HSC70 Monoclonal Antibody (1B5) | Invitrogen MA1-26078 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

HSC70 Monoclonal Antibody (1B5)

catalog :

MA1-26078

quantity :

100 ug

price :

US 524.00

clonality :

monoclonal

host :

rat

conjugate :

nonconjugated

clone name :

1B5

reactivity :

Chinese hamsters, guinea pig, human, mouse, rat, dogs, pigs , domestic sheep, domestic rabbit

application :

western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation

more info or order :

Invitrogen product webpage

citations: 5

Published Application/Species/Sample/Dilution	Reference
western blot; mouse	Sharma M, Burré J, Sudhof T. Proteasome inhibition alleviates SNARE-dependent neurodegeneration. Sci Transl Med. 2012;4:147ra113 pubmed publisher
immunoprecipitation; mouse western blot; mouse; 1:500	Sharma M, Burr J, S dhof T. CSP? promotes SNARE-complex assembly by chaperoning SNAP-25 during synaptic activity. Nat Cell Biol. 2011;13:30-9 pubmed publisher
	Adang L, Mowafy S, Herbst Z, Zhou Z, Schlotawa L, Radhakrishnan K, et al. Biochemical signatures of disease severity in multiple sulfatase deficiency. J Inherit Metab Dis. 2024;47:374-386 pubmed publisher
	Kowal J, Arras G, Colombo M, Jouve M, Morath J, Primdal Bengtson B, et al. Proteomic comparison defines novel markers to characterize heterogeneous populations of extracellular vesicle subtypes. Proc Natl Acad Sci U S A. 2016;113:E968-77 pubmed publisher
	Macri C, Wang F, Tasset I, Schall N, Page N, Briand J, et al. Modulation of deregulated chaperone-mediated autophagy by a phosphopeptide. Autophagy. 2015;11:472-86 pubmed publisher

product information

Product Type :

Antibody

Product Name :

HSC70 Monoclonal Antibody (1B5)

Catalog # :

MA1-26078

Quantity :

100 ug

Price :

US 524.00

Clonality :

Monoclonal

Purity :

Protein G

Host :

Rat

Reactivity :

Canine, Guinea Pig, Hamster, Human, Many, Mouse, Ovine, Porcine, Rabbit, Rat

Applications :

Immunocytochemistry: 1 ug/mL, Immunohistochemistry: Assay-dependent, Immunoprecipitation: 5 ug/mL, Western Blot: 0.5 ug/mL

Species :

Canine, Guinea Pig, Hamster, Human, Many, Mouse, Ovine, Porcine, Rabbit, Rat

Clone :

1B5

Isotype :

IgG2a

Storage :

Store at 4 C short term. For long term storage, store at -20 C, avoiding freeze/thaw cycles.

Description :

The HSP70 family is a set of highly conserved proteins that are induced by a variety of biological stresses, including heat stress, in every organism in which the proteins have been examined. The human HSP70 family members include: HSP70, a protein which is strongly inducible in all organisms but which is also constitutively expressed in primate cells; HSP72, a 72 kDa protein that is induced exclusively under stress conditions; HSC70, or cognate protein, is a 72 kDa, constitutively expressed, protein which is involved in the uncoating of clathrin coated vesicles; GRP78, or BiP, is a glucose regulated 78 kDa protein localized in the endoplasmic reticulum; and p75, or HSP75, a 75 kDa protein that is found within the mitochondria. HSC70 (also known as HSC71, HSC73, HSP73, p72, prp73) is expressed constitutively and is slightly heat-inducible. HSC70 binds to the exposed loop of clathrin light chains to promote uncoating and can also bind the cytoskeleton which may facilitate cytoskeletal rearrangements. HSC70 has been shown to stimulate lysosomal degradation of intracellular proteins and to retard both aggregation and folding of mitochondrial precursor proteins in vitro.

Immunogen :

Full length, native Hsc70 protein purified from sodium arsenite treated heat-resistant variants of Chinese hamster cells.

Format :

Liquid

Applications w/Dilutions :

Immunocytochemistry: 1 ug/mL, Immunohistochemistry: Assay-dependent, Immunoprecipitation: 5 ug/mL, Western Blot: 0.5 ug/mL

Aliases :

2410008N15Rik; AAG2; constitutive heat shock protein 70; constitutively expressed heat shock protein; epididymis luminal protein 33; epididymis secretory sperm binding protein Li 72p; FAM10A1; Heat shock 70 kDa protein 8; heat shock 70kd protein 10; heat shock 70kd protein 10 (HSC71); heat shock 70kD protein 8; heat shock 70kDa protein 8; heat shock cognate; heat shock cognate 70; heat shock cognate 71 kD protein; heat shock cognate 71 kDa protein; heat shock cognate 71 kDa protein-like protein; heat shock cognate 71-kd protein; heat shock cognate hsc73; heat shock cognate protein 54; Heat shock cognate protein 70; heat shock protein 70 cognate; heat shock protein 8; heat shock protein A8; heat shock protein cognate 70; heat shock protein family A (Hsp70) member 8; HEL-33; HEL-S-72p; HIP; HSC54; Hsc70; Hsc70 ATPase; HSC70 protein; Hsc71; Hsc73; HSP70; HSP71; HSP73; Hspa10; Hspa8; hspa8 protein; I79_022974; LAP; LAP1; LAP-1; lipopolysaccharide-associated protein 1; LPS-associated protein 1; MGC131511; MGC29929; NIP71; N-myristoyltransferase inhibitor protein 71; Protein FAM10A1; similar to 7O KDa heat shock cognate protein; SNC6; unnamed protein product; wu:fb01g06; wu:fi48b06

more info or order :

Invitrogen product webpage