CD34 Monoclonal Antibody (MEC14.7) | Invitrogen MA1-22646 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

CD34 Monoclonal Antibody (MEC14.7)

catalog :

MA1-22646

quantity :

100 µg

price :

US 430

clonality :

monoclonal

host :

rat

conjugate :

nonconjugated

clone name :

MEC14.7

reactivity :

human, mouse, domestic rabbit

application :

western blot, ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section

more info or order :

Invitrogen product webpage

citations: 8

Published Application/Species/Sample/Dilution	Reference
flow cytometry; mouse; fig 2	Paz H, Lynch M, Bogue C, Gasson J. The homeobox gene Hhex regulates the earliest stages of definitive hematopoiesis. Blood. 2010;116:1254-62 pubmed publisher
flow cytometry; mouse	Peng J, Kitchen S, West R, Sigler R, Eisenmann K, Alberts A. Myeloproliferative defects following targeting of the Drf1 gene encoding the mammalian diaphanous related formin mDia1. Cancer Res. 2007;67:7565-71 pubmed
	Li Q, Zhao F, Li Z, Duan X, Cheng J, Zhang J, et al. Autologous Fractionated Adipose Tissue as a Natural Biomaterial and Novel One-Step Stem Cell Therapy for Repairing Articular Cartilage Defects. Front Cell Dev Biol. 2020;8:694 pubmed publisher
	Mehes E, Baráth M, Gulyás M, Bugyik E, Geiszt M, Szöor A, et al. Enhanced endothelial motility and multicellular sprouting is mediated by the scaffold protein TKS4. Sci Rep. 2019;9:14363 pubmed publisher
	Park H, Yu D, Sung M, Oh E, Kim M, Song J, et al. Molecular changes in solitary fibrous tumor progression. J Mol Med (Berl). 2019;97:1413-1425 pubmed publisher
	Caballero S, Kent D, Sengupta N, Li Calzi S, Shaw L, Beli E, et al. Bone Marrow-Derived Cell Recruitment to the Neurosensory Retina and Retinal Pigment Epithelial Cell Layer Following Subthreshold Retinal Phototherapy. Invest Ophthalmol Vis Sci. 2017;58:5164-5176 pubmed publisher
	Yue G, Xie S, Lee J, Kwok H, Gao S, Nian Y, et al. New potential beneficial effects of actein, a triterpene glycoside isolated from Cimicifuga species, in breast cancer treatment. Sci Rep. 2016;6:35263 pubmed publisher
	Leonhardt F, Grundmann S, Behe M, Bluhm F, Dumont R, Braun F, et al. Inflammatory neovascularization during graft-versus-host disease is regulated by ?v integrin and miR-100. Blood. 2013;121:3307-18 pubmed publisher

product information

Product Type :

Antibody

Product Name :

CD34 Monoclonal Antibody (MEC14.7)

Catalog # :

MA1-22646

Quantity :

100 µg

Pricing :

US 430

Clonality :

Monoclonal

Purity :

Protein G

Host :

Rat

Reactivity :

Human, Mouse, Rabbit

Applications :

ELISA: Assay-dependent, Flow Cytometry: 1:500, Immunocytochemistry: Assay-dependent, Immunohistochemistry (Frozen): 1:500, Immunohistochemistry (Paraffin): 1:500, Immunoprecipitation: Assay-dependent, Western Blot: 1:500

Species :

Human, Mouse, Rabbit

Clone :

MEC14.7

Isotype :

IgG2a

Storage :

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Description :

CD34 is a highly glycosylated monomeric with a molecular weight range of 111-115 kDa surface protein that is present on many stem cell populations. CD34 is a stem cell marker although its expression on human hematopoietic stem cells is reversible. CD34 may serve as a surface receptor that undergoes receptor-mediated endocytosis and regulates adhesion, differentiation and proliferation of hematopoietic stem cells and other progenitors. CD34 expression is likely to represent a specific state of hematopoietic development that may have altered adhering properties with expanding and differentiating capabilities in both in vitro and in vivo conditions. CD34 is possibly an adhesion molecule with a putative role for mediating the attachment of stem cells to the bone marrow extracellular matrix or directly to stromal cells. Further, CD34 could act as a scaffold for the attachment of lineage specific glycans, allowing stem cells to bind to lectins expressed by stromal cells or other marrow components. CD34 is thought to have a role in presenting carbohydrate ligands to selectins. The intracellular chain of the CD34 antigen is a site of phosphorylation by activated protein kinase C suggesting a putative role in signal transduction. Diseases associated with CD34 dysfunction include dermatofibrosarcoma and neurofibroma.

Immunogen :

Mouse CD34

Format :

Liquid

Applications w/Dilutions :

Aliases :

(E3-independent) E2 ubiquitin-conjugating enzyme R1; AU040960; CD34; CD34 antigen; CD34 molecule; CDC34; cell division cycle 34; cell division cycle 34 homolog; cluster designation 34; cluster of differentiation antigen 34; E2 ubiquitin-conjugating enzyme R1; E2-CDC34; hematopoietic progenitor cell antigen CD34; hematopoietic progenitor cell marker CD34; Mucosialin; RP11-328D5.2; sialomucin protein; type 1 transmembrane protein; UBC3; UBCH3; UBE2R1; ubiquitin carrier protein; ubiquitin conjugating enzyme E2 R1; ubiquitin-conjugating enzyme E2 R1; Ubiquitin-conjugating enzyme E2-32 kDa complementing; ubiquitin-conjugating enzyme E2-CDC34; Ubiquitin-protein ligase R1

more info or order :

Invitrogen product webpage