Cardiac Troponin I Monoclonal Antibody (19C7) | Invitrogen MA1-22700 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Cardiac Troponin I Monoclonal Antibody (19C7)

catalog :

MA1-22700

quantity :

200 ug

price :

US 524.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

19C7

The same clone is also sold as:

Abcam: ab92408

reactivity :

domestic goat, human, mouse, rat, dogs, bovine, pigs , cat

application :

western blot, ELISA, immunohistochemistry, immunoprecipitation

citations: 6

Reference
Huang Y, Li L, Chen H, Liao Q, Yang X, Yang D, et al. The Protective Role of Yin-Yang 1 in Cardiac Injury and Remodeling After Myocardial Infarction. J Am Heart Assoc. 2021;10:e021895 pubmed publisher
Najafi A, van de Locht M, Schuldt M, Schönleitner P, van Willigenburg M, Bollen I, et al. End-diastolic force pre-activates cardiomyocytes and determines contractile force: role of titin and calcium. J Physiol. 2019;597:4521-4531 pubmed publisher
Verkaik M, Oranje M, Abdurrachim D, Goebel M, Gam Z, Prompers J, et al. High Fibroblast Growth Factor 23 concentrations in experimental renal failure impair calcium handling in cardiomyocytes. Physiol Rep. 2018;6:e13591 pubmed publisher
Bollen I, van der Meulen M, de Goede K, Kuster D, Dalinghaus M, van der Velden J. Cardiomyocyte Hypocontractility and Reduced Myofibril Density in End-Stage Pediatric Cardiomyopathy. Front Physiol. 2017;8:1103 pubmed publisher
Bollen I, Ehler E, Fleischanderl K, Bouwman F, Kempers L, Ricke Hoch M, et al. Myofilament Remodeling and Function Is More Impaired in Peripartum Cardiomyopathy Compared with Dilated Cardiomyopathy and Ischemic Heart Disease. Am J Pathol. 2017;187:2645-2658 pubmed publisher
Bollen I, Schuldt M, Harakalová M, Vink A, Asselbergs F, Pinto J, et al. Genotype-specific pathogenic effects in human dilated cardiomyopathy. J Physiol. 2017;595:4677-4693 pubmed publisher

product information

Product Type :

Antibody

Product Name :

Cardiac Troponin I Monoclonal Antibody (19C7)

Catalog # :

MA1-22700

Quantity :

200 ug

Price :

US 524.00

Clonality :

Monoclonal

Purity :

protein A

Host :

Mouse

Reactivity :

Bovine, Canine, Feline, Fish, Goat, Human, Mouse, Porcine, Rabbit, Rat

Applications :

Affinity Purification: Assay-dependent, ELISA: Assay-dependent, Immunohistochemistry: Assay-dependent, Immunoprecipitation: Assay-dependent, Western Blot: 1:500

Species :

Bovine, Canine, Feline, Fish, Goat, Human, Mouse, Porcine, Rabbit, Rat

Clone :

19C7

Isotype :

IgG2b

Storage :

4 C, do not freeze

Description :

Cardiac Troponin I (Cardiac-specific troponin I, TnI, Troponin I) is an integral inhibitory protein in cardiac muscle that exists as part of a complex with troponin C (TnC) and troponin T (TnT). The TnT subunit of troponin binds to tropomyosin-t form, a troponin-tropomyosin complex, anchored in place by the binding of TnI to actin, within muscle thin filaments. Structural change resulting from the binding of calcium to specific sites on the regulatory TnC subunit, releases the inhibitory region of TnI from actin, anabling the attachment of the molecular motor protein myosin, allowing for muscle contraction and hence movement. The measurements of blood TnI and TnT levels is an important diagnostics indicator of heart muscle damage, and can be used to differentiate between angina and myocardial infarction in patients with chest pains. Cardiac Troponin I has also been shown to inhibit angiogenesis in vivo and in vitro. Mutations in the Cardiac Troponin I gene cause familial hypertrophic cardiomyopathy type 7 (CMH7) and familial restrictive cardiomyopathy (RCM).

Immunogen :

Native troponin complex

Format :

Liquid

Applications w/Dilutions :

Affinity Purification: Assay-dependent, ELISA: Assay-dependent, Immunohistochemistry: Assay-dependent, Immunoprecipitation: Assay-dependent, Western Blot: 1:500

Aliases :

alternatively spliced; cardiac ankyrin repeat kinase; Cardiac muscle troponin T; cardiac troponin I; cardiac troponin I isoform; cardiac troponin I-interacting kinase; cardiac troponin T; cardiac troponin T isoform 1; cardiac troponin T isoform 2; cardiac troponin T2; cardiomyopathy, dilated 1D (autosomal dominant); cardiomyopathy, dilated 2A (autosomal recessive); cardiomyopathy, hypertrophic 2; CARK; CCDD; CMD1D; CMD1FF; CMD2A; CMH2; CMH7; CMPD2; cTnI; cTnT; Ctt; CTTG; D830019J24Rik; LVNC6; MGC116817; RATCTTG; RCM1; RCM3; Serine/threonine-protein kinase TNNI3K; Tn1; TnI; TNNC1; Tnni3; TNNI3 interacting kinase; TNNI3-interacting kinase; TNNI3K; tnni3k {ECO:0000250; TNNT2; Tnnt3; TnTc; Tpn1; troponin 1, type 3; troponin I type 3 (cardiac); troponin I, cardiac 3; troponin I, cardiac muscle; troponin I, cardiac muscle-like; troponin I3, cardiac type; Troponin T cardiac; troponin T cardiac isoform; troponin T isoform 1; troponin T isoform 2; troponin T splicing mutant isoform 1; troponin T splicing mutant isoform 2; troponin T type 2 (cardiac); troponin T, cardiac muscle; troponin T2, cardiac; troponin T2, cardiac type; truncated cardiac troponin T; UniProtKB:Q59H18}