This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
CD45RO Monoclonal Antibody (UCHL1)
catalog :
MA1-33243
quantity :
1 mL
price :
US 399.00
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
UCHL1
reactivity :
human, mouse
application :
immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section
citations: 50
Published Application/Species/Sample/DilutionReference
  • immunohistochemistry; human; fig 4g
Liu X, Kong W, Peterson C, McGrail D, Hoang A, Zhang X, et al. PBRM1 loss defines a nonimmunogenic tumor phenotype associated with checkpoint inhibitor resistance in renal carcinoma. Nat Commun. 2020;11:2135 pubmed publisher
  • flow cytometry; human; loading ...; fig e4d
Lynn R, Weber E, Sotillo E, Gennert D, Xu P, Good Z, et al. c-Jun overexpression in CAR T cells induces exhaustion resistance. Nature. 2019;576:293-300 pubmed publisher
  • flow cytometry; human; loading ...; fig 1b
Pizzolla A, Nguyen T, Sant S, Jaffar J, Loudovaris T, Mannering S, et al. Influenza-specific lung-resident memory T cells are proliferative and polyfunctional and maintain diverse TCR profiles. J Clin Invest. 2018;128:721-733 pubmed publisher
  • flow cytometry; human; loading ...; fig 1a
Schulten V, Tripple V, Seumois G, Qian Y, Scheuermann R, Fu Z, et al. Allergen-specific immunotherapy modulates the balance of circulating Tfh and Tfr cells. J Allergy Clin Immunol. 2018;141:775-777.e6 pubmed publisher
  • flow cytometry; human; loading ...; fig 3b
Szabo P, Goswami A, Mazzuca D, Kim K, O Gorman D, Hess D, et al. Rapid and Rigorous IL-17A Production by a Distinct Subpopulation of Effector Memory T Lymphocytes Constitutes a Novel Mechanism of Toxic Shock Syndrome Immunopathology. J Immunol. 2017;198:2805-2818 pubmed publisher
  • immunohistochemistry - frozen section; human; loading ...; tbl 2
Perea F, Bernal M, Sánchez Palencia A, Carretero J, Torres C, Bayarri C, et al. The absence of HLA class I expression in non-small cell lung cancer correlates with the tumor tissue structure and the pattern of T cell infiltration. Int J Cancer. 2017;140:888-899 pubmed publisher
  • flow cytometry; human; loading ...; fig s3b
Komdeur F, Wouters M, Workel H, Tijans A, Terwindt A, Brunekreeft K, et al. CD103+ intraepithelial T cells in high-grade serous ovarian cancer are phenotypically diverse TCRαβ+ CD8αβ+ T cells that can be targeted for cancer immunotherapy. Oncotarget. 2016;7:75130-75144 pubmed publisher
  • immunohistochemistry; human
Däster S, Eppenberger Castori S, Hirt C, Zlobec I, Delko T, Nebiker C, et al. High frequency of CD8 positive lymphocyte infiltration correlates with lack of lymph node involvement in early rectal cancer. Dis Markers. 2014;2014:792183 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:100
Yang Y, Li Y, Liu Y, Yang M, Liu K. CD30+ extranodal natural killer/T-cell lymphoma mimicking phlegmonous myositis: A case report. Oncol Lett. 2014;7:1419-1421 pubmed
  • immunohistochemistry; human
Mungan S, Karaguzel E, Turan C, Reis A. A giant primary sclerosing lipogranuloma of the scrotum. Turk Patoloji Derg. 2014;30:78-80 pubmed publisher
  • immunohistochemistry; human
Makkai Popa S, Lunca S, Dimofte G, Vranceanu A, Franciug D, Ivanov I, et al. Corelation of lymphocytic infiltrates with the prognosis of recurrent colo-rectal cancer. Chirurgia (Bucur). 2013;108:859-65 pubmed
  • flow cytometry; human
Ammirati E, Cianflone D, Vecchio V, Banfi M, Vermi A, De Metrio M, et al. Effector Memory T cells Are Associated With Atherosclerosis in Humans and Animal Models. J Am Heart Assoc. 2012;1:27-41 pubmed publisher
  • immunohistochemistry; human
Macedo C, Walters J, Orkis E, Isse K, Elinoff B, Fedorek S, et al. Long-term effects of alemtuzumab on regulatory and memory T-cell subsets in kidney transplantation. Transplantation. 2012;93:813-21 pubmed publisher
  • immunohistochemistry - paraffin section; human; tbl 4
Yang H, Xu C, Tang Y, Wan C, Liu W, Wang L. The significance of multiplex PCR/heteroduplex analysis-based TCR-? gene rearrangement combined with laser-capture microdissection in the diagnosis of early mycosis fungoides. J Cutan Pathol. 2012;39:337-46 pubmed publisher
  • flow cytometry; human; fig 1
Imataki O, Ansén S, Tanaka M, Butler M, Berezovskaya A, Milstein M, et al. IL-21 can supplement suboptimal Lck-independent MAPK activation in a STAT-3-dependent manner in human CD8(+) T cells. J Immunol. 2012;188:1609-19 pubmed publisher
  • flow cytometry; human; 1:100; tbl 3
Su X, Huang J, Jiang Y, Tang Y, Li G, Liu W. Serous effusion cytology of extranodal natural killer/T-cell lymphoma. Cytopathology. 2012;23:96-102 pubmed publisher
  • immunohistochemistry; mouse
Honma Y, Kawano M, Kohsaka S, Ogawa M. Axonal projections of mechanoreceptive dorsal root ganglion neurons depend on Ret. Development. 2010;137:2319-28 pubmed publisher
  • immunohistochemistry; human; 1:1000
Belousova I, Vanecek T, Samtsov A, Michal M, Kazakov D. A patient with clinicopathologic features of small plaque parapsoriasis presenting later with plaque-stage mycosis fungoides: report of a case and comparative retrospective study of 27 cases of "nonprogressive" small plaque parapsoriasis. J Am Acad Dermatol. 2008;59:474-82 pubmed publisher
  • immunohistochemistry; human; 1:1000
Kazakov D, Belousova I, Kacerovska D, Sima R, Vanecek T, Vazmitel M, et al. Hyperplasia of hair follicles and other adnexal structures in cutaneous lymphoproliferative disorders: a study of 53 cases, including so-called pseudolymphomatous folliculitis and overt lymphomas. Am J Surg Pathol. 2008;32:1468-78 pubmed publisher
  • flow cytometry; human; fig 2
Yates J, Whittington A, Mitchell P, Lechler R, Lightstone L, Lombardi G. Natural regulatory T cells: number and function are normal in the majority of patients with lupus nephritis. Clin Exp Immunol. 2008;153:44-55 pubmed publisher
  • immunocytochemistry; human; 1:2500
Carolan B, Heguy A, Harvey B, Leopold P, Ferris B, Crystal R. Up-regulation of expression of the ubiquitin carboxyl-terminal hydrolase L1 gene in human airway epithelium of cigarette smokers. Cancer Res. 2006;66:10729-40 pubmed
  • immunohistochemistry; human; 1:1000
Boudova L, Kazakov D, Jindra P, Sima R, Vanecek T, Kuntscher V, et al. Primary cutaneous histiocyte and neutrophil-rich CD30+ and CD56+ anaplastic large-cell lymphoma with prominent angioinvasion and nerve involvement in the forehead and scalp of an immunocompetent woman. J Cutan Pathol. 2006;33:584-9 pubmed
  • flow cytometry; human
Hoves S, Krause S, Schutz C, Halbritter D, Scholmerich J, Herfarth H, et al. Monocyte-derived human macrophages mediate anergy in allogeneic T cells and induce regulatory T cells. J Immunol. 2006;177:2691-8 pubmed
  • immunohistochemistry; human; 1:1000
Boudova L, Kazakov D, Sima R, Vanecek T, Torlakovic E, Lamovec J, et al. Cutaneous lymphoid hyperplasia and other lymphoid infiltrates of the breast nipple: a retrospective clinicopathologic study of fifty-six patients. Am J Dermatopathol. 2005;27:375-86 pubmed
  • flow cytometry; human; fig 1
Thompson S, Luyrink L, Graham T, Tsoras M, Ryan M, Passo M, et al. Chemokine receptor CCR4 on CD4+ T cells in juvenile rheumatoid arthritis synovial fluid defines a subset of cells with increased IL-4:IFN-gamma mRNA ratios. J Immunol. 2001;166:6899-906 pubmed
  • flow cytometry; human
Lee B, Sharron M, Montaner L, Weissman D, Doms R. Quantification of CD4, CCR5, and CXCR4 levels on lymphocyte subsets, dendritic cells, and differentially conditioned monocyte-derived macrophages. Proc Natl Acad Sci U S A. 1999;96:5215-20 pubmed
  • flow cytometry; human; fig 4
Kim C, Pelus L, White J, Applebaum E, Johanson K, Broxmeyer H. CK beta-11/macrophage inflammatory protein-3 beta/EBI1-ligand chemokine is an efficacious chemoattractant for T and B cells. J Immunol. 1998;160:2418-24 pubmed
  • immunohistochemistry - frozen section; human; fig 1
  • flow cytometry; human
  • immunoprecipitation; human; fig 2
Smith S, Brown M, Rowe D, Callard R, Beverley P. Functional subsets of human helper-inducer cells defined by a new monoclonal antibody, UCHL1. Immunology. 1986;58:63-70 pubmed
Ham S, Lee D, Xu W, Cho E, Choi S, Min S, et al. Loss of UCHL1 rescues the defects related to Parkinson's disease by suppressing glycolysis. Sci Adv. 2021;7: pubmed publisher
Chen C, Qin H, Tang J, Hu Z, Tan J, Zeng L. USP30 protects against oxygen-glucose deprivation/reperfusion induced mitochondrial fragmentation and ubiquitination and degradation of MFN2. Aging (Albany NY). 2021;13:6194-6204 pubmed publisher
Shao A, Lin D, Wang L, Tu S, Lenahan C, Zhang J. Oxidative Stress at the Crossroads of Aging, Stroke and Depression. Aging Dis. 2020;11:1537-1566 pubmed publisher
Nakano M, Riku Y, Nishioka K, Hasegawa M, Washimi Y, Arahata Y, et al. Unclassified four-repeat tauopathy associated with familial parkinsonism and progressive respiratory failure. Acta Neuropathol Commun. 2020;8:148 pubmed publisher
Kepchia D, Huang L, Dargusch R, Rissman R, Shokhirev M, Fischer W, et al. Diverse proteins aggregate in mild cognitive impairment and Alzheimer's disease brain. Alzheimers Res Ther. 2020;12:75 pubmed publisher
Ng A, Tan Y, Lu Z, Ng E, Ng S, Chia N, et al. Plasma ubiquitin C-terminal hydrolase L1 levels reflect disease stage and motor severity in Parkinson's disease. Aging (Albany NY). 2020;12:1488-1495 pubmed publisher
Zarak Crnkovic M, Kania G, Jazwa Kusior A, Czepiel M, Wijnen W, Czyz J, et al. Heart non-specific effector CD4+ T cells protect from postinflammatory fibrosis and cardiac dysfunction in experimental autoimmune myocarditis. Basic Res Cardiol. 2019;115:6 pubmed publisher
Singh M, Kasna S, Roy S, Aldosary S, Saeedan A, Ansari M, et al. Repurposing mechanistic insight of PDE-5 inhibitor in cancer chemoprevention through mitochondrial-oxidative stress intervention and blockade of DuCLOX signalling. BMC Cancer. 2019;19:996 pubmed publisher
Mielke L, Liao Y, Clemens E, Firth M, Duckworth B, Huang Q, et al. TCF-1 limits the formation of Tc17 cells via repression of the MAF-RORγt axis. J Exp Med. 2019;: pubmed publisher
Logtenberg M, Jansen J, Raaben M, Toebes M, Franke K, Brandsma A, et al. Glutaminyl cyclase is an enzymatic modifier of the CD47- SIRPα axis and a target for cancer immunotherapy. Nat Med. 2019;25:612-619 pubmed publisher
Fu H, Zhang W, Yuan Q, Niu M, Zhou F, Qiu Q, et al. PAK1 Promotes the Proliferation and Inhibits Apoptosis of Human Spermatogonial Stem Cells via PDK1/KDR/ZNF367 and ERK1/2 and AKT Pathways. Mol Ther Nucleic Acids. 2018;12:769-786 pubmed publisher
Augustin H, McGourty K, Allen M, Adcott J, Wong C, Boucrot E, et al. Impact of insulin signaling and proteasomal activity on physiological output of a neuronal circuit in aging Drosophila melanogaster. Neurobiol Aging. 2018;66:149-157 pubmed publisher
Müller N, Landwehr K, Langeveld K, Stenzel J, Pouwels W, van der Hoorn M, et al. Generation of alloreactivity-reduced donor lymphocyte products retaining memory function by fully automatic depletion of CD45RA-positive cells. Cytotherapy. 2018;20:532-542 pubmed publisher
Laksono B, Grosserichter Wagener C, de Vries R, Langeveld S, Brem M, van Dongen J, et al. In Vitro Measles Virus Infection of Human Lymphocyte Subsets Demonstrates High Susceptibility and Permissiveness of both Naive and Memory B Cells. J Virol. 2018;92: pubmed publisher
Lamere S, Thompson R, Meng X, Komori H, Mark A, Salomon D. H3K27 Methylation Dynamics during CD4 T Cell Activation: Regulation of JAK/STAT and IL12RB2 Expression by JMJD3. J Immunol. 2017;199:3158-3175 pubmed publisher
Gao H, Hartnett S, Li Y. Ubiquitin C-Terminal Hydrolase L1 regulates myoblast proliferation and differentiation. Biochem Biophys Res Commun. 2017;492:96-102 pubmed publisher
Hegazy A, West N, Stubbington M, Wendt E, Suijker K, Datsi A, et al. Circulating and Tissue-Resident CD4+ T Cells With Reactivity to Intestinal Microbiota Are Abundant in Healthy Individuals and Function Is Altered During Inflammation. Gastroenterology. 2017;153:1320-1337.e16 pubmed publisher
Costa N, Marques O, Godinho S, Carvalho C, Leal B, Figueiredo A, et al. Two separate effects contribute to regulatory T cell defect in systemic lupus erythematosus patients and their unaffected relatives. Clin Exp Immunol. 2017;189:318-330 pubmed publisher
Chen H, Händel N, Ngeow J, Muller J, Huhn M, Yang H, et al. Immune dysregulation in patients with PTEN hamartoma tumor syndrome: Analysis of FOXP3 regulatory T cells. J Allergy Clin Immunol. 2017;139:607-620.e15 pubmed publisher
Schmitt N, Liu Y, Bentebibel S, Munagala I, Bourdery L, Venuprasad K, et al. The cytokine TGF-? co-opts signaling via STAT3-STAT4 to promote the differentiation of human TFH cells. Nat Immunol. 2014;15:856-65 pubmed publisher
Aki H, Tuzuner N, Ongoren S, Baslar Z, Soysal T, Ferhanoglu B, et al. T-cell-rich B-cell lymphoma: a clinicopathologic study of 21 cases and comparison with 43 cases of diffuse large B-cell lymphoma. Leuk Res. 2004;28:229-36 pubmed
Kim C, Rott L, Clark Lewis I, Campbell D, Wu L, Butcher E. Subspecialization of CXCR5+ T cells: B helper activity is focused in a germinal center-localized subset of CXCR5+ T cells. J Exp Med. 2001;193:1373-81 pubmed
product information
Product Type :
Antibody
Product Name :
CD45RO Monoclonal Antibody (UCHL1)
Catalog # :
MA1-33243
Quantity :
1 mL
Price :
US 399.00
Clonality :
Monoclonal
Purity :
IgG fraction
Host :
Mouse
Reactivity :
Human
Applications :
Immunohistochemistry (Paraffin): 1:25-1:50
Species :
Human
Clone :
UCHL1
Isotype :
IgG2a
Storage :
4° C, do not freeze
Description :
CD45RO (UCHL1, ubiquitin carboxyl terminal esterase L1) is the shortest isoform of a receptor-type protein tyrosine phosphatase, CD45 glycoprotein. CD45 is crucial in lymphocyte development and antigen signaling, serving as an important regulator of Src-family kinases, promotes cell survival by modulating integrin-mediated signal transduction pathway and is also involved in DNA fragmentation during apoptosis. CD45 isoforms differ in their extracellular domains, whereas they share identical transmembrane and cytoplasmic domains. CD45 isoforms differ in their ability to translocate into the glycosphingolipid-enriched membrane domains and their expression depends on cell type and physiological state of the cell. CD45RO is expressed on macrophages, CD8+ T cells, activated T cells and myeloma cells. Besides the role in immunoreceptor signaling, CD45 is important in promoting cell survival by modulating integrin-mediated signal transduction pathway and is also involved in DNA fragmentation during apoptosis.
Immunogen :
IL-2 dependent T cell line, CA1.
Format :
Liquid
Applications w/Dilutions :
Immunohistochemistry (Paraffin): 1:25-1:50
Aliases :
B220; Cd45; CD45 antigen; CD45R; GP180; Lca; L-CA; leucocyte common antigen; leukocyte common antigen; leukocyte common antigen A; leukocyte common antigen B; loc; LY5; Ly-5; lymphocyte antigen 5; lymphocyte common antigen; Lyt-4; membrane tyrosine phosphatase; protein tyrosine phosphatase receptor type C; protein tyrosine phosphatase, receptor type C; protein tyrosine phosphatase, receptor type, C; protein tyrosine phosphatase, receptor type, c polypeptide; Protein tyrosine phosphatase, receptor-type, c polypeptide; PTPRC; Receptor-type tyrosine-protein phosphatase C; RT7; T200; T200 glycoprotein; T200 leukocyte common antigen
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA