P-cadherin Monoclonal Antibody (6A9) | Invitrogen MA1-2003 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

P-cadherin Monoclonal Antibody (6A9)

catalog :

MA1-2003

quantity :

100 ug

price :

US 486.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

6A9

reactivity :

human, mouse

application :

western blot, immunocytochemistry, immunoprecipitation

more info or order :

Invitrogen product webpage

citations: 8

Published Application/Species/Sample/Dilution	Reference
western blot; mouse; 1:5000; fig 7	Dianati E, Poiraud J, Weber Ouellette A, Plante I. Connexins, E-cadherin, Claudin-7 and ?-catenin transiently form junctional nexuses during the post-natal mammary gland development. Dev Biol. 2016;416:52-68 pubmed publisher
	Hwang P, Mathur J, Cao Y, Almeida J, Ye J, Morikis V, et al. A Cdh3-β-catenin-laminin signaling axis in a subset of breast tumor leader cells control leader cell polarization and directional collective migration. Dev Cell. 2023;58:34-50.e9 pubmed publisher
	Obr A, Bulatowicz J, Chang Y, Ciliento V, Lemenze A, Maingrette K, et al. Breast tumor IGF1R regulates cell adhesion and metastasis: alignment of mouse single cell and human breast cancer transcriptomics. Front Oncol. 2022;12:990398 pubmed publisher
	BazelliÃ¨res E, Conte V, Elosegui Artola A, Serra Picamal X, Bintanel Morcillo M, Roca Cusachs P, et al. Control of cell-cell forces and collective cell dynamics by the intercellular adhesome. Nat Cell Biol. 2015;17:409-20 pubmed publisher
	Hines M, Jin H, Wheelock M, Jensen P. Inhibition of cadherin function differentially affects markers of terminal differentiation in cultured human keratinocytes. J Cell Sci. 1999;112 ( Pt 24):4569-79 pubmed
	Nieman M, Kim J, Johnson K, Wheelock M. Mechanism of extracellular domain-deleted dominant negative cadherins. J Cell Sci. 1999;112 ( Pt 10):1621-32 pubmed
	Islam S, Carey T, Wolf G, Wheelock M, Johnson K. Expression of N-cadherin by human squamous carcinoma cells induces a scattered fibroblastic phenotype with disrupted cell-cell adhesion. J Cell Biol. 1996;135:1643-54 pubmed
	Wahl J, Sacco P, McGranahan Sadler T, Sauppé L, Wheelock M, Johnson K. Plakoglobin domains that define its association with the desmosomal cadherins and the classical cadherins: identification of unique and shared domains. J Cell Sci. 1996;109 ( Pt 5):1143-54 pubmed

product information

Product Type :

Antibody

Product Name :

P-cadherin Monoclonal Antibody (6A9)

Catalog # :

MA1-2003

Quantity :

100 ug

Price :

US 486.00

Clonality :

Monoclonal

Purity :

Protein G

Host :

Mouse

Reactivity :

Human, Mouse

Applications :

Immunocytochemistry: 10 ug/mL, Immunoprecipitation: Assay-dependent, Western Blot: 1:100-1:1,000

Species :

Human, Mouse

Clone :

6A9

Isotype :

IgG1

Storage :

-20 C, Avoid Freeze/Thaw Cycles

Description :

P-cadherin, also known as Cadherin-3, is a Type 1 cadherin protein that belongs to the cadherin superfamily. Type 1 cadherins are single-pass transmembrane proteins that have 5 extracellular cadherin repeats and an intracellular domain that binds p120-catenin and beta-catenin. Cadherins are calcium-dependent cell-cell adhesion glycoproteins responsible for a range of processes including development, wound healing, cell-cell signaling, cell growth and differentiation. P-cadherin is expressed in human fetal structures, and in adult tissues such as the basal layer of the epidermis, breast, prostate, ovary, cervix, hair follicle, and corneal endothelium. P-cadherin expression has also been reported on embryonic stem cells, and stem cells of the normal mammary gland, and hair follicle. Overexpression of P-cadherin has been associated with poor prognosis in breast, prostate, ovary, colon, and stomach carcinomas. Mutations in CDH3 are associated with congential hypotrichosis with juvenile macular dystrophy.

Immunogen :

A431 trypsinized membranes.

Format :

Liquid

Applications w/Dilutions :

Immunocytochemistry: 10 ug/mL, Immunoprecipitation: Assay-dependent, Western Blot: 1:100-1:1,000

Aliases :

AI385538; CADH3; cadherin 15, M-cadherin (myotubule); cadherin 3; cadherin 3, type 1, P-cadherin (placental); cadherin-3; Cadp; calcium-dependent adhesion protein, placental; CDH3; CDHP; HJMD; PCAD; P-cadherin; Placental cadherin; Placental-cadherin; RPE-specific cadherin

more info or order :

Invitrogen product webpage