This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
Bassoon Monoclonal Antibody (SAP7F407)
catalog :
MA1-20689
quantity :
50 ug
price :
US 612.00
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
SAP7F407

The same clone is also sold as:
reactivity :
mouse, rat
application :
western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation
citations: 4
Reference
Chen K, Hu Q, Gupta R, Stephens J, Xie Z, Yang G. Inhibition of unfolded protein response prevents post-anesthesia neuronal hyperactivity and synapse loss in aged mice. Aging Cell. 2022;21:e13592 pubmed publisher
Maddox J, Randall K, Yadav R, Williams B, Hagen J, Derr P, et al. A dual role for Cav1.4 Ca2+ channels in the molecular and structural organization of the rod photoreceptor synapse. elife. 2020;9: pubmed publisher
de Jong A, Roggero C, Ho M, Wong M, Brautigam C, Rizo J, et al. RIM C2B Domains Target Presynaptic Active Zone Functions to PIP2-Containing Membranes. Neuron. 2018;98:335-349.e7 pubmed publisher
Lee K, Chand K, Hammond L, Lavidis N, Noakes P. Functional decline at the aging neuromuscular junction is associated with altered laminin-α4 expression. Aging (Albany NY). 2017;9:880-899 pubmed publisher
product information
Product Type :
Antibody
Product Name :
Bassoon Monoclonal Antibody (SAP7F407)
Catalog # :
MA1-20689
Quantity :
50 ug
Price :
US 612.00
Clonality :
Monoclonal
Purity :
Protein G
Host :
Mouse
Reactivity :
Mouse, Rat
Applications :
Immunocytochemistry: Assay-dependent, Immunohistochemistry: 1:400, Immunoprecipitation: 2.5 ug, Western Blot: 1:500-1:1,000
Species :
Mouse, Rat
Clone :
SAP7F407
Isotype :
IgG2a
Storage :
Store at 4 C short term. For long term storage, store at -20 C, avoiding freeze/thaw cycles.
Description :
Bassoon is an approximately 420 kDa protein that is a localized at the presynaptic nerve terminals and is believed to play a role in the structural and functional organization of the synaptic vesicle cycle. Bassoon does not belong to any known protein families. It has been found in rat and mouse with sequence identity of the two proteins at 96%. The human BASSOON gene has recently been cloned and localized. Bassoon is predicted to contain two double-zinc fingers, three coiled-coil regions, and two polyglutamine domains. The polyglutamine domains in the C-terminus are of interest, since it is known that for some human proteins, such as Huntingtin, abnormal amplification of this region can cause late-onset neurodegeneration. Bassoon is concentrated at sites opposite to postsynaptic densities in synaptic terminals and in cultured neurons, it is found to colocalize with GABA (A) and glutamate (GluR1) receptors. Another presynaptic protein, Piccolo was found to colocalize with Bassoon in cultured hippocampal neurons. These observations suggested that they serve specific functions at synaptic junctions and may be involved in organization of the cytoskeleton at the site of neurotransmitter release.
Immunogen :
Recombinant, rat bassoon fragment (residues 738-1035) expressed as a fusion protein in E.coli.
Format :
Liquid
Applications w/Dilutions :
Immunocytochemistry: Assay-dependent, Immunohistochemistry: 1:400, Immunoprecipitation: 2.5 ug, Western Blot: 1:500-1:1,000
Aliases :
bassoon; bassoon (presynaptic cytomatrix protein); bassoon presynaptic cytomatrix protein; BSN; Kiaa0434; neuronal double zinc finger protein; presynaptic cytomatrix protein; protein bassoon; Zinc finger protein 231; ZNF231
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA