TLR4 Monoclonal Antibody (HTA125), PE | Invitrogen MA1-20237 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

TLR4 Monoclonal Antibody (HTA125), PE

catalog :

MA1-20237

quantity :

50 Tests

price :

US 474.00

clonality :

monoclonal

host :

mouse

conjugate :

clone name :

HTA125

reactivity :

guinea pig, human, mouse, dogs, pigs , rhesus macaque

application :

immunocytochemistry, flow cytometry, blocking or activating experiments

more info or order :

Invitrogen product webpage

citations: 2

Published Application/Species/Sample/Dilution	Reference
flow cytometry; human	Bayram M, Soylu A, Ates H, Kizildag S, Kavukcu S. TLR-4 polymorphisms and leukocyte TLR-4 expression in febrile UTI and renal scarring. Pediatr Nephrol. 2013;28:1827-35 pubmed publisher
blocking or activating experiments; mouse	Doi H, Iyer T, Carpenter E, Li H, Chang K, Vonderheide R, et al. Dysfunctional B-cell activation in cirrhosis resulting from hepatitis C infection associated with disappearance of CD27-positive B-cell population. Hepatology. 2012;55:709-19 pubmed publisher

product information

Product Type :

Antibody

Product Name :

TLR4 Monoclonal Antibody (HTA125), PE

Catalog # :

MA1-20237

Quantity :

50 Tests

Price :

US 474.00

Clonality :

Monoclonal

Purity :

Protein G

Host :

Mouse

Reactivity :

Canine, Guinea Pig, Human, Non-human primate, Porcine, Rhesus Monkey

Applications :

Flow Cytometry: Neat, Immunocytochemistry: Assay-dependent

Species :

Canine, Guinea Pig, Human, Non-human primate, Porcine, Rhesus Monkey

Clone :

HTA125

Isotype :

IgG2a

Storage :

4 C, store in dark, DO NOT FREEZE!

Description :

TLR4 is member of the Toll like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. This receptor is most abundantly expressed in placenta, and in myelomonocytic subpopulation of the leukocytes. Mammalian cells respond to LPS by activating TLR4. TLR4 belongs to the multi-protein complex of lipopolysaccharide (LPS) receptor, containing CD14, LY96 and TLR4, and is involved in signal transduction events induced by lipopolysaccharide (LPS) found in most gram-negative bacteria. TLR4 aids in the recognition of pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. Mutations in the TLR4 gene have been associated with differences in LPS responsiveness. Also, several transcript variants of the TLR4 gene have been found, but the protein coding potential of most of them is uncertain. TLR4 is expressed by peripheral blood monocytes and a small population of B-cells and is also expressed in human placenta. Studies with TLR4-deficient mice indicate that the main ligand for TLR is lipopolysaccharide. Consequently, these mice also showed increased susceptibility to Gram-negative sepsis.

Immunogen :

Human TLR4 expressed in Ba/F3 cell line.

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: Neat, Immunocytochemistry: Assay-dependent

Aliases :

ARMD10; CD284; EGK_07381; homolog of Drosophila toll; hToll; lipopolysaccharide response; Lps; Ly87; Ran/M1; Rasl2-8; Tlr4; TLR-4; TOLL; toll like receptor 4; toll/interleukin-l receptor (TIR) domain; toll4; toll-like receptor 4; toll-like receptor 4 immunity-related protein; Toll-like receptor 4-like protein; Toll-like receptor4 protein

more info or order :

Invitrogen product webpage