Blood Group Lewis A Monoclonal Antibody (SPM 522) | Invitrogen MA1-39426 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Blood Group Lewis A Monoclonal Antibody (SPM 522)

catalog :

MA1-39426

quantity :

1 mL

price :

US 484.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

SPM 522

reactivity :

human

application :

immunohistochemistry, immunohistochemistry - paraffin section

citations: 1

Reference
Brazil J, Sumagin R, Stowell S, Lee G, Louis N, Cummings R, et al. Expression of Lewis-a glycans on polymorphonuclear leukocytes augments function by increasing transmigration. J Leukoc Biol. 2017;102:753-762 pubmed publisher

product information

Product Type :

Antibody

Product Name :

Blood Group Lewis A Monoclonal Antibody (SPM 522)

Catalog # :

MA1-39426

Quantity :

1 mL

Price :

US 484.00

Clonality :

Monoclonal

Purity :

Protein A/G

Host :

Mouse

Reactivity :

Human

Applications :

Immunohistochemistry (Paraffin): 1:200

Species :

Human

Clone :

SPM 522

Isotype :

IgG1

Storage :

Store at 4 C short term. For long term storage, store at -20 C, avoiding freeze/thaw cycles.

Description :

The Lewis histo-blood group system comprises a set of fucosylated glycosphingolipids that are synthesized by exocrine epithelial cells and circulate in body fluids. The glycosphingolipids function in embryogenesis, tissue differentiation, tumor metastasis, inflammation, and bacterial adhesion. They are secondarily absorbed to red blood cells giving rise to their Lewis phenotype. This gene is a member of the fucosyltransferase family, which catalyzes the addition of fucose to precursor polysaccharides in the last step of Lewis antigen biosynthesis. It encodes an enzyme with alpha(1,3)-fucosyltransferase and alpha(1,4)-fucosyltransferase activities. Mutations in this gene are responsible for the majority of Lewis antigen-negative phenotypes. Multiple alternatively spliced variants, encoding the same protein, have been found for this gene.

Immunogen :

Mucin isolated from an ovarian cyst

Format :

Liquid

Applications w/Dilutions :

Immunohistochemistry (Paraffin): 1:200

Aliases :

4-fucosyltransferase; alpha-(1,3/1,4)-fucosyltransferase; blood group Lewis alpha-4-fucosyltransferase; CD174; FT3B; Fucosyltransferase 3; fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group); fucosyltransferase 3 (Lewis blood group); fucosyltransferase III; FucT-III; FUT3; Galactoside 3(4)-L-fucosyltransferase; LE; Les; Lewis FT; Lewis Y