Plasma Kallikrein Monoclonal Antibody (13G11) | Invitrogen MA1-26321 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Plasma Kallikrein Monoclonal Antibody (13G11)

catalog :

MA1-26321

quantity :

50 ug

price :

US 480.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

13G11

The same clone is also sold as:

Abcam: ab1006

reactivity :

human

application :

western blot, ELISA

citations: 1

Reference
Popescu N, Silasi R, Keshari R, Girton A, Burgett T, Zeerleder S, et al. Peptidoglycan induces disseminated intravascular coagulation in baboons through activation of both coagulation pathways. Blood. 2018;: pubmed publisher

product information

Product Type :

Antibody

Product Name :

Plasma Kallikrein Monoclonal Antibody (13G11)

Catalog # :

MA1-26321

Quantity :

50 ug

Price :

US 480.00

Clonality :

Monoclonal

Purity :

Protein G

Host :

Mouse

Reactivity :

Human

Applications :

ELISA: 5-10 ug/mL, Western Blot: 1-5 ug/mL

Species :

Human

Clone :

13G11

Isotype :

IgG1

Storage :

Store at 4 C short term. For long term storage, store at -20 C, avoiding freeze/thaw cycles.

Description :

Plasma prekallikrein is a glycoprotein that participates in the surface-dependent activation of blood coagulation, fibrinolysis, kinin generation and inflammation. It is synthesized in the liver and secreted into the blood as a single polypeptide chain. Plasma prekallikrein is converted to plasma kallikrein by factor XIIa by the cleavage of an internal Arg-Ile bond. Plasma kallikrein therefore is composed of a heavy chain and a light chain held together by a disulphide bond. The heavy chain originates from the amino-terminal end of the zymogen and contains 4 tandem repeats of 90 or 91 amino acids. Each repeat harbors a novel structure called the apple domain. The heavy chain is required for the surface-dependent pro-coagulant activity of plasma kallikrein. The light chain contains the active site or catalytic domain of the enzyme and is homologous to the trypsin family of serine proteases. Plasma prekallikrein deficiency causes a prolonged activated partial thromboplastin time in patients.

Immunogen :

Purified human prekallikrein.

Format :

Liquid

Applications w/Dilutions :

ELISA: 5-10 ug/mL, Western Blot: 1-5 ug/mL

Aliases :

antigen, prostate specific; APS; EC 3.4.21.34; Fletcher factor; Kal3; Kal-3; kallikrein; kallikrein 3, plasma; kallikrein B plasma; kallikrein B, plasma (Fletcher factor) 1; kallikrein B, plasma 1; kallikrein B1; Kalp1; KALP15; kininogenin; Klk3; KLKB1; Pk; PKK; PKKD; plasma kallikrein; Plasma kallikrein heavy chain; Plasma kallikrein light chain; Plasma prekallikrein; PPK; prekallikrein; PSA