This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
PRMT5 Monoclonal Antibody (PRMT5-21)
catalog :
MA1-25470
quantity :
50 uL
price :
US 524.00
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
PRMT5-21

The same clone is also sold as:
reactivity :
Chinese hamsters, human, mouse, rat, dogs, chicken, bovine
application :
western blot, ELISA
citations: 3
Reference
Zhou Z, Chen Z, Zhou Q, Meng S, Shi J, Mui S, et al. SMYD4 monomethylates PRMT5 and forms a positive feedback loop to promote hepatocellular carcinoma progression. Cancer Sci. 2024;115:1587-1601 pubmed publisher
Quillien A, Gilbert G, Boulet M, Ethuin S, Waltzer L, Vandel L. Prmt5 promotes vascular morphogenesis independently of its methyltransferase activity. PLoS Genet. 2021;17:e1009641 pubmed publisher
Shailesh H, Siveen K, SIF S. Protein arginine methyltransferase 5 (PRMT5) activates WNT/β-catenin signalling in breast cancer cells via epigenetic silencing of DKK1 and DKK3. J Cell Mol Med. 2021;25:1583-1600 pubmed publisher
product information
Product Type :
Antibody
Product Name :
PRMT5 Monoclonal Antibody (PRMT5-21)
Catalog # :
MA1-25470
Quantity :
50 uL
Price :
US 524.00
Clonality :
Monoclonal
Purity :
purified
Host :
Mouse
Reactivity :
Bovine, Canine, Chicken, Hamster, Human, Mouse, Non-human primate, Rat
Applications :
ChIP Assay: 2.5 ug/10^6 cells, ELISA: Assay-dependent, Western Blot: 2 ug/mL
Species :
Bovine, Canine, Chicken, Hamster, Human, Mouse, Non-human primate, Rat
Clone :
PRMT5-21
Isotype :
IgG2a
Storage :
Store at 4 C short term. For long term storage, store at -20 C, avoiding freeze/thaw cycles.
Description :
PRMT5 (protein arginine N-methyltransferase 5) is an arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA. PRMT5 specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 and Sm D3; such methylation is required for the assembly and biogenesis of snRNP core particles.
Immunogen :
Fusion of mouse myeloma cells and splenocytes from mice immunized with PRMT5 containing the C-terminal region of the Human PRMT5 (residues 315-637).
Format :
Liquid
Applications w/Dilutions :
ChIP Assay: 2.5 ug/10^6 cells, ELISA: Assay-dependent, Western Blot: 2 ug/mL
Aliases :
72 kDa ICln-binding protein; EC 2.1.1.125; histone-arginine N-methyltransferase PRMT5; HMT1 hnRNP methyltransferase-like 5; HRMT1L5; hypothetical protein; I79_013398; IBP72; Jak-binding protein 1; JBP1; PRMT5; protein arginine methyltransferase 5; protein arginine N-methyltransferase 5; Protein arginine N-methyltransferase 5, N-terminally processed; protein arginine N-methyltransferase 5-like; shk1 kinase-binding protein 1 homolog; Skb1; SKB1 homolog; SKB1Hs
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA