Complement C9 Monoclonal Antibody (X197) | Invitrogen MA1-40186 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Complement C9 Monoclonal Antibody (X197)

catalog :

MA1-40186

quantity :

100 ug

price :

US 738.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

X197

The same clone is also sold as:

Novus Biologicals: NBP1-52797
OriGene: AM26242FC-N, AM26242PU-N

reactivity :

human

application :

western blot, ELISA, immunohistochemistry, flow cytometry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section

product information

Product Type :

Antibody

Product Name :

Complement C9 Monoclonal Antibody (X197)

Catalog # :

MA1-40186

Quantity :

100 ug

Price :

US 738.00

Clonality :

Monoclonal

Purity :

Protein G

Host :

Mouse

Reactivity :

Human

Applications :

ELISA: 1:50, Flow Cytometry: 1:50, Functional Assay: 1:50, Immunohistochemistry (Frozen): 1:50, Immunohistochemistry (Paraffin): 1:50, Western Blot: 1:50

Species :

Human

Clone :

X197

Isotype :

IgG1

Storage :

4 C

Description :

C5b-9 membrane attack complexes are assembled from five precursor molecules in the serum. Proteolytic cleavage of C5 by C5 convertase generates C5b which initiates assembly of the C5b-9 complex. The last step of C5b-9 complex formation involves polymerization of C9 which accompanies insertion of the complex into the cell membrane. During formation of C5b-8 and C9 polymerization, neoantigens are generated which are unique to the C5b-9 complex and are not present on any of the individual native complex components. The complement regulatory proteins CD59 and complement S-protein can both prevent C5b-9 insertion into the cell membrane. The formed SC5b-9 complex is unable to attach to cells and is cytolytically inactive. C5b-9 is involved in the progression of chronic proteinuric renal disease by mediating continuous tubulointerstitial damage. Early tubulointerstitial injury in the remnant kidney can be improved when C5b-9 complex forming is abrogated.

Immunogen :

Human C9.

Format :

Liquid

Applications w/Dilutions :

ELISA: 1:50, Flow Cytometry: 1:50, Functional Assay: 1:50, Immunohistochemistry (Frozen): 1:50, Immunohistochemistry (Paraffin): 1:50, Western Blot: 1:50

Aliases :

ARMD15; C9; C9D; complement C9; complement component 9; complement component C9; Complement component C9a; Complement component C9b; complement protein C9; complement protein C9 precursor