beta Catenin Monoclonal Antibody (15B8) | Invitrogen MA1-301 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

beta Catenin Monoclonal Antibody (15B8)

catalog :

MA1-301

quantity :

100 ug

price :

US 562.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

15B8

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, immunohistochemistry - paraffin section

more info or order :

Invitrogen product webpage

citations: 15

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry - paraffin section; human; 1:500	da Silva S, Morand G, Alobaid F, Hier M, Mlynarek A, Alaoui Jamali M, et al. Epithelial-mesenchymal transition (EMT) markers have prognostic impact in multiple primary oral squamous cell carcinoma. Clin Exp Metastasis. 2015;32:55-63 pubmed publisher
	Bowler Barnett E, Martinez Garcia F, Sherwood M, Aleidan A, John S, Weston S, et al. Proteomic characterization of GSK3β knockout shows altered cell adhesion and metabolic pathway utilisation in colorectal cancer cells. PLoS ONE. 2021;16:e0246707 pubmed publisher
	Zeng J, Ma X, Zhao Z, Chen Y, Wang J, Hao Y, et al. Ginsenoside Rb1 Lessens Gastric Precancerous Lesions by Interfering With β-Catenin/TCF4 Interaction. Front Pharmacol. 2021;12:682713 pubmed publisher
	Li D, Chen L, Zhang X, Wang Y, Huang C, Li J, et al. miR‑125a‑5p reverses epithelial‑mesenchymal transition and restores drug sensitivity by negatively regulating TAFAZZIN signaling in breast cancer. Mol Med Rep. 2021;24: pubmed publisher
	Deng Q, Wu L, Li Y, Zou L. MYBL2 in synergy with CDC20 promotes the proliferation and inhibits apoptosis of gastric cancer cells. Adv Clin Exp Med. 2021;30:957-966 pubmed publisher
	Illendula A, Fultang N, Peethambaran B. Retinoic acid induces differentiation in neuroblastoma via ROR1 by modulating retinoic acid response elements. Oncol Rep. 2020;44:1013-1024 pubmed publisher
	Chen K, Phan T, Lin A, Sardo L, Mele A, Nonnemacher M, et al. Morphine exposure exacerbates HIV-1 Tat driven changes to neuroinflammatory factors in cultured astrocytes. PLoS ONE. 2020;15:e0230563 pubmed publisher
	Liu T, Zhou L, Yang K, Iwasawa K, Kadekaro A, Takebe T, et al. The β-catenin/YAP signaling axis is a key regulator of melanoma-associated fibroblasts. Signal Transduct Target Ther. 2019;4:63 pubmed publisher
	Bowler E, Smith Vidal A, Lester A, Bell J, Wang Z, Bell C, et al. Deep proteomic analysis of Dnmt1 mutant/hypomorphic colorectal cancer cells reveals dysregulation of epithelial-mesenchymal transition and subcellular re-localization of Beta-Catenin. Epigenetics. 2020;15:107-121 pubmed publisher
	Fultang N, Illendula A, Chen B, Wu C, Jonnalagadda S, BAIRD N, et al. Strictinin, a novel ROR1-inhibitor, represses triple negative breast cancer survival and migration via modulation of PI3K/AKT/GSK3ß activity. PLoS ONE. 2019;14:e0217789 pubmed publisher
	Shukla M, Ganguli N, Sen Sharma S, Majumdar S. Sertoli cell specific decline in NOR-1 leads to germ cell apoptosis and reduced fertility. J Cell Biochem. 2018;119:6514-6526 pubmed publisher
	Hadjadj D, Kim S, Denecker T, Ben Driss L, Cadoret J, Maric C, et al. A hypothesis-driven approach identifies CDK4 and CDK6 inhibitors as candidate drugs for treatments of adrenocortical carcinomas. Aging (Albany NY). 2017;9:2695-2716 pubmed publisher
	Advedissian T, Proux Gillardeaux V, Nkosi R, Peyret G, Nguyen T, Poirier F, et al. E-cadherin dynamics is regulated by galectin-7 at epithelial cell surface. Sci Rep. 2017;7:17086 pubmed publisher
	Sato H, Coburn J. Leptospira interrogans causes quantitative and morphological disturbances in adherens junctions and other biological groups of proteins in human endothelial cells. PLoS Negl Trop Dis. 2017;11:e0005830 pubmed publisher
	Zhou L, Yang K, Xu M, Andl T, Millar S, Boyce S, et al. Activating β-catenin signaling in CD133-positive dermal papilla cells increases hair inductivity. FEBS J. 2016;283:2823-35 pubmed publisher

product information

Product Type :

Antibody

Product Name :

beta Catenin Monoclonal Antibody (15B8)

Catalog # :

MA1-301

Quantity :

100 ug

Price :

US 562.00

Clonality :

Monoclonal

Purity :

protein A

Host :

Mouse

Reactivity :

Human, Mouse, Non-human primate, Rat

Applications :

Gel Shift: Assay-dependent, Immunocytochemistry: 1:50-1:1,000, Immunohistochemistry (Paraffin): 1:100-1:1,000, Immunoprecipitation: Assay-dependent, Western Blot: 1:500-1:1,000

Species :

Human, Mouse, Non-human primate, Rat

Clone :

15B8

Storage :

-20 C, Avoid Freeze/Thaw Cycles

Description :

Beta-catenin, an adherens junction (AJ) protein, was originally identified as a component of cell-cell adhesion structures. AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. Beta-catenin interacts with the cytoplasmic domain of E-cadherin and links E-cadherin to alpha-catenin, which in turn mediates anchorage of the E-cadherin complex to the cortical actin cytoskeleton. Studies show that Beta-catenin also binds to another cytoskeletal complex containing the adenomatous polyposis coli protein and microtubules, and interacts with several signaling pathways that include tyrosine kinases, phosphatases and Wnt/Wingless. The interplay between beta-catenin, cytoskeletal complexes and signaling pathways may regulate morphogenesis. Beta-catenin is expressed in several hair follicle cell types, basal and peripheral matrix cells, and cells of the outer and inner root sheats. A pathological role of beta-catenin has been identified in pilomatrixoma (PTR), medulloblastoma (MDB), colorectal cancer (CRC), ovarian cancer, and tumor development. In the nucleus, beta-catenin serves to co activate a family of Lef/Tcf transcription factors that stimulate transcription of target genes including those encoding cyclin D and c-myc that promote cell proliferation. The influence on cell proliferation is the molecular basis for the role of beta-catenin in tumorgenesis, specifically, solid tumors of the breast, colon, liver, lung, gastric, prostate, and skin.

Immunogen :

Recombinant beta Catenin protein.

Format :

Liquid

Applications w/Dilutions :

Gel Shift: Assay-dependent, Immunocytochemistry: 1:50-1:1,000, Immunohistochemistry (Paraffin): 1:100-1:1,000, Immunoprecipitation: Assay-dependent, Western Blot: 1:500-1:1,000

Aliases :

armadillo; armadillo homolog; Bcatenin; b-catenin; beta 1 88kDa; beta catenin; Betacatenin; beta-catenin; beta-catenin 1; Bfc; C20orf33; Cadherin associated protein; catenin; catenin (cadherin associated protein), beta 1; catenin (cadherin associated protein), beta 1, 88kDa; catenin (cadherin-associated protein) beta 1; catenin (cadherin-associated protein), beta 1; catenin (cadherin-associated protein), beta 1, 88kDa; Catenin b 1; Catenin b1; catenin beta; catenin beta 1; catenin beta 1 L homeolog; Catenin beta1; Catenin beta-1; Catenin ß 1; Catenin ß1; Catnb; CHBCAT; CTNB1; CTNNB; ctnnb1; ctnnb1.L; ctnnb1-a; ctnnb1-b; dJ633O20.1; DKFZp686D02253; FLJ25606; FLJ37923; id:ibd2058; Mesc; MRD19; NAP; NYD-SP19; OK/SW-cl.35; OTTHUMP00000209289; P14L; PP8304; PRO2286; RP5-1118M15.1; wu:fb73e10; wu:fi81c06; wu:fk25h01; XELAEV_18031149mg; ß catenin; ßcatenin

more info or order :

Invitrogen product webpage