Cardiac Troponin I Monoclonal Antibody (10B11) | Invitrogen MA1-20111 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Cardiac Troponin I Monoclonal Antibody (10B11)

catalog :

MA1-20111

quantity :

200µg

price :

330 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

10B11

reactivity :

human, rat, dog, pig, cat, rabbit

application :

western blot

product information

Product Type :

Antibody

Product Name :

Cardiac Troponin I Monoclonal Antibody (10B11)

Catalog # :

MA1-20111

Catalog # :

MA120111

Quantity :

200µg

Price :

330 USD

Clonality :

Monoclonal

Purity :

protein A

Host :

Mouse

Reactivity :

Canine, Feline, Human, Porcine, Rabbit, Rat

Applications :

Western Blot: Assay dependent

Species :

Canine, Feline, Human, Porcine, Rabbit, Rat

Clone :

10B11

Isotype :

IgG1

Storage :

4° C

Description :

Cardiac Troponin I (Cardiac-specific troponin I, TnI, Troponin I) is an integral inhibitory protein in cardiac muscle that exists as part of a complex with troponin C (TnC) and troponin T (TnT). The TnT subunit of troponin binds to tropomyosin-t form, a troponin-tropomyosin complex, anchored in place by the binding of TnI to actin, within muscle thin filaments. Structural change resulting from the binding of calcium to specific sites on the regulatory TnC subunit, releases the inhibitory region of TnI from actin, anabling the attachment of the molecular motor protein myosin, allowing for muscle contraction and hence movement. The measurements of blood TnI and TnT levels is an important diagnostics indicator of heart muscle damage, and can be used to differentiate between angina and myocardial infarction in patients with chest pains. Cardiac Troponin I has also been shown to inhibit angiogenesis in vivo and in vitro. Mutations in the Cardiac Troponin I gene cause familial hypertrophic cardiomyopathy type 7 (CMH7) and familial restrictive cardiomyopathy (RCM).

Immunogen :

Full length, human cardiac troponin 1 protein.

Format :

Liquid

Applications w/Dilutions :

Western Blot: Assay dependent

Aliases :

CMD2A, CMH7, MGC116817, RCM1, TNNC1, cTnI