This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
CNF1/CNF2 Monoclonal Antibody (JC4)
catalog :
MA1-40276
quantity :
100 ug
price :
US 622.00
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
JC4
application :
western blot, ELISA
product information
Product Type :
Antibody
Product Name :
CNF1/CNF2 Monoclonal Antibody (JC4)
Catalog # :
MA1-40276
Quantity :
100 ug
Price :
US 622.00
Clonality :
Monoclonal
Purity :
Protein G
Host :
Mouse
Reactivity :
Bacteria
Applications :
ELISA: 1:50, Functional Assay: 1:50, Western Blot: 1:50
Species :
Bacteria
Clone :
JC4
Isotype :
IgG2a
Storage :
4 C
Description :
Cytotoxic necrotizing factor type 1 and 2 (CNF1 & CNF2) belong to a family of bacterial toxins that target the small GTP-binding Rho proteins that regulate the actin cytoskeleton. Members of this toxin family typically inactivate Rho; however, CNF1 and the highly related CNF2 activate Rho by deamidation. CNF1 is more frequently associated with E.coli strains that cause extraintestitinal infections in humans, particularly those of the urinary tract (such as cystitis, pyelonephritis and prostatitis). In CNF1-producing uropathogenic E. coli strains, CNF1 is chromosomally encoded and typically resides on a pathogenicity island that also contains hemolysin and P fimbria- related genes. Both CNF1 and the highly related, plasmid-encoded CNF2 are monomeric, cytoplasmic toxins of approximately 115 kDa. CNF1 can be structurally organized into three functional domains the N-terminal, central and the C-terminal domain. The latter exhibits the catalytic activity of the toxin.
Immunogen :
Residues 169-191 of N-terminus of CNF1.
Format :
Liquid
Applications w/Dilutions :
ELISA: 1:50, Functional Assay: 1:50, Western Blot: 1:50
Aliases :
Cytotoxic necrotizing factor 1; Cytotoxic necrotizing factor 2
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA