LAMP2 Monoclonal Antibody (H4B4) | Invitrogen MA1-205 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

LAMP2 Monoclonal Antibody (H4B4)

catalog :

MA1-205

quantity :

100 µg

price :

US 516.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

H4B4

reactivity :

human, mouse

application :

western blot, immunocytochemistry, flow cytometry

more info or order :

Invitrogen product webpage

citations: 7

Published Application/Species/Sample/Dilution	Reference
western blot; human; loading ...; fig 3a	Fonteneau J, Brilot F, MÃ¼nz C, GannagÃ© M. The Tumor Antigen NY-ESO-1 Mediates Direct Recognition of Melanoma Cells by CD4+ T Cells after Intercellular Antigen Transfer. J Immunol. 2016;196:64-71 pubmed publisher
	Bérard M, Sheta R, Malvaut S, Rodriguez Aller R, Teixeira M, Idi W, et al. A light-inducible protein clustering system for in vivo analysis of α-synuclein aggregation in Parkinson disease. PLoS Biol. 2022;20:e3001578 pubmed publisher
	Tsai S, Atai N, Cacciottolo M, Nice J, Salehi A, Guo C, et al. Exosome-mediated mRNA delivery in vivo is safe and can be used to induce SARS-CoV-2 immunity. J Biol Chem. 2021;297:101266 pubmed publisher
	Ressnerova A, Novotný F, Michalkova H, Pumera M, Adam V, Heger Z. Efficient Protein Transfection by Swarms of Chemically Powered Plasmonic Virus-Sized Nanorobots. ACS Nano. 2021;15:12899-12910 pubmed publisher
	Dykstra K, Fay H, Massey A, Yang N, Johnson M, Portwood S, et al. Inhibiting autophagy targets human leukemic stem cells and hypoxic AML blasts by disrupting mitochondrial homeostasis. Blood Adv. 2021;5:2087-2100 pubmed publisher
	Liu M, Pi H, Xi Y, Wang L, Tian L, Chen M, et al. KIF5A-dependent axonal transport deficiency disrupts autophagic flux in trimethyltin chloride-induced neurotoxicity. Autophagy. 2021;17:903-924 pubmed publisher
	Guo C, Tsai S, Ai Y, Li M, Pekosz A, Cox A, et al. The D614G Mutation Enhances the Lysosomal Trafficking of SARS-CoV-2 Spike. bioRxiv. 2020;: pubmed publisher

product information

Product Type :

Antibody

Product Name :

LAMP2 Monoclonal Antibody (H4B4)

Catalog # :

MA1-205

Quantity :

100 µg

Price :

US 516.00

Clonality :

Monoclonal

Purity :

protein A

Host :

Mouse

Reactivity :

Human, Mouse, Non-human primate

Applications :

Flow Cytometry: 5-10 µg/mL, Immunocytochemistry: 2-10 µg/mL, Western Blot: 1:1,000

Species :

Human, Mouse, Non-human primate

Clone :

H4B4

Isotype :

IgG2b

Storage :

-20°C

Description :

LAMP2 (Lysosome-associated membrane glycoprotein 2, CD107b) is a member of a family of membrane glycoproteins. LAMP2 provides selectins with carbohydrate ligands, and may play a role in tumor cell metastasis, and have a function in the protection, maintenance, and adhesion of the lysosome. Prior to posttranslational modification, LAMP2 is approximately 46 kDa polypeptide. Mature, functional LAMP2 is extensively glycosylated with a variety of different N-linked and O-linked oligosaccharides with a total molecular weight of about 100-130 kDa. LAMP 2 has a structure comprised of a large amino-terminal intra-lysosomal domain, a hydrophobic trans-membrane domain, and a short carboxyl-terminal cytoplasmic tail. LAMP2 is used to monitor a very selective form of autophagy called chaperone-mediated autophagy. LAMP 2 has a structure comprised of a large amino-terminal intra-lysosomal domain, a hydrophobic trans-membrane domain, and a short carboxyl-terminal cytoplasmic tail. The LAMP protein has 3 variant forms: LAMP-2A, -2B, and 2C. LAMP2, together with CD107a/LAMP-1, is a major constituent of lysosomal membrane. The LAMP proteins are involved in lysosome biogenesis and are required for fusion of lysosomes with phagosomes, and LAMP2 is an important regulator in successful phagosomal maturation. LAMP2 deficiency causes an accumulation of autophagosomes in many tissues leading to cardiomyopathy and myopathy (Danon’s disease).

Immunogen :

adherent spleen cells of human origin

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 5-10 µg/mL, Immunocytochemistry: 2-10 µg/mL, Western Blot: 1:1,000

Aliases :

CD107 antigen-like family member B; CD107b; EGK_20887; Igp96; Lamp II; LAMP2; LAMP-2; LAMP-2 Isoform 2A; LAMP-2 Variant A; Lamp-2a; Lamp-2b; Lamp-2c; LAMPB; LGP110; LGP-110; LGP-96; LGP-B; lysosomal associated membrane protein 2; lysosomal membrane glycoprotein 2; lysosomal membrane glycoprotein type B; lysosomal-associated membrane protein 2; lysosome-associated membrane glycoprotein 2; lysosome-associated membrane protein 2; Mac3; RP23-193O17.2

more info or order :

Invitrogen product webpage