Tyrosine Hydroxylase Monoclonal Antibody (185) | Invitrogen MA1-24654 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Tyrosine Hydroxylase Monoclonal Antibody (185)

catalog :

MA1-24654

quantity :

50 µL

price :

US 496.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

185

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section

more info or order :

Invitrogen product webpage

citations: 11

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry; human; 1:400	Okoshi Y, Tanuma N, Miyata R, Hayashi M. Melatonin alterations and brain acetylcholine lesions in sleep disorders in Cockayne syndrome. Brain Dev. 2014;36:907-13 pubmed publisher
immunohistochemistry; human; 1:400	Okoshi Y, Hayashi M, Kanda S, Yamamoto T. An autopsy case of microencephaly, bizarre putaminal lesion, and cerebellar atrophy with heart and liver diseases. Brain Dev. 2014;36:707-10 pubmed publisher
immunohistochemistry; human; 1:400	Hayashi M, Nakajima K, Miyata R, Tanuma N, Kodama T. Lesions of acetylcholine neurons in refractory epilepsy. ISRN Neurol. 2012;2012:404263 pubmed publisher
immunohistochemistry; rat	Lundgren O, Jodal M, Jansson M, Ryberg A, Svensson L. Intestinal epithelial stem/progenitor cells are controlled by mucosal afferent nerves. PLoS ONE. 2011;6:e16295 pubmed publisher
immunohistochemistry; human; 1:400	Hayashi M, Hachiya Y, Arai N. An autopsy case presenting repetitive hypoglycemia and unique cortical dysplasia. Brain Dev. 2010;32:289-92 pubmed publisher
	Georgelou K, Saridaki E, Karali K, Papagiannaki A, Charalampopoulos I, Gravanis A, et al. Microneurotrophin BNN27 Reduces Astrogliosis and Increases Density of Neurons and Implanted Neural Stem Cell-Derived Cells after Spinal Cord Injury. Biomedicines. 2023;11: pubmed publisher
	Garcia DuBar S, Cosio D, Korthas H, Van Batavia J, Zderic S, Sahibzada N, et al. Somatostatin Neurons in the Mouse Pontine Nucleus Activate GABAA Receptor Mediated Synaptic Currents in Locus Coeruleus Neurons. Front Synaptic Neurosci. 2021;13:754786 pubmed publisher
	Cui K, Yang F, Tufan T, Raza M, Zhan Y, Fan Y, et al. Restoration of Noradrenergic Function in Parkinson's Disease Model Mice. ASN Neuro. 2021;13:17590914211009730 pubmed publisher
	Keck S, Galati Fournier V, Kym U, Moesch M, Usemann J, Muller I, et al. Lack of Mucosal Cholinergic Innervation Is Associated With Increased Risk of Enterocolitis in Hirschsprung's Disease. Cell Mol Gastroenterol Hepatol. 2021;12:507-545 pubmed publisher
	KEARNEY M, Warren T, Hisey E, Qi J, Mooney R. Discrete Evaluative and Premotor Circuits Enable Vocal Learning in Songbirds. Neuron. 2019;104:559-575.e6 pubmed publisher
	Zhou Q, Song Y, Huang C, Huang J, Gong Z, Liao Z, et al. Membrane Trafficking Protein CDP138 Regulates Fat Browning and Insulin Sensitivity through Controlling Catecholamine Release. Mol Cell Biol. 2018;38: pubmed publisher

product information

Product Type :

Antibody

Product Name :

Tyrosine Hydroxylase Monoclonal Antibody (185)

Catalog # :

MA1-24654

Quantity :

50 µL

Price :

US 496.00

Clonality :

Monoclonal

Host :

Mouse

Reactivity :

Human, Mouse, Rat

Applications :

Immunocytochemistry: 1:50, Immunohistochemistry (Frozen): Assay-dependent, Immunohistochemistry (Paraffin): Assay-dependent, Western Blot: 1:25-1:50

Species :

Human, Mouse, Rat

Clone :

185

Isotype :

IgG2a

Storage :

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Description :

Tyrosine hydroxylase (TH) is an enzyme involved in the synthesis of catecholamine neurotransmitters dopamine, epinephrine, and norepinephrine. In all species, catecholamine synthesis is regulated by the interaction of TH with a cofactor, tetrahydrobiopterin (BH4). BH4 binds to the TH catalytic domain, resulting in enzymatic activity. Unlike TH in non-primate species, four human TH mRNA splice variants (hTH1-hTH4) have been isolated. These variants are identical in their catalytic domain, but differ in their N-terminal, regulatory domains. TH is also responsible for the conversion of L-tyrosine to L-dopa. TH plays a key role in the physiology of adrenergic neurons. The role of TH in the synthesis of catecholamine neurotransmitters suggests a correlation between the enzyme and a number of neuropathogenic diseases including: Parkinson's disease, schizophrenia, Segawa syndrome, and dystonia, as well as a variety of cardiovascular diseases.

Immunogen :

Recombinant protein corresponding to the C-terminal portion of mouse Tyrosine Hydroxylase.

Format :

Liquid

Applications w/Dilutions :

Immunocytochemistry: 1:50, Immunohistochemistry (Frozen): Assay-dependent, Immunohistochemistry (Paraffin): Assay-dependent, Western Blot: 1:25-1:50

Aliases :

dystonia 14; DYT14; DYT5b; EC 1.14.16.2; HGNC:11782; Th; TH isoform 3; TH isoform a; th1; TH-4; The; TY3H; TYH; TYH antibody; Tyrosine 3-hydroxylase; tyrosine 3-monooxygenase; tyrosine hydroxylase

more info or order :

Invitrogen product webpage