Integrin alpha-5 + Integrin beta-3 Monoclonal Antibody (23C6) | Invitrogen MA1-23050 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Integrin alpha-5 + Integrin beta-3 Monoclonal Antibody (23C6)

catalog :

MA1-23050

quantity :

100 µg

price :

US 475

clonality :

monoclonal

host :

mouse

clone name :

23C6

reactivity :

human

application :

immunohistochemistry, immunocytochemistry, flow cytometry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section, blocking or activating experiments

citations: 3

Published Application/Species/Dilution	Reference
neutralization; human	Bermudez L, Sangari F, Kolonoski P, Petrofsky M, Goodman J. The efficiency of the translocation of Mycobacterium tuberculosis across a bilayer of epithelial and endothelial cells as a model of the alveolar wall is a consequence of transport within mononuclear phagocytes and invasion of alveolar epithelial cells. Infect Immun. 2002;70:140-6 pubmed
immunocytochemistry; human	Kotake S, Yago T, Kawamoto M, Nanke Y. Voltage-dependent anion channels (VDACs, porin) expressed in the plasma membrane regulate the differentiation and function of human osteoclasts. Cell Biol Int. 2013;37:65-77 pubmed publisher
	Kotake S, Nanke Y, Kawamoto M, Yago T, Udagawa N, Ichikawa N, et al. T-cell leukemia translocation-associated gene (TCTA) protein is required for human osteoclastogenesis. Bone. 2009;45:627-39 pubmed publisher

product information

Product Type :

MA1-23050

Product Name :

Integrin alpha-5 + Integrin beta-3 Monoclonal Antibody (23C6)

Catalog # :

MA1-23050

Quantity :

100 µg

Price :

US 475

Clonality :

Monoclonal

Purity :

purified

Host :

Mouse

Reactivity :

Human

Applications :

ChIP assay, Flow Cytometry, Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin, Frozen), Immunoprecipitation and Neutralization

Species :

Clone :

23C6

Gene Identification :

Entrez: 3690, 3678; Uniprot: P05106, P08648

Isotype :

IgG1

Storage :

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Description :

Integrins are heterodimeric cell surface receptors composed of alpha and beta subunits, which mediate cell-cell and cell-extracellular matrix attachments. Aberrant integrin expression has been found in many epithelial tumours. Changes in integrin expression have been shown to be important for the growth and early metastatic capacity of melanoma cells. Integrin alpha V beta 3 is the predominant integrin of osteoclasts (bone resorbing cells) and is upregulated in malignant melanoma. Integrin alpha V beta 3 binds to a range of ECM proteins (e.g. vitronectin, fibrinogen, fibronectin) via an Arg-Gly-Asp (RGD) motif.

Immunogen :

Cell suspension containing osteoclasts from osteoclastomas.

Format :

Liquid; PBS with no preservative

Applications w/Dilutions :

FACS Assay dependent, IP Assay dependent, IHC (P, F) Assay dependent, Neu Assay dependent, ChIP Assay-dependent, ICC Assay-dependent, IF Assay-dependent

Aliases :

BDPLT2, CD61, GP3A, GPIIIa, GT, integrin beta-3, platelet glycoprotein IIIa, platelet membrane glycoprotein IIIa, ITGB3, Integrin alpha-5, CD49 antigen-like family member E, Fibronectin receptor subunit alpha, Integrin alpha-F, VLA-5, CD49e, Integrin alpha-5 heavy chain, Integrin alpha-5 light chain, ITGA5, FNRA

PubMed References :

19560569