CD63 Monoclonal Antibody (MEM-259), FITC | Invitrogen MA1-19602 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

CD63 Monoclonal Antibody (MEM-259), FITC

catalog :

MA1-19602

quantity :

100 Tests

price :

US 346.00

clonality :

monoclonal

host :

mouse

conjugate :

FITC

clone name :

MEM-259

reactivity :

human

application :

immunocytochemistry, flow cytometry

more info or order :

Invitrogen product webpage

citations: 3

Published Application/Species/Sample/Dilution	Reference
flow cytometry; human immunocytochemistry; human	Ng Y, Rome S, Jalabert A, Forterre A, Singh H, Hincks C, et al. Endometrial exosomes/microvesicles in the uterine microenvironment: a new paradigm for embryo-endometrial cross talk at implantation. PLoS ONE. 2013;8:e58502 pubmed publisher
	Malik S, Saltzman W, Bahal R. Extracellular vesicles mediated exocytosis of antisense peptide nucleic acids. Mol Ther Nucleic Acids. 2021;25:302-315 pubmed publisher
	Walker S, Selfors L, Margolis B, Brugge J. CRB3 and the FERM protein EPB41L4B regulate proliferation of mammary epithelial cells through the release of amphiregulin. PLoS ONE. 2018;13:e0207470 pubmed publisher

image

image 1 :

product information

Product Type :

Antibody

Product Name :

CD63 Monoclonal Antibody (MEM-259), FITC

Catalog # :

MA1-19602

Quantity :

100 Tests

Price :

US 346.00

Clonality :

Monoclonal

Purity :

Size-exclusion chromatography

Host :

Mouse

Reactivity :

Human

Applications :

Flow Cytometry: 20 µL x 100 µL whole blood or 10^6 cells, Immunocytochemistry: Assay-dependent

Species :

Human

Clone :

MEM-259

Isotype :

IgG1

Storage :

4° C, store in dark, DO NOT FREEZE!

Description :

CD63 (LAMP-3, lysosome-associated membrane protein-3), a glycoprotein of tetraspanin family, is present in late endosomes, lysosomes and secretory vesicles of various cell types. CD63 is also present in the plasma membrane, usually following cell activation. Hence, CD63 has become a widely used basophil activation marker. In mast cells, however, CD63 exposition does not need their activation. CD63 interacts with integrins and affects phagocytosis and cell migration, it is also involved in H/K-ATPase trafficking regulation of ROMK1 channels. CD63 also serves as a T-cell costimulation molecule. Expression of CD63 can be used for predicting the prognosis in earlier stages of carcinomas. CD63 is expressed on activated platelets, and is a lysosomal membrane glycoprotein that is translocated to plasma membrane after platelet activation. CD63 is also present in monocytes and macrophages and is weakly expressed on granulocytes, B, and T cells. CD63 is identical to the melanoma-associated antigen which is ME491 and to the platelet antigen PTLGP40. Diseases associated with CD63 dysfunction include melanoma and Hermansky-Pudlak Syndrome.

Immunogen :

T cell line HPB-ALL.

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 20 µL x 100 µL whole blood or 10^6 cells, Immunocytochemistry: Assay-dependent

Aliases :

C75951; CD 63; Cd63; CD63 antigen; CD63 antigen (melanoma 1 antigen); Cd63 molecule; CD63 protein; granulophysin; LAMP-3; Lysosomal-associated membrane protein 3; lysosome-associated membrane glycoprotein 3; mast cell antigen AD1; ME491; melanoma 1 antigen; melanoma-associated antigen ME491; melanoma-associated antigen MLA1; MLA1; Ocular melanoma-associated antigen; OMA81H; Tetraspanin-30; TSPAN30; tspan-30

more info or order :

Invitrogen product webpage