Blood Group H Type 2 Monoclonal Antibody (19-OLE) | Invitrogen MA1-35386 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Blood Group H Type 2 Monoclonal Antibody (19-OLE)

catalog :

MA1-35386

quantity :

100 ug

price :

US 500.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

19-OLE

reactivity :

human

application :

immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section

product information

Product Type :

Antibody

Product Name :

Blood Group H Type 2 Monoclonal Antibody (19-OLE)

Catalog # :

MA1-35386

Quantity :

100 ug

Price :

US 500.00

Clonality :

Monoclonal

Purity :

purified

Host :

Mouse

Reactivity :

Human

Applications :

Immunocytochemistry: Assay-dependent, Immunohistochemistry (Frozen): Assay-dependent, Immunohistochemistry (Paraffin): Assay-dependent

Species :

Human

Clone :

19-OLE

Isotype :

IgM

Storage :

4 C

Description :

The H antigen is a precursor to the ABO blood groupantigens, present in people of all common blood types. The Bombay phenotype (hh) does not express antigen H on red blood cells, and therefore this type will also lack A or B antigens, similar to the O blood group. However, unlike O group, the H antigen is absent, hence the individuals produce isoantibodies to antigen H as well as to both A and B antigens. If they receive blood from someone with O blood group, the anti-H antibodies will bind to the H antigen on the red blood cells of the donor blood and destroy the RBCs bycomplement-mediated lysis. Therefore, people with Bombay phenotype can receive blood only from otherhhdonors, although they can donate as though they were type O. Some individuals with the blood group A1 may also be able to produce anti-H antibodies due to the complete conversion of all the H antigen to A1 antigen. Production of the H antigen, or its deficiency in the Bombay phenotype, is controlled at the H locus on chromosome 19. The H locus contains threeexonsthat span more than 5kbof genomic DNA, and encodes thefucosyltransferasethat produces the H antigen on RBCs. The H antigen is a carbohydrate sequence withcarbohydrateslinked mainly to protein (with a minor fraction attached toceramidemoiety).

Immunogen :

Mucin isolated from a mucinous colonic adenocarcinoma

Format :

Liquid

Applications w/Dilutions :

Immunocytochemistry: Assay-dependent, Immunohistochemistry (Frozen): Assay-dependent, Immunohistochemistry (Paraffin): Assay-dependent

Aliases :

ABH; BG-H; BG-H1