Acetylated Lysine Monoclonal Antibody (1C6) | Invitrogen MA1-2021 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Acetylated Lysine Monoclonal Antibody (1C6)

catalog :

MA1-2021

quantity :

100 ug

price :

US 491.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

1C6

application :

western blot, immunocytochemistry, immunoprecipitation, dot blot

citations: 10

Reference
Lancho O, Singh A, da Silva Diz V, Aleksandrova M, Khatun J, Tottone L, et al. A Therapeutically Targetable NOTCH1-SIRT1-KAT7 Axis in T-cell Leukemia. Blood Cancer Discov. 2023;4:12-33 pubmed publisher
Qiu Y, Yu Y, Qin X, Jiang T, Tan Y, Ouyang W, et al. CircTLK1 modulates sepsis-induced cardiomyocyte apoptosis via enhancing PARP1/HMGB1 axis-mediated mitochondrial DNA damage by sponging miR-17-5p. J Cell Mol Med. 2021;25:8244-8260 pubmed publisher
Nimmakayala R, Rauth S, Chirravuri Venkata R, Marimuthu S, Nallasamy P, Vengoji R, et al. PGC1α-Mediated Metabolic Reprogramming Drives the Stemness of Pancreatic Precursor Lesions. Clin Cancer Res. 2021;27:5415-5429 pubmed publisher
McIntyre J, Sobolewska A, Fedorowicz M, McLenigan M, Macias M, Woodgate R, et al. DNA polymerase ι is acetylated in response to SN2 alkylating agents. Sci Rep. 2019;9:4789 pubmed publisher
Yoon S, Kim J. Poly(ADP-ribose) polymerase 1 contributes to oxidative stress through downregulation of sirtuin 3 during cisplatin nephrotoxicity. Anat Cell Biol. 2016;49:165-176 pubmed
Cui W, Sun M, Zhang S, Shen X, Galeva N, Williams T, et al. A SUMO-acetyl switch in PXR biology. Biochim Biophys Acta. 2016;1859:1170-1182 pubmed publisher
Renaud E, Barascu A, Rosselli F. Impaired TIP60-mediated H4K16 acetylation accounts for the aberrant chromatin accumulation of 53BP1 and RAP80 in Fanconi anemia pathway-deficient cells. Nucleic Acids Res. 2016;44:648-56 pubmed publisher
Lee J, Kapur M, Li M, Choi M, Choi S, Kim H, et al. MFN1 deacetylation activates adaptive mitochondrial fusion and protects metabolically challenged mitochondria. J Cell Sci. 2014;127:4954-63 pubmed publisher
Koen Y, Sarma D, Hajovsky H, Galeva N, Williams T, Staudinger J, et al. Protein targets of thioacetamide metabolites in rat hepatocytes. Chem Res Toxicol. 2013;26:564-74 pubmed publisher
Kuo H, Lee D, Chen C, Liu M, Chou C, Lee H, et al. ARD1 stabilization of TSC2 suppresses tumorigenesis through the mTOR signaling pathway. Sci Signal. 2010;3:ra9 pubmed publisher

product information

Product Type :

Antibody

Product Name :

Acetylated Lysine Monoclonal Antibody (1C6)

Catalog # :

MA1-2021

Quantity :

100 ug

Price :

US 491.00

Clonality :

Monoclonal

Purity :

Protein G

Host :

Mouse

Reactivity :

Chemical

Applications :

ChIP Assay: 10 ug, Dot Blot: Assay-dependent, Immunocytochemistry: 1:100 - 1:500, Immunoprecipitation: 3 ug, Peptide array: Assay-dependent, Western Blot: 1:500-1:2,000

Species :

Chemical

Clone :

1C6

Isotype :

IgG2b

Storage :

-20 C, Avoid Freeze/Thaw Cycles

Description :

In the nucleus, DNA is tightly packed into nucleosomes generating an environment which is highly repressive towards DNA processes such as transcription. Acetylation of lysine residues within proteins has emerged as an important mechanism used by cells to overcome this repression. The acetylation of non-histone proteins such as transcription factors, as well as histones appears to be involved in this process. Acetylation may result in structural transitions as well as specific signaling within discrete chromatin domains. The role of acetylation in intracellular signaling has been inferred from the binding of acetylated peptides by the conserved bromodomain. Furthermore, recent findings suggest that bromodomain/acetylated-lysine recognition can serve as a regulatory mechanism in protein-protein interactions in numerous cellular processes such as chromatin remodeling and transcriptional activation.

Immunogen :

Synthetic peptide sequence surrounding the acetylated lysine 9 of histone H3.

Format :

Liquid

Applications w/Dilutions :

ChIP Assay: 10 ug, Dot Blot: Assay-dependent, Immunocytochemistry: 1:100 - 1:500, Immunoprecipitation: 3 ug, Peptide array: Assay-dependent, Western Blot: 1:500-1:2,000

Aliases :

Acetyl Lysine; Acetylated Lysine; Acetyllysine