Caspase 12 Monoclonal Antibody (14F7) | Invitrogen MA1-24704 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Caspase 12 Monoclonal Antibody (14F7)

catalog :

MA1-24704

quantity :

50 uL

price :

US 474.00

clonality :

monoclonal

host :

rat

conjugate :

nonconjugated

clone name :

14F7

reactivity :

mouse, rat

application :

western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation

citations: 1

Reference
Xin J, Zhang Y, Li Y, Zhang L, Lin Y, Zheng L. Protective effects of Cervus nippon Temminck velvet antler polypeptides against MPP+?induced cytotoxicity in SH?SY5Y neuroblastoma cells. Mol Med Rep. 2017;16:5143-5150 pubmed publisher

product information

Product Type :

Antibody

Product Name :

Caspase 12 Monoclonal Antibody (14F7)

Catalog # :

MA1-24704

Quantity :

50 uL

Price :

US 474.00

Clonality :

Monoclonal

Purity :

purified

Host :

Rat

Reactivity :

Mouse, Rat

Applications :

Immunocytochemistry: Assay-dependent, Immunohistochemistry: Assay-dependent, Immunoprecipitation: Assay-dependent, Western Blot: 1-2 ug/mL

Species :

Mouse, Rat

Clone :

14F7

Isotype :

IgG2a

Storage :

Store at 4 C short term. For long term storage, store at -20 C, avoiding freeze/thaw cycles.

Description :

Three distinct signaling pathways lead to programmed cell death (apoptosis). The death receptor and mitochondrion pathways are the mains, in which the key apoptotic proteases capase-8 and caspase-9, respectively, are involved. The endoplasmic reticulum (ER) stress is the third apoptotic pathway and caspase-12 is involved. Caspase-12 is localized to the ER but not to cytoplasm or mitochondrion. Caspase-12 is activated by ER stress, including disruption of ER calcium homeostasis, and mediates ER stress-induced apoptosis. Caspase-12 is co-localized to the ER with several proteins that are involved in Alzheimer's disease including -gamma-secretase presenilin and beta-amyloid precursor protein (APP). Caspase-12 mediates cytotoxicity induced by amyloid-beta. Caspase-12 is ubiquitously expressed in mouse tissues.

Immunogen :

Recombinant fragment corresponding to residues 95-318 of mouse Caspase 12.

Format :

Liquid

Applications w/Dilutions :

Immunocytochemistry: Assay-dependent, Immunohistochemistry: Assay-dependent, Immunoprecipitation: Assay-dependent, Western Blot: 1-2 ug/mL

Aliases :

CASP12; CASP-12; CASP12P1; caspase 12; caspase 12 (gene/pseudogene); caspase 12 pseudogene 1; caspase-12; Inactive caspase-12; OTTMUSP00000045799; OTTMUSP00000045802; OTTMUSP00000045803; UNQ9415; UNQ9415/PRO34398