STIM1 Monoclonal Antibody (CDN3H4) | Invitrogen MA1-19451 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

STIM1 Monoclonal Antibody (CDN3H4)

catalog :

MA1-19451

quantity :

100 µg

price :

US 440

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

CDN3H4

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, immunohistochemistry - paraffin section

more info or order :

Invitrogen product webpage

citations: 6

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry; human; 1:200; loading ...; fig 5cb	Tammineni E, Kraeva N, Figueroa L, Manno C, Ibarra C, Klip A, et al. Intracellular calcium leak lowers glucose storage in human muscle, promoting hyperglycemia and diabetes. elife. 2020;9: pubmed publisher
immunohistochemistry - paraffin section; human; 1:300; fig 6	Sun J, Lu F, He H, Shen J, Messina J, Mathew R, et al. STIM1- and Orai1-mediated Ca(2+) oscillation orchestrates invadopodium formation and melanoma invasion. J Cell Biol. 2014;207:535-48 pubmed publisher
western blot; mouse	Li T, FINCH E, Graham V, Zhang Z, Ding J, Burch J, et al. STIM1-Ca(2+) signaling is required for the hypertrophic growth of skeletal muscle in mice. Mol Cell Biol. 2012;32:3009-17 pubmed publisher
western blot; human	Li H, Ding X, Lopez J, Takeshima H, Ma J, Allen P, et al. Impaired Orai1-mediated resting Ca2+ entry reduces the cytosolic [Ca2+] and sarcoplasmic reticulum Ca2+ loading in quiescent junctophilin 1 knock-out myotubes. J Biol Chem. 2010;285:39171-9 pubmed publisher
	Voros O, Panyi G, Hajdu P. Immune Synapse Residency of Orai1 Alters Ca2+ Response of T Cells. Int J Mol Sci. 2021;22: pubmed publisher
	Besprozvannaya M, Dickson E, Li H, Ginburg K, Bers D, Auwerx J, et al. GRAM domain proteins specialize functionally distinct ER-PM contact sites in human cells. elife. 2018;7: pubmed publisher

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product information

Product Type :

Antibody

Product Name :

STIM1 Monoclonal Antibody (CDN3H4)

Catalog # :

MA1-19451

Quantity :

100 µg

Price :

US 440

Clonality :

Monoclonal

Purity :

protein A

Host :

Mouse

Reactivity :

Human, Mouse, Rat

Applications :

Immunocytochemistry: Assay Dependent, Immunohistochemistry (Paraffin): 5 µg/mL, Immunoprecipitation: Assay Dependent, Western Blot: 1 µg/mL

Species :

Human, Mouse, Rat

Clone :

CDN3H4

Isotype :

IgG1

Storage :

4° C, do not freeze

Description :

STIM1 (stromal interacting molecule; also known as GOK) acts as a sensor of calcium depletion within the endoplasmic reticulum and transduces the signal to Orai1, the presumptive CRAC channel at the plasma membrane. Following decrease of luminal calcium concentration, STIM1 oligomerizes and induces Orai1 to enable entry of extracellular calcium into the cytoplasm. However, the precise mechanism of STIM1-Orai1 interaction has not been elucidated yet. Many questions also remain to be solved around STIM1 functional distribution. It turns out that STIM1 associates with growing ends of microtubules and is involved in endoplasmic reticulum tubule extension.

Immunogen :

Synthetic peptide corresponding to the C-terminal cytoplasmic part of STIM1

Format :

Liquid

Applications w/Dilutions :

Immunocytochemistry: Assay Dependent, Immunohistochemistry (Paraffin): 5 µg/mL, Immunoprecipitation: Assay Dependent, Western Blot: 1 µg/mL

Aliases :

D11S4896E; GOK; IMD10; RGD:1306831}; SIM; Stim1; stim1 {ECO:0000312; STIM1L; STRMK; Stromal interaction molecule 1; stromal interaction molecule 1 precursor; TAM; TAM1

more info or order :

Invitrogen product webpage