CD146 Monoclonal Antibody (OJ79c), FITC | Invitrogen MA1-35910 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

CD146 Monoclonal Antibody (OJ79c), FITC

catalog :

MA1-35910

quantity :

100 ug

price :

US 918.00

clonality :

monoclonal

host :

mouse

conjugate :

FITC

clone name :

OJ79c

reactivity :

human, dogs, pigs

application :

flow cytometry

more info or order :

Invitrogen product webpage

citations: 1

Published Application/Species/Sample/Dilution	Reference
flow cytometry; human; 1,000 ug/ml; fig 2	Shan X, Chan R, Ng E, Yeung W. Spatial and temporal characterization of endometrial mesenchymal stem-like cells activity during the menstrual cycle. Exp Cell Res. 2017;350:184-189 pubmed publisher

product information

Product Type :

Antibody

Product Name :

CD146 Monoclonal Antibody (OJ79c), FITC

Catalog # :

MA1-35910

Quantity :

100 ug

Price :

US 918.00

Clonality :

Monoclonal

Purity :

purified

Host :

Mouse

Reactivity :

Canine, Human, Porcine

Applications :

Flow Cytometry: Assay-dependent

Species :

Canine, Human, Porcine

Clone :

OJ79c

Isotype :

IgG1

Storage :

4 C, store in dark

Description :

CD146 (MCAM) is an integral membrane glycoprotein belonging to the immunoglobulin superfamily. CD146 is expressed at cell-cell junctions in all endothelial cells, and has also been observed in other normal and malignant cell types. In addition to its recognized role as a calcium-independent cell adhesion molecule, CD146 may also act as a signal transduction molecule in the recruitment of Fyn kinase, and in the subsequent tyrosine-phosphorylation of intracellular proteins involved in actin cytoskeleton assembly. CD146 plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. CD146 expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread. Further, CD146 could be an adhesion molecule active in neural crest cells during embryonic development. CD146 acts also as surface receptor that triggers tyrosine phosphorylation of FYN and PTK2, and a transient increase in the intracellular calcium concentration.

Immunogen :

Recombinant human MUC18 (D1-D5) Fc protein.

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: Assay-dependent

Aliases :

1-gicerin; AV025631; CD146; CD149; Cell surface glycoprotein MUC18; cell surface glycoprotein P1H12; Gicerin; HEMCAM; l-gicerin; l-gicerin precursor; l-gicerin protein; LOW QUALITY PROTEIN: cell surface glycoprotein MUC18; MCAM; melanoma adhesion molecule; melanoma cell adhesion molecule; Melanoma-associated antigen A32; melanoma-associated antigen MUC18; Muc18; mucin-18; s-endo; S-endo 1 endothelial-associated antigen; s-gicerin; s-gicerin precursor

more info or order :

Invitrogen product webpage