MRP5 Monoclonal Antibody (M5II-54) | Invitrogen MA1-35684 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

MRP5 Monoclonal Antibody (M5II-54)

catalog :

MA1-35684

quantity :

1 mL

price :

US 626.00

clonality :

monoclonal

host :

rat

conjugate :

nonconjugated

clone name :

M5II-54

The same clone is also sold as:

OriGene: AM32043SU-N
Abcam: ab24107

reactivity :

human

application :

western blot, immunohistochemistry, immunocytochemistry, flow cytometry, immunohistochemistry - frozen section

citations: 1

Reference
He J, Bugde P, Li J, Biswas R, Li S, Yang X, et al. Multidrug resistance protein 5 affects cell proliferation, migration and gemcitabine sensitivity in pancreatic cancer MIA Paca‑2 and PANC‑1 cells. Oncol Rep. 2024;51: pubmed publisher

product information

Product Type :

Antibody

Product Name :

MRP5 Monoclonal Antibody (M5II-54)

Catalog # :

MA1-35684

Quantity :

1 mL

Price :

US 626.00

Clonality :

Monoclonal

Host :

Rat

Reactivity :

Human

Applications :

Flow Cytometry: Assay-dependent, Immunocytochemistry: 1:20-1:50, Immunohistochemistry (Frozen): 1:20, Western Blot: 1:50

Species :

Human

Clone :

M5II-54

Isotype :

IgG2a

Storage :

4 C

Description :

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions in the cellular export of its substrate, cyclic nucleotides. This export contributes to the degradation of phosphodiesterases and possibly an elimination pathway for cyclic nucleotides. Studies show that this protein provides resistance to thiopurine anticancer drugs, 6-mercatopurine and thioguanine, and the anti-HIV drug 9-(2-phosphonylmethoxyethyl)adenine. This protein may be involved in resistance to thiopurines in acute lymphoblastic leukemia and antiretroviral nucleoside analogs in HIV-infected patients. Alternative splicing of this gene has been detected; however, the complete sequence and translation initiation site is unclear.

Immunogen :

MRP5 aa 722-910

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: Assay-dependent, Immunocytochemistry: 1:20-1:50, Immunohistochemistry (Frozen): 1:20, Western Blot: 1:50

Aliases :

2900011L11Rik; ABC 33; ABC33; ABCC 5; ABCC5; Abcc5a; Abcc5b; AI132311; ATP binding cassette subfamily C member 5; ATP-binding cassette sub-family C (CFTR/MRP) member 5a; ATP-binding cassette sub-family C member 5; ATP-binding cassette, subfamily C (CFTR/MRP), member 5; ATP-binding cassette, sub-family C (CFTR/MRP), member 5; ATP-binding cassette, sub-family C (CFTR/MRP), member 5a; ATP-binding cassette, sub-family C (CFTR/MRP), member 5b; ATP-binding cassette, sub-family C, member 5; canalicular multispecific organic anion transporter C; DKFZp686C1782; EST277145; MOAT C; MOATC; MOAT-C; MRP 5; MRP5; multidrug resistance-associated protein 5; Multi-specific organic anion transporter C; pABC 11; pABC11; SMRP