This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
Cdc27 Monoclonal Antibody (AF3.1)
catalog :
MA1-24749
quantity :
100 uL
price :
US 524.00
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
AF3.1

The same clone is also sold as:
reactivity :
human, mouse, rat, dogs, bovine, Xenopus laevis
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation, immunohistochemistry - paraffin section
citations: 2
Reference
Ferguson C, Urso O, Bodrug T, Gassaway B, Watson E, Prabu J, et al. APC7 mediates ubiquitin signaling in constitutive heterochromatin in the developing mammalian brain. Mol Cell. 2022;82:90-105.e13 pubmed publisher
Vassilopoulos A, Tominaga Y, Kim H, Lahusen T, Li B, Yu H, et al. WEE1 murine deficiency induces hyper-activation of APC/C and results in genomic instability and carcinogenesis. Oncogene. 2015;34:3023-35 pubmed publisher
product information
Product Type :
Antibody
Product Name :
Cdc27 Monoclonal Antibody (AF3.1)
Catalog # :
MA1-24749
Quantity :
100 uL
Price :
US 524.00
Clonality :
Monoclonal
Purity :
protein A
Host :
Mouse
Reactivity :
Bovine, Canine, Human, Mouse, Rat, Xenopus laevis
Applications :
ELISA: Assay-dependent, Immunocytochemistry: Assay-dependent, Immunohistochemistry (Paraffin): Assay-dependent, Immunoprecipitation: Assay-dependent, Western Blot: 1-2 ug/mL
Species :
Bovine, Canine, Human, Mouse, Rat, Xenopus laevis
Clone :
AF3.1
Isotype :
IgG2b
Storage :
Store at 4 C short term. For long term storage, store at -20 C, avoiding freeze/thaw cycles.
Description :
The protein encoded by this gene shares strong similarity with Saccharomyces cerevisiae protein Cdc27, and the gene product of Schizosaccharomyces pombe nuc 2. This protein is a component of anaphase-promoting complex (APC), which is composed of eight protein subunits and highly conserved in eukaryotic cells. APC catalyzes the formation of cyclin B-ubiquitin conjugate that is responsible for the ubiquitin-mediated proteolysis of B-type cyclins. This protein and 3 other members of the APC complex contain the TPR (tetratricopeptide repeat), a protein domain important for protein-protein interaction. This protein was shown to interact with mitotic checkpoint proteins including Mad2, p55CDC and BUBR1, and thus may be involved in controlling the timing of mitosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Immunogen :
Synthetic peptide, conjugated to KLH, corresponding to residues 814-823 of human Cdc27.
Format :
Liquid
Applications w/Dilutions :
ELISA: Assay-dependent, Immunocytochemistry: Assay-dependent, Immunohistochemistry (Paraffin): Assay-dependent, Immunoprecipitation: Assay-dependent, Western Blot: 1-2 ug/mL
Aliases :
AI452358; AN CDC27Hs; ANAPC3; anaphase promoting complex subunit 3; Anaphase-promoting complex subunit 3; anaphase-promoting complex, protein 3; APC3; BC023187; cdc27; CDC27 homolog; cdc27.S; CDC27Hs; cell division cycle 27; cell division cycle 27 homolog; cell division cycle 27 homolog (S. cerevisiae); cell division cycle 27 S homeolog; cell division cycle protein 27 homolog; D0S1430E; D17S978E; HNUC; H-NUC; hypothetical protein; NUC2; nuc2 homolog; XELAEV_18046079mg
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA