DR4 Monoclonal Antibody (DR-4-02), FITC | Invitrogen MA1-19757 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

DR4 Monoclonal Antibody (DR-4-02), FITC

catalog :

MA1-19757

quantity :

100 ug

price :

US 442.00

clonality :

monoclonal

host :

mouse

conjugate :

FITC

clone name :

DR-4-02

The same clone is also sold as:

Novus Biologicals: NBP2-31343
Abcam: ab14738
Exbio: 1P-403-C100, 1F-403-C025, 1A-403-C025, 12-403-C100, 1P-403-C025, 1F-403-C100, 11-403-C025, 1A-403-C100, 11-403-C100
OriGene: SM3131LE, SM3131AC, SM3131F, SM3131R, SM3131PS

reactivity :

human

application :

flow cytometry

citations: 1

Reference
Greenlee J, Lopez Cavestany M, Ortiz Otero N, Liu K, Subramanian T, Cagir B, et al. Oxaliplatin resistance in colorectal cancer enhances TRAIL sensitivity via death receptor 4 upregulation and lipid raft localization. elife. 2021;10: pubmed publisher

product information

Product Type :

Antibody

Product Name :

DR4 Monoclonal Antibody (DR-4-02), FITC

Catalog # :

MA1-19757

Quantity :

100 ug

Price :

US 442.00

Clonality :

Monoclonal

Purity :

Size-exclusion chromatography

Host :

Mouse

Reactivity :

Human

Applications :

Flow Cytometry: 3-5 ug/mL

Species :

Human

Clone :

DR-4-02

Isotype :

IgG1

Storage :

4 C, store in dark, DO NOT FREEZE!

Description :

TRAIL-R1 (CD261, DR4) is a type I transmembrane protein, also called TRAIL receptor 1. The ligand for this DR4 death receptor has been identified and termed TRAIL, which is a member of the TNF family. DR4, as many other receptors (Fas, TNFR1, etc.), mediates apoptosis and NF kappaB activation in many cells and tissues. Apoptosis, a programmed cell death, is a operating process in normal cellular differentiation and development of multicellular organisms. Apoptosis is induced by coupled of certain cytokines (TNF family - TNF, Fas ligand) and their death domain containing receptors (TNFR1, Fas receptor).

Immunogen :

Fusion protein containing the extracellular part of TRAIL-R1 and the constant part of the heavy chain of the human IgG1.

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 3-5 ug/mL

Aliases :

APO2; CD261; cytotoxic TRAIL receptor; death receptor 4; DR4; MGC9365; sCD261; soluble CD261; soluble TRAIL; sTRAIL; TNF receptor superfamily member 10a; TNF-related apoptosis-inducing ligand receptor 1; TNFRSF10A; TRAIL R1; TRAIL receptor 1; TRAILR1; TRAIL-R1; TRAILR-1; tumor necrosis factor receptor superfamily member 10A; tumor necrosis factor receptor superfamily member 10a variant 2; tumor necrosis factor receptor superfamily, member 10a