SOCS3 Monoclonal Antibody (SO1) | Invitrogen MA1-19373 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

SOCS3 Monoclonal Antibody (SO1)

catalog :

MA1-19373

quantity :

100 µg

price :

US 496

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

SO1

reactivity :

human, mouse

application :

western blot, immunohistochemistry, immunocytochemistry

more info or order :

Invitrogen product webpage

citations: 1

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry; mouse; loading ...; fig 1e	Xie L, Yin Y, Benowitz L. Chemokine CCL5 promotes robust optic nerve regeneration and mediates many of the effects of CNTF gene therapy. Proc Natl Acad Sci U S A. 2021;118: pubmed publisher

image

image 1 :

product information

Product Type :

Antibody

Product Name :

SOCS3 Monoclonal Antibody (SO1)

Catalog # :

MA1-19373

Quantity :

100 µg

Price :

US 496

Clonality :

Monoclonal

Purity :

purified

Host :

Mouse

Reactivity :

Human

Applications :

Immunocytochemistry: Assay Dependent, Western Blot: 1 µg/mL

Species :

Human

Clone :

SO1

Isotype :

IgG2b

Storage :

4° C, do not freeze

Description :

Accumulating evidence demonstrates that cytokine receptor signaling is negatively regulated by a family of Src homology 2 domain-containing adaptor molecules Termed SOCS (Suppressor of Cytokine Signaling). To date, there are eight members of SOCS family have been recognized, they are SOCS-1, 2, 3, 4, 5, 6, 7 and CIS. Structurally the SOCS proteins are composed of an N-terminal region of variable length and amino acid composition, a central SH2 domain, and a previously unrecognized C-terminal motif that we have called the SOCS box. The SOCS proteins appear to form part of a classical negative feed back loop that regulates cytokine signal transduction via a STAT-induced transcriptional mechanism. Transcription of each of the SOCS genes occurs rapidly in vitro and in vivo in response to cytokines, and once produced, the various members of the SOCS family appear to inhibit signaling in different ways.

Immunogen :

Full-length SOCS3 protein.

Format :

Liquid

Applications w/Dilutions :

Immunocytochemistry: Assay Dependent, Western Blot: 1 µg/mL

Aliases :

ATOD4; CIS3; CIS-3; Cish3; cytokine inducible SH2-containing protein 3; cytokine-inducible SH2 protein 3; E2a-Pbx1 target gene in fibroblasts 10; Ef10; EF-10; MGC71791; Protein EF-10; SOCS3; SOCS-3; Ssi3; SSI-3; STAT-induced STAT inhibitor 3; suppressor of cytokine signaling 3

more info or order :

Invitrogen product webpage