Myeloperoxidase Monoclonal Antibody (2A11) | Invitrogen MA1-20073 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Myeloperoxidase Monoclonal Antibody (2A11)

catalog :

MA1-20073

quantity :

100 µg

price :

US 496

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

2A11

reactivity :

human

application :

immunocytochemistry

product information

Product Type :

Antibody

Product Name :

Myeloperoxidase Monoclonal Antibody (2A11)

Catalog # :

MA1-20073

Quantity :

100 µg

Price :

US 496

Clonality :

Monoclonal

Purity :

protein A

Host :

Mouse

Reactivity :

Human

Applications :

Affinity Purification: Assay Dependent, ELISA: Assay dependent, Immunocytochemistry: 1:200, Immunofluorescence: 1:200

Species :

Human

Clone :

2A11

Isotype :

IgG2a

Storage :

4° C, do not freeze

Description :

Myeloperoxidase (MPO) is a hemoprotein that is abundantly expressed in neutrophils and secreted during their activation. Native Myeloperoxidase is represented as a covalently bound tetrameric complex of two glycosylated alpha chains with a molecular weight range of 59 - 64 kDa, and two unglycosylated beta chains (MW ~14 kDa) with total MW ~150 kDa and a theoretical pI of 9.2. Traditionally, myeloperoxidase was considered as a main target of anti-neutrophil cytoplasm antibodies (ANCA), the serological markers for certain systemic vasculities such as periarteriitis nodosa, microscopic polyarteriitis and pulmonary eosinophilic granulomatosis (Churg-Strauss syndrome). Low to moderate anti-myeloperoxidase autoantibody levels are also reported in rheumatoid arthritis. Recently, it was shown that myeloperoxidase participates in the initiation and progression of cardiovascular disease. Myeloperoxidase possesses potent proinflammatory properties and may contribute directly to tissue injury. Now Myeloperoxidase is under consideration as one of the most promising cardiac markers. Myeloperoxidase is part of the host defense system of polymorphonuclear leukocytes and myeloperoxidase is responsible for microbicidal activity against a wide range of organisms. In the stimulated PMN (polymorphonuclear leukocytes), MPO catalyzes the production of hypohalous acids, primarily hypochlorous acid in physiologic situations, and other toxic intermediates that greatly enhance PMN microbicidal activity.

Immunogen :

Purified, full length, native, human myeloperoxidase protein.

Format :

Liquid

Applications w/Dilutions :

Affinity Purification: Assay Dependent, ELISA: Assay dependent, Immunocytochemistry: 1:200, Immunofluorescence: 1:200

Aliases :

84 kDa myeloperoxidase; 89 kDa myeloperoxidase; mKIAA4033; MPO; myeloperoxidase; Myeloperoxidase heavy chain; Myeloperoxidase light chain