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company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
HLA-B Monoclonal Antibody (JOAN-1)
catalog :
MA1-35410
quantity :
100 µg
price :
US 474
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
JOAN-1
reactivity :
human
application :
immunohistochemistry, flow cytometry, immunohistochemistry - frozen section, blocking or activating experiments
more info or order :
Invitrogen product webpage
citations: 7
Published Application/Species/Sample/DilutionReference
  • blocking or activating experiments; human; 10 ug/ml
Zal B, Kaski J, Akiyu J, Cole D, Arno G, Poloniecki J, et al. Differential pathways govern CD4+ CD28- T cell proinflammatory and effector responses in patients with coronary artery disease. J Immunol. 2008;181:5233-41 pubmed
  • flow cytometry; human
Hühn M, Hultcrantz M, Lind K, Ljunggren H, Malmberg K, Flodstrom Tullberg M. IFN-gamma production dominates the early human natural killer cell response to Coxsackievirus infection. Cell Microbiol. 2008;10:426-36 pubmed
  • flow cytometry; human
Guerreiro Cacais A, Uzunel M, Levitskaya J, Levitsky V. Inhibition of heavy chain and beta2-microglobulin synthesis as a mechanism of major histocompatibility complex class I downregulation during Epstein-Barr virus replication. J Virol. 2007;81:1390-400 pubmed
Qaiser M, Dolman D, Begley D, Abbott N, Cazacu Davidescu M, Corol D, et al. Uptake and metabolism of sulphated steroids by the blood-brain barrier in the adult male rat. J Neurochem. 2017;142:672-685 pubmed publisher
Ryschich E, Cebotari O, Fabian O, Autschbach F, Kleeff J, Friess H, et al. Loss of heterozygosity in the HLA class I region in human pancreatic cancer. Tissue Antigens. 2004;64:696-702 pubmed
Sun J, Senitzer D, Forman S, Chatterjee S, Wong K. Identification of new MHC-restriction elements for presentation of the p210(BCR-ABL) fusion region to human cytotoxic T lymphocytes. Cancer Immunol Immunother. 2003;52:761-70 pubmed
Park B, Lee S, Kim E, Ahn K. A single polymorphic residue within the peptide-binding cleft of MHC class I molecules determines spectrum of tapasin dependence. J Immunol. 2003;170:961-8 pubmed
product information
Product Type :
Antibody
Product Name :
HLA-B Monoclonal Antibody (JOAN-1)
Catalog # :
MA1-35410
Quantity :
100 µg
Price :
US 474
Clonality :
Monoclonal
Purity :
purified
Host :
Mouse
Reactivity :
Human, Mouse
Applications :
Immunohistochemistry (Frozen): 1-2 µg/mL
Species :
Human, Mouse
Clone :
JOAN-1
Isotype :
IgG1
Storage :
4° C
Description :
HLA-B belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide, exon 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Hundreds of HLA-B alleles have been described. HLA and MHC antibodies play a significant role in Immunopeptidomics, facilitating the identification and characterization of neoantigens through high-performance liquid chromatography coupled to tandem Mass Spectrometry.
Immunogen :
Human peripheral blood lymphocytes.
Format :
Liquid
Applications w/Dilutions :
Immunohistochemistry (Frozen): 1-2 µg/mL
Aliases :
A29 protein; antigen presenting molecule; AS; Aw-33; Aw-74; B-4901; B-5001; Bw-47; Bw-50; class I MHC, HLA-B antigen; DAQB-90C11.16; epididymis secretory protein Li 83; FLJ26655; HEL-S-83; histocompatibility antigen; HLA A; HLA -B; HLA B-40011; HLA B44; HLA class I antigen; HLA class I antigen HLA-B; HLA class I histocompatibility antigen, A alpha chain; HLA class I histocompatibility antigen, A-1 alpha chain; HLA class I histocompatibility antigen, A-30 alpha chain; HLA class I histocompatibility antigen, A-33 alpha chain; HLA class I histocompatibility antigen, A-74 alpha chain; HLA class I histocompatibility antigen, B alpha chain; HLA class I histocompatibility antigen, B-47 alpha chain; HLA class I histocompatibility antigen, B-50 alpha chain; HLA class I histocompatibility antigen, B-82 alpha chain; HLA locus; HLA molecule; HLAA; HLA-A; HLA-A locus alpha 2 domain; HLA-A null; HLA-A11; HLA-A33; HLA-Aw33.1; HLAB; HLA-B; HLA-B 1502; HLA-B alpha chain; HLA-B alpha chain (B*2706); HLA-B alpha chain (B*5002); HLA-B alpha-chain; HLA-B*45ZJ; HLA-B15; HLA-B35; HLA-B35 antigen; HLA-B-3506; HLA-B39; HLA-B-3905; HLA-B49; HLA-B50; HLA-B55; HLA-B-5502; HLA-B-5602; HLA-B59; HLA-B61; HLA-Bw50 antigen; HLA-Cw; HLA-DQB1; HLA-DRB1; Human leukocyte antigen A; hypothetical protein; lecocyte antigen B; leukocyt; Leukocyte Antigen; leukocyte antigen class I-A; leukocyte antigen class I-B; Leukoocyte Antigen; lymphocyte antigen; major histocompatability complex B antigen; major histocompatibility complex, class I, A; major histocompatibility complex, class I, B; MCH class I antigen; MHC 1; MHC antigen; MHC class 1 antigen; MHC class I alpha chain; MHC class I anitgen; MHC class I anti; MHC Class I antigen; MHC class I antigen A*30; MHC class I antigen A*33; MHC class I antigen A*74; MHC class I antigen B*47; MHC class I antigen B*50; MHC class I antigen B*82; MHC class I antigen GN00104; MHC class I antigen heavy chain; MHC class I antigen HLA-A heavy chain; MHC class I antigen HLA-A33; MHC class I antigen HLA-B alpha chain; MHC class I antigen HLA-B heavy chain; MHC class I antigen null protein; MHC class I antigen SHCHA; MHC class I antigene; MHC class I human leukocyte antigen; MHC class I molecule; MHC class I protein; MHC class II antigen; MHC class l antigen; MHC classI antigen; MHC HLA-B cell surface glycoprotein; MHC HLA-B transmembrane glycoprotein; MHC HLA-B27d; MHC HLA-B27-HS; MHC HLA-B39N; MHC1; SPDA1; truncated class I antigen; truncated MHC class I antigen
more info or order :
Invitrogen product webpage
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA