 ug

price :

US 491.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

PR-AT 4.14

reactivity :

human, mouse, rat, bovine, domestic rabbit

application :

western blot, immunohistochemistry, immunoprecipitation, immunohistochemistry - paraffin section, immunohistochemistry - frozen section

citations: 61

Reference
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Stegemann L, Neufeld P, Hecking I, Vorgerd M, Matschke V, Stahlke S, et al. Progesterone: A Neuroprotective Steroid of the Intestine. Cells. 2023;12: pubmed publisher
Hosotani M, Akita M, Ueda H, Watanabe T. The histopathological features of the surgical endometriosis model using systemic autoimmune disease-prone mice. J Vet Med Sci. 2023;85:1-8 pubmed publisher
Hu M, Zhang Y, Lu Y, Han J, Guo T, Cui P, et al. Regulatory mechanisms of HMGB1 and its receptors in polycystic ovary syndrome-driven gravid uterine inflammation. FEBS J. 2023;290:1874-1906 pubmed publisher
Abdelnaby E, Yasin N, Abouelela Y, Rashad E, Daghash S, El Sherbiny H. Ovarian, uterine, and luteal vascular perfusions during follicular and luteal phases in the adult cyclic female rabbits with special orientation to their histological detection of hormone receptor. BMC Vet Res. 2022;18:301 pubmed publisher
Kotlarczyk A, Grzyb M, Korzekwa A. Regulation of uterine function during estrous cycle, anestrus phase and pregnancy by steroids in red deer (Cervus elaphus L.). Sci Rep. 2021;11:20109 pubmed publisher
Ji R, Li Y, He C, Zhu X, He A, Lu Y. Detection and analysis of multiple biomarkers in ovarian cancer: clinical significance in diagnosis, treatment, and prognosis evaluation. Gland Surg. 2020;9:2175-2186 pubmed publisher
Elsayed D, Abdelrazek H, Eltamany D, Ebaid H, El Nahla A. Effect of soy isoflavones on implantation losses in Wistar rat: implication of progesterone receptors, vascular endothelial growth factor and estradiol receptors alpha. Iran J Vet Res. 2020;21:46-51 pubmed
Thakkar A, Wang B, Picon Ruiz M, Buchwald P, Ince T. Vitamin D and androgen receptor-targeted therapy for triple-negative breast cancer. Breast Cancer Res Treat. 2016;157:77-90 pubmed publisher
Gevaert T, Rietjens R, Voets T, Everaerts W, De Ridder D. Topographies and isoforms of the progesterone receptor in female human, rat and mouse bladder. Cell Tissue Res. 2016;364:385-94 pubmed publisher
Welsh T, Hirst J, Palliser H, Zakar T. Progesterone receptor expression declines in the guinea pig uterus during functional progesterone withdrawal and in response to prostaglandins. PLoS ONE. 2014;9:e105253 pubmed publisher
Bonnard A, Sahlin L, Hultcrantz M, Simonoska R. No direct nuclear effect of progesterone in the inner ear: other possible pathways. Acta Otolaryngol. 2013;133:1250-7 pubmed publisher
Tahir M, Reynaud K, Mawa G, Thoumire S, Chastant Maillard S, Saint Dizier M. Immunolocalization of progesterone receptors in the canine oviduct around ovulation. Reprod Domest Anim. 2012;47 Suppl 6:35-9 pubmed publisher
Saint Dizier M, Sandra O, Ployart S, Chebrout M, Constant F. Expression of nuclear progesterone receptor and progesterone receptor membrane components 1 and 2 in the oviduct of cyclic and pregnant cows during the post-ovulation period. Reprod Biol Endocrinol. 2012;10:76 pubmed
Clark J, Alves S, Gundlah C, Rocha B, Birzin E, Cai S, et al. Selective estrogen receptor-beta (SERM-beta) compounds modulate raphe nuclei tryptophan hydroxylase-1 (TPH-1) mRNA expression and cause antidepressant-like effects in the forced swim test. Neuropharmacology. 2012;63:1051-63 pubmed publisher
Palliser H, Yates D, Hirst J. Progesterone receptor isoform expression in response to in utero growth restriction in the fetal guinea pig brain. Neuroendocrinology. 2012;96:60-7 pubmed publisher
Heijmans J, Muncan V, Jacobs R, de Jonge Muller E, Graven L, Biemond I, et al. Intestinal tumorigenesis is not affected by progesterone signaling in rodent models. PLoS ONE. 2011;6:e22620 pubmed publisher
Konno T, Graham A, Rempel L, Ho Chen J, Alam S, Bu P, et al. Subfertility linked to combined luteal insufficiency and uterine progesterone resistance. Endocrinology. 2010;151:4537-50 pubmed publisher
Palliser H, Zakar T, Symonds I, Hirst J. Progesterone receptor isoform expression in the guinea pig myometrium from normal and growth restricted pregnancies. Reprod Sci. 2010;17:776-82 pubmed publisher
Furuta M, Fukushima A, Chiba S, Sano A, Akema T, Kimura F, et al. Progesterone receptor immunoreactivity in the brains of ovariectomized aged rats. Neuroreport. 2010;21:777-81 pubmed publisher
Barbosa Vargas E, Pfaus J, Woodside B. Sexual behavior in lactating rats: role of estrogen-induced progesterone receptors. Horm Behav. 2009;56:246-53 pubmed publisher
Vitazka M, Cárdenas H, Cruz Y, Fadem B, Norfolk J, Harder J. Progesterone receptor in the forebrain of female gray short-tailed opossums: effects of exposure to male stimuli. Horm Behav. 2009;55:190-6 pubmed publisher
Mote P, Arnett Mansfield R, Gava N, deFazio A, Mulac Jericevic B, Conneely O, et al. Overlapping and distinct expression of progesterone receptors A and B in mouse uterus and mammary gland during the estrous cycle. Endocrinology. 2006;147:5503-12 pubmed
Sahlin L, Masironi B, Akerberg S, Eriksson H. Tissue- and hormone-dependent progesterone receptor distribution in the rat uterus. Reprod Biol Endocrinol. 2006;4:47 pubmed
Garcia Palencia P, Sanchez M, Nieto A, Vilar M, Gonzalez M, Veiga Lopez A, et al. Sex steroid receptor expression in the oviduct and uterus of sheep with estrus synchronized with progestagen or prostaglandin analogues. Anim Reprod Sci. 2007;97:25-35 pubmed
Markey C, Wadia P, Rubin B, Sonnenschein C, Soto A. Long-term effects of fetal exposure to low doses of the xenoestrogen bisphenol-A in the female mouse genital tract. Biol Reprod. 2005;72:1344-51 pubmed
Hartel A, Didier A, Ulbrich S, Wierer M, Meyer H. Characterisation of steroid receptor expression in the human prostate carcinoma cell line 22RV1 and quantification of androgen effects on mRNA regulation of prostate-specific genes. J Steroid Biochem Mol Biol. 2004;92:187-97 pubmed
Mirkin S, Nikas G, Hsiu J, Diaz J, Oehninger S. Gene expression profiles and structural/functional features of the peri-implantation endometrium in natural and gonadotropin-stimulated cycles. J Clin Endocrinol Metab. 2004;89:5742-52 pubmed
Shah C, Modi D, Sachdeva G, Gadkar S, Puri C. Coexistence of intracellular and membrane-bound progesterone receptors in human testis. J Clin Endocrinol Metab. 2005;90:474-83 pubmed
Quirk S, Cowan R, Harman R. Progesterone receptor and the cell cycle modulate apoptosis in granulosa cells. Endocrinology. 2004;145:5033-43 pubmed
Abizaid A, Service G, Woodside B. Food restriction during lactation results in prolonged hyposensitivity to the positive-feedback effects of oestradiol. J Neuroendocrinol. 2003;15:1037-45 pubmed
Rodriguez H, Kass L, Varayoud J, Ramos J, Ortega H, Durando M, et al. Collagen remodelling in the guinea-pig uterine cervix at term is associated with a decrease in progesterone receptor expression. Mol Hum Reprod. 2003;9:807-13 pubmed
Stavreus Evers A, Hovatta O, Eriksson H, Landgren B. Development and characterization of an endometrial tissue culture system. Reprod Biomed Online. 2003;7:243-9 pubmed
Caba M, Rovirosa M, Beyer C, González Mariscal G. Immunocytochemical detection of progesterone receptor in the female rabbit forebrain: distribution and regulation by oestradiol and progesterone. J Neuroendocrinol. 2003;15:855-64 pubmed
Bethea C, Lu N, Reddy A, Shlaes T, Streicher J, Whittemore S. Characterization of reproductive steroid receptors and response to estrogen in a rat serotonergic cell line. J Neurosci Methods. 2003;127:31-41 pubmed
Sommer A, Hoffmann J, Lichtner R, Schneider M, Parczyk K. Studies on the development of resistance to the pure antiestrogen Faslodex in three human breast cancer cell lines. J Steroid Biochem Mol Biol. 2003;85:33-47 pubmed
Patel F, Funder J, Challis J. Mechanism of cortisol/progesterone antagonism in the regulation of 15-hydroxyprostaglandin dehydrogenase activity and messenger ribonucleic acid levels in human chorion and placental trophoblast cells at term. J Clin Endocrinol Metab. 2003;88:2922-33 pubmed
Ulbrich S, Kettler A, Einspanier R. Expression and localization of estrogen receptor alpha, estrogen receptor beta and progesterone receptor in the bovine oviduct in vivo and in vitro. J Steroid Biochem Mol Biol. 2003;84:279-89 pubmed
Gopalkrishnan K, Katkam R, Sachdeva G, Kholkute S, Padwal V, Puri C. Effects of an antiprogestin onapristone on the endometrium of bonnet monkeys: morphometric and ultrastructural studies. Biol Reprod. 2003;68:1959-67 pubmed
De Rijk E, Ravesloot W, Hafmans T, van Esch E. Multifocal ductal cell hyperplasia in the submandibular salivary glands of Wistar rats chronically treated with a novel steroidal compound. Toxicol Pathol. 2003;31:1-9 pubmed
Funabashi T, Sano A, Mitsushima D, Kimura F. Bisphenol A increases progesterone receptor immunoreactivity in the hypothalamus in a dose-dependent manner and affects sexual behaviour in adult ovariectomized rats. J Neuroendocrinol. 2003;15:134-40 pubmed
Wu X, Wang H, Englund K, Blanck A, Lindblom B, Sahlin L. Expression of progesterone receptors A and B and insulin-like growth factor-I in human myometrium and fibroids after treatment with a gonadotropin-releasing hormone analogue. Fertil Steril. 2002;78:985-93 pubmed
Gadkar S, Shah C, Sachdeva G, Samant U, Puri C. Progesterone receptor as an indicator of sperm function. Biol Reprod. 2002;67:1327-36 pubmed
Ramos J, Varayoud J, Bosquiazzo V, Luque E, Muñoz de Toro M. Cellular turnover in the rat uterine cervix and its relationship to estrogen and progesterone receptor dynamics. Biol Reprod. 2002;67:735-42 pubmed
Pavao M, Huang Y, Hafer L, Moreland R, Traish A. Immunodetection of nmt55/p54nrb isoforms in human breast cancer. BMC Cancer. 2001;1:15 pubmed
Orimo A, Tomioka Y, Shimizu Y, Sato M, Oigawa S, Kamata K, et al. Cancer-associated myofibroblasts possess various factors to promote endometrial tumor progression. Clin Cancer Res. 2001;7:3097-105 pubmed
Stavreus Evers A, Nikas G, Sahlin L, Eriksson H, Landgren B. Formation of pinopodes in human endometrium is associated with the concentrations of progesterone and progesterone receptors. Fertil Steril. 2001;76:782-91 pubmed
Lantinga van Leeuwen I, van Garderen E, Rutteman G, Mol J. Cloning and cellular localization of the canine progesterone receptor: co-localization with growth hormone in the mammary gland. J Steroid Biochem Mol Biol. 2000;75:219-28 pubmed
Charnock Jones D, Macpherson A, Archer D, Leslie S, Makkink W, Sharkey A, et al. The effect of progestins on vascular endothelial growth factor, oestrogen receptor and progesterone receptor immunoreactivity and endothelial cell density in human endometrium. Hum Reprod. 2000;15 Suppl 3:85-95 pubmed
Badia E, Duchesne M, Semlali A, Fuentes M, Giamarchi C, Richard Foy H, et al. Long-term hydroxytamoxifen treatment of an MCF-7-derived breast cancer cell line irreversibly inhibits the expression of estrogenic genes through chromatin remodeling. Cancer Res. 2000;60:4130-8 pubmed
Lu N, Shlaes T, Gundlah C, Dziennis S, Lyle R, Bethea C. Ovarian steroid action on tryptophan hydroxylase protein and serotonin compared to localization of ovarian steroid receptors in midbrain of guinea pigs. Endocrine. 1999;11:257-67 pubmed
Leach R, Khalifa R, Ramirez N, Das S, Wang J, Dey S, et al. Multiple roles for heparin-binding epidermal growth factor-like growth factor are suggested by its cell-specific expression during the human endometrial cycle and early placentation. J Clin Endocrinol Metab. 1999;84:3355-63 pubmed
Numan M, Roach J, del Cerro M, Guillamon A, Segovia S, Sheehan T, et al. Expression of intracellular progesterone receptors in rat brain during different reproductive states, and involvement in maternal behavior. Brain Res. 1999;830:358-71 pubmed
Shim W, DiRenzo J, DeCaprio J, Santen R, Brown M, Jeng M. Segregation of steroid receptor coactivator-1 from steroid receptors in mammary epithelium. Proc Natl Acad Sci U S A. 1999;96:208-13 pubmed
Spencer T, Mirando M, Mayes J, Watson G, Ott T, Bazer F. Effects of interferon-tau and progesterone on oestrogen-stimulated expression of receptors for oestrogen, progesterone and oxytocin in the endometrium of ovariectomized ewes. Reprod Fertil Dev. 1996;8:843-53 pubmed
Ohta Y, Fukazawa Y, Sato T, Suzuki A, Nishimura N, Iguchi T. Effect of estrogen on ontogenic expression of progesterone and estrogen receptors in rat uterus. Zoolog Sci. 1996;13:143-9 pubmed
Spencer T, Bazer F. Temporal and spatial alterations in uterine estrogen receptor and progesterone receptor gene expression during the estrous cycle and early pregnancy in the ewe. Biol Reprod. 1995;53:1527-43 pubmed
Zheng J, Johnson M, Redmer D, Reynolds L. Estrogen and progesterone receptors, cell proliferation, and c-fos expression in the ovine uterus during early pregnancy. Endocrinology. 1996;137:340-8 pubmed
Ohta Y, Sato T, Iguchi T. Immunocytochemical localization of progesterone receptor in the reproductive tract of adult female rats. Biol Reprod. 1993;48:205-13 pubmed
Spencer T, Becker W, George P, Mirando M, Ogle T, Bazer F. Ovine interferon-tau regulates expression of endometrial receptors for estrogen and oxytocin but not progesterone. Biol Reprod. 1995;53:732-45 pubmed
Traish A, Wotiz H. Monoclonal and polyclonal antibodies to human progesterone receptor peptide-(533-547) recognize a specific site in unactivated (8S) and activated (4S) progesterone receptor and distinguish between intact and proteolyzed receptors. Endocrinology. 1990;127:1167-75 pubmed

product information

Product Type :

Antibody

Product Name :

Progesterone Receptor Monoclonal Antibody (PR-AT 4.14)

Catalog # :

MA1-410

Quantity :

100 ug

Price :

US 491.00

Clonality :

Monoclonal

Purity :

protein A

Host :

Mouse

Reactivity :

Bovine, Human, Mouse, Non-human primate, Rabbit, Rat

Applications :

ChIP Assay: Assay-dependent, Immunohistochemistry (Frozen): 5 ug/mL, Immunohistochemistry (Paraffin): 5 ug/mL, Immunoprecipitation: Assay-dependent, Western Blot: 1:200-1:1,000

Species :

Bovine, Human, Mouse, Non-human primate, Rabbit, Rat

Clone :

PR-AT 4.14

Isotype :

IgG1

Storage :

-20 C, Avoid Freeze/Thaw Cycles

Description :

The progesterone receptor (PR) is a member of the steroid family of nuclear receptors. The PR mediates the physiological effects of progesterone, which plays a central role in reproductive events associated with the establishment and maintenance of pregnancy. PR is found as a 94 kDa protein (Form A) or a 120 kDa protein (Form B) due to the use of alternative translation initiation sites. PR-B is the transcriptionally active form and is responsible for activating genes for the maintenance of the endometrium, maintenance of pregnancy, and inhibition of ovulation. PR-A is identical to PR-B except for a 165 amino acid deletion at the N-terminus. This deletion exposes a 140 amino acid inhibitory domain (ID) that acts as a repressor of steroid hormone transcriptional activity. In its inactive state, PgR forms a multiprotein complex which includes heat shock proteins and immunophins. Upon binding of progesterone hormone to its receptor, there is a conformational change that allows dimerization and binding of the receptor to progesterone response elements (PRE) sequences, resulting in activated transcription. A Null mutation in the PGR gene leads to pleiotrophic reproductive abnormalities.

Immunogen :

Synthetic peptide corresponding to residues G(533) L P Q V Y P P Y L N Y L R P(547) of human Progesterone Receptor.

Format :

Liquid

Applications w/Dilutions :

ChIP Assay: Assay-dependent, Immunohistochemistry (Frozen): 5 ug/mL, Immunohistochemistry (Paraffin): 5 ug/mL, Immunoprecipitation: Assay-dependent, Western Blot: 1:200-1:1,000

Aliases :

9930019P03Rik; BB114106; ENSMUSG00000074510; LOW QUALITY PROTEIN: progesterone receptor; NR3C3; Nuclear receptor subfamily 3 group C member 3; p4 receptor; PGR; pot. alt. progesterone receptor; putative; PR; PR-A; PR-B; Progesterone receptor; progesterone receptor A; progesterone-receptor; putative form B; steroid hormone receptor; testicular progesterone receptor; unnamed protein product