ID3 Monoclonal Antibody (2B11) | Invitrogen MA1-23242 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

ID3 Monoclonal Antibody (2B11)

catalog :

MA1-23242

quantity :

100 uL

price :

US 480.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

2B11

The same clone is also sold as:

Novus Biologicals: NB500-112
Santa Cruz Biotechnology: sc-56712, sc-56712 AC, sc-56712 HRP

reactivity :

human, mouse

application :

western blot, immunocytochemistry, immunoprecipitation

citations: 1

Reference
Teo Z, Chan J, Chong H, Sng M, Choo C, Phua G, et al. Angiopoietin-like 4 induces a β-catenin-mediated upregulation of ID3 in fibroblasts to reduce scar collagen expression. Sci Rep. 2017;7:6303 pubmed publisher

product information

Product Type :

Antibody

Product Name :

ID3 Monoclonal Antibody (2B11)

Catalog # :

MA1-23242

Quantity :

100 uL

Price :

US 480.00

Clonality :

Monoclonal

Purity :

Protein G

Host :

Mouse

Reactivity :

Human, Mouse

Applications :

Immunocytochemistry: 1:100-1:1,000, Immunoprecipitation: 1-5 ug/mL, Western Blot: 1-5 ug/mL

Species :

Human, Mouse

Clone :

2B11

Isotype :

IgG1

Storage :

Store at 4 C short term. For long term storage, store at -20 C, avoiding freeze/thaw cycles.

Description :

Members of the Id family of basic helix-loop-helix (bHLH) proteins include ID1, ID2, ID3 and ID4. They are ubiquitously expressed and dimerize with members of the class A and B HLH proteins. Due to the absence of the basic region, the resulting heterodimers cannot bind DNA. The ID-type proteins thus appear to negatively regulate DNA binding of bHLH proteins. Since ID1 inhibits DNA binding of E12 and Myo D, it apparently functions to inhibit muscle-specific gene expression. Under conditions that facilitate muscle cell differentiation, the ID protein levels fall, allowing E12 and/or E47 to form heterodimers with Myo D and myogenin, which in turn activate myogenic differentiation. It has been shown that expression of each of the ID proteins is strongly dependent on growth factor activation and that reduction of ID mRNA levels by antisense oligonucleotides leads to a delayed reentry of arrested cells into the cell cycle following growth factor stimulation.

Immunogen :

The full-length (amino acids 1-119) mouse Id3 gene expressed in E. coli.

Format :

Liquid

Applications w/Dilutions :

Immunocytochemistry: 1:100-1:1,000, Immunoprecipitation: 1-5 ug/mL, Western Blot: 1-5 ug/mL

Aliases :

1R21; bHLHb25; class B basic helix-loop-helix protein 25; DNA-binding protein inhibitor ID-3; HEIR 1; HEIR1; HEIR-1; Helix-loop-helix protein HEIR-1; Hlh462; HLH642; ID 3; Id3; Id-3; Idb3; ID-like protein inhibitor HLH 1R21; ID-like protein inhibitor HLH 462; Inhibitor of differentiation 3; inhibitor of DNA binding 3; inhibitor of DNA binding 3, dominant negative helix-loop-helix protein; inhibitor of DNA binding 3, HLH protein