Complement C4 Monoclonal Antibody (16D2) | Invitrogen MA1-40047 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Complement C4 Monoclonal Antibody (16D2)

catalog :

MA1-40047

quantity :

100 µg

price :

US 696.00

clonality :

monoclonal

host :

rat

conjugate :

nonconjugated

clone name :

16D2

reactivity :

mouse

application :

western blot, ELISA, immunohistochemistry, immunoprecipitation, immunohistochemistry - frozen section, immunohistochemistry - free floating section

more info or order :

Invitrogen product webpage

citations: 2

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry - free floating section; mouse; 1:25; loading ...; fig 2a	Kaya T, Mattugini N, Liu L, Ji H, Cantuti Castelvetri L, Wu J, et al. CD8+ T cells induce interferon-responsive oligodendrocytes and microglia in white matter aging. Nat Neurosci. 2022;25:1446-1457 pubmed publisher
	Wang C, Xiong M, Gratuze M, Bao X, Shi Y, Andhey P, et al. Selective removal of astrocytic APOE4 strongly protects against tau-mediated neurodegeneration and decreases synaptic phagocytosis by microglia. Neuron. 2021;109:1657-1674.e7 pubmed publisher

product information

Product Type :

Antibody

Product Name :

Complement C4 Monoclonal Antibody (16D2)

Catalog # :

MA1-40047

Quantity :

100 µg

Price :

US 696.00

Clonality :

Monoclonal

Purity :

Protein G

Host :

Rat

Reactivity :

Mouse

Applications :

ELISA: 1:50, Immunohistochemistry (Frozen): 1:50, Immunoprecipitation: 1:50, Western Blot: 1:50

Species :

Mouse

Clone :

16D2

Isotype :

IgG2a

Storage :

4° C

Description :

This gene encodes the acidic form of complement factor 4, part of the classical activation pathway. The protein is expressed as a single chain precursor which is proteolytically cleaved into a trimer of alpha, beta, and gamma chains prior to secretion. The trimer provides a surface for interaction between the antigen-antibody complex and other complement components. The alpha chain may be cleaved to release C4 anaphylatoxin, a mediator of local inflammation. Deficiency of this protein is associated with systemic lupus erythematosus and type I diabetes mellitus. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. Varying haplotypes of this gene cluster exist, such that individuals may have 1, 2, or 3 copies of this gene.

Immunogen :

Thymocytes decorated with Thy-1 antibody and complement components

Format :

Liquid

Applications w/Dilutions :

ELISA: 1:50, Immunohistochemistry (Frozen): 1:50, Immunoprecipitation: 1:50, Western Blot: 1:50

Aliases :

acidic C4; acidic complement C4; Basic complement C4; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 2; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 3; C4; c4 complement; C4-1; C4a; C4a anaphylatoxin; C4A2; C4A3; C4A4; C4A6; C4AD; C4B; C4B_2; C4B1; C4B12; C4B2; C4B3; C4B5; C4b-A; C4b-B; C4BD; C4d-A; C4d-B; C4F; C4S; CH; Chido form of C4; CO4; Complement C4; Complement C4 alpha chain; Complement C4 beta chain; Complement C4 gamma chain; Complement C4-A; Complement C4-A alpha chain; Complement C4-B; Complement C4-B alpha chain; complement C4B1a; complement component 4 (within H-2S); complement component 4, gene 1; complement component 4A (Rodgers blood group); complement component 4B (Chido blood group); complement component 4B (Childo blood group); CPAMD2; CPAMD3; DADB-112B14.11; DAMC-258G8.6; FLJ60561; MGC164979; MHC class III region complement; RG; Rodgers form of C4; sex-limited protein; Slp; Ss

more info or order :

Invitrogen product webpage