TGF beta-1 Monoclonal Antibody (TB21) | Invitrogen MA1-21595 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

TGF beta-1 Monoclonal Antibody (TB21)

catalog :

MA1-21595

quantity :

100 µg

price :

US 432

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

TB21

reactivity :

human, mouse, rat, bovine, domestic sheep, domestic rabbit

application :

western blot, immunohistochemistry, neutralization, flow cytometry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section, blocking or activating experiments

more info or order :

Invitrogen product webpage

citations: 4

Published Application/Species/Sample/Dilution	Reference
blocking or activating experiments; human	Beswick E, Pinchuk I, Earley R, Schmitt D, Reyes V. Role of gastric epithelial cell-derived transforming growth factor beta in reduced CD4+ T cell proliferation and development of regulatory T cells during Helicobacter pylori infection. Infect Immun. 2011;79:2737-45 pubmed publisher
blocking or activating experiments; human	Bourreau E, Ronet C, Couppie P, Sainte Marie D, Tacchini Cottier F, Launois P. IL-10 producing CD8+ T cells in human infection with Leishmania guyanensis. Microbes Infect. 2007;9:1034-41 pubmed
blocking or activating experiments; human	Kariminia A, Bourreau E, Pascalis H, Couppie P, Sainte Marie D, Tacchini Cottier F, et al. Transforming growth factor beta 1 production by CD4+ CD25+ regulatory T cells in peripheral blood mononuclear cells from healthy subjects stimulated with Leishmania guyanensis. Infect Immun. 2005;73:5908-14 pubmed
	Xia X, Zhang Z, Zhu C, Ni B, Wang S, Yang S, et al. Neutrophil extracellular traps promote metastasis in gastric cancer patients with postoperative abdominal infectious complications. Nat Commun. 2022;13:1017 pubmed publisher

product information

Product Type :

Antibody

Product Name :

TGF beta-1 Monoclonal Antibody (TB21)

Catalog # :

MA1-21595

Quantity :

100 µg

Pricing :

US 432

Clonality :

Monoclonal

Purity :

IgG fraction, Protein G

Host :

Mouse

Reactivity :

Bovine, Human, Mink, Mouse, Mustelid, Ovine, Rabbit, Rat

Applications :

Flow Cytometry: Assay-dependent, Immunohistochemistry (Frozen): 1:1,000, Immunohistochemistry (Paraffin): Assay-dependent, Neutralization: Assay-dependent, Western Blot: 5-20 ng/mL

Species :

Bovine, Human, Mink, Mouse, Mustelid, Ovine, Rabbit, Rat

Clone :

TB21

Isotype :

IgG1

Storage :

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Description :

TGF beta-1 (TGFB1, Transforming Growth Factor Beta 1) is a polypeptide member of the transforming growth factor beta superfamily of cytokines, found almost ubiquitously in tissues. Transforming growth factor (TGF)-b is stored in the extracellular matrix as a latent complex with its pro-domain. Activation of TGF beta-1 requires the binding of aV integrin to an RGD sequence in the prodomain and exertion of force on this domain, which is held in the extracellular matrix by latent TGF-b binding proteins. Latent forms are complexes of TGF beta-1, an amino-terminal portion of the TGF-beta precursor, designated TGF-LAP (TGF-latency associated peptide), and a specific binding protein, known as LTBP. TGF beta-1 helps regulates proliferation, differentiation, adhesion, migration in many cell types. Many cells have TGF beta receptors, and the protein positively and negatively regulates many other growth factors. TGF beta-1 is cleaved into a latency-associated peptide and a mature TGF beta-1 peptide, and is found in either a latent form composed of a TGFB1 homodimer, a LAP homodimer, and a latent TGFB1-binding protein, or in an active form composed of a TGF beta-1 homodimer. The mature peptide may also form heterodimers with other TGF beta family members. The gene for TGF beta-1 is frequently upregulated in tumor cells, and mutations in this gene result in Camurati-Engelmann disease and cystic fibrosis.

Immunogen :

TGF-beta 1 from human platelets

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: Assay-dependent, Immunohistochemistry (Frozen): 1:1,000, Immunohistochemistry (Paraffin): Assay-dependent, Neutralization: Assay-dependent, Western Blot: 5-20 ng/mL

Aliases :

CED; cytokine; DPD1; LAP; Latency-associated peptide; prepro-transforming growth factor beta-1; regulatory protein; TGF b; TGF b 1; TGF beta; tgf beta 1; tgf beta1; TGF beta-1; TGF beta-1 protein; TGF ß; TGF ß 1; TGF ß1; Tgfb; TGFB1; TGF-B1; Tgfb-1; TGFbeta; TGF-beta 1; TGF-beta 1 protein; TGFbeta1; TGF-beta1; TGF-beta-1; TGFß1; Transforming growth factor; transforming growth factor b1; transforming growth factor beta; transforming growth factor beta 1; transforming growth factor beta-1; Transforming growth factor beta-1 proprotein; transforming growth factor beta-1 proprotein; transforming growth factor beta-1; transforming growth factor ß1; transforming growth factor, beta 1; transforming growth factor, beta 1 (Camurati-Engelmann disease); transforming growth factor, beta-1; transforming growth factor-beta 1; transforming growth factor-beta I; transforming growth factor-beta-1; transforming growth factor-beta-1 precursor; unnamed protein product

more info or order :

Invitrogen product webpage