TRAIL-R2 (DR5) Monoclonal Antibody (DR5-01-1) | Invitrogen MA1-19416 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

TRAIL-R2 (DR5) Monoclonal Antibody (DR5-01-1)

catalog :

MA1-19416

quantity :

100 µg

price :

US 366

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

DR5-01-1

reactivity :

human

application :

immunocytochemistry, flow cytometry

more info or order :

Invitrogen product webpage

citations: 4

Published Application/Species/Sample/Dilution	Reference
immunocytochemistry; human; 15 ug/ml	Vondálová Blanárová O, Jelínková I, Szöor A, Skender B, Soucek K, Horváth V, et al. Cisplatin and a potent platinum(IV) complex-mediated enhancement of TRAIL-induced cancer cells killing is associated with modulation of upstream events in the extrinsic apoptotic pathway. Carcinogenesis. 2011;32:42-51 pubmed publisher
	Zhang B, van Roosmalen I, Reis C, Setroikromo R, Quax W. Death receptor 5 is activated by fucosylation in colon cancer cells. FEBS J. 2019;286:555-571 pubmed publisher
	Duru A, Sutlu T, Wallblom A, Uttervall K, Lund J, Stellan B, et al. Deletion of Chromosomal Region 8p21 Confers Resistance to Bortezomib and Is Associated with Upregulated Decoy TRAIL Receptor Expression in Patients with Multiple Myeloma. PLoS ONE. 2015;10:e0138248 pubmed publisher
	van Roosmalen I, Reis C, Setroikromo R, Yuvaraj S, Joseph J, Tepper P, et al. The ER stress inducer DMC enhances TRAIL-induced apoptosis in glioblastoma. Springerplus. 2014;3:495 pubmed publisher

product information

Product Type :

Antibody

Product Name :

TRAIL-R2 (DR5) Monoclonal Antibody (DR5-01-1)

Catalog # :

MA1-19416

Quantity :

100 µg

Price :

US 366

Clonality :

Monoclonal

Purity :

protein A

Host :

Mouse

Reactivity :

Human

Applications :

Flow Cytometry: 1-10 µg/mL

Species :

Human

Clone :

DR5-01-1

Isotype :

IgG1

Storage :

4° C, do not freeze

Description :

DR5 (Apo2, TRAIL-R2, TRICK2, KILLER) is a recently identified death domain containing receptor for TRAIL, which mediates TRAIL induced apoptosis. DR5 is a member of the TNF-receptor superfamily, and contains an intracellular death domain. DR5 can be activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL/APO-2L), and transduces an apoptosis signal. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by DR5. Two transcript variants encoding different isoforms of DR5 and one non-coding transcript have been found. Overexpression of DR5 induces apoptosis and activates NF-kappa-B. DR5 is expressed in a number of cell types, and to particularly high levels in lymphocytes and spleen. Diseases associated with DR5 dysfunction include squamous cell carcinoma, and diffuse infiltrative lymphocytosis syndrome.

Immunogen :

Recombinant fusion protein of human IgG heavy chain and extracellular domain of DR5.

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 1-10 µg/mL

Aliases :

apoptosis inducing protein TRICK2A/2B; apoptosis inducing receptor TRAIL-R2; CD262; cytotoxic TRAIL receptor-2; death domain containing receptor for TRAIL/Apo-2L; death receptor 5; DR5; dr-5; Fas-like protein; Killer; KILLER/DR5; KILLER/DR5 TRAIL death-inducing receptor; Ly98; MK; p53-regulated DNA damage-inducible cell death receptor(killer); sCD262; soluble CD262; TNF receptor superfamily member 10b; TNF-related apoptosis-inducing ligand receptor 2; TNFRSF10B; TRAIL receptor 2; TRAILR2; TRAIL-R2; TRICK2; TRICK2A; TRICK2B; TRICKB; tumor necrosis factor receptor superfamily member 10B; tumor necrosis factor receptor superfamily, member 10b; tumor necrosis factor receptor-like protein ZTNFR9; UNQ160/PRO186; ZTNFR9

more info or order :

Invitrogen product webpage