Placental Alkaline Phosphatase Monoclonal Antibody (H7E8) | Invitrogen MA1-19354 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Placental Alkaline Phosphatase Monoclonal Antibody (H7E8)

catalog :

MA1-19354

quantity :

100 µg

price :

US 389

clonality :

monoclonal

host :

mouse

conjugate :

clone name :

H7E8

reactivity :

Carolina sphinx, human

application :

western blot, ELISA, immunohistochemistry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section

more info or order :

Invitrogen product webpage

citations: 1

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry; Carolina sphinx; 1:200; loading ...; fig 7a	Ramaker J, Swanson T, Copenhaver P. Manduca Contactin Regulates Amyloid Precursor Protein-Dependent Neuronal Migration. J Neurosci. 2016;36:8757-75 pubmed publisher

product information

Product Type :

Antibody

Product Name :

Placental Alkaline Phosphatase Monoclonal Antibody (H7E8)

Catalog # :

MA1-19354

Quantity :

100 µg

Price :

US 389

Clonality :

Monoclonal

Purity :

protein A

Host :

Mouse

Reactivity :

Human

Applications :

ELISA: Assay Dependent, Immunohistochemistry (Frozen): Assay Dependent, Immunohistochemistry (Paraffin): 10 µg/mL, Western Blot: Assay Dependent

Species :

Human

Clone :

H7E8

Isotype :

IgG2a

Storage :

4° C, do not freeze

Description :

Placental Alkaline Phosphatase plays an important role in the regulation of specific inflammatory disease processes. There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney for this form of alkaline phosphatase have been well characterized. Placental Alkaline Phosphatase reacts with a membrane-bound isoenzyme (Regan and Nagao type) of Placental Alkaline Phosphatase (PLAP) occurring in the placenta during the 3rd trimester of gestation. Placental Alkaline Phosphatase is useful in the identification of testicular germ cell tumors. Unlike germ cell tumors, PLAP-positive somatic cell tumors uniformly express epithelial membrane antigen (EMA). A proposed function of Placental Alkaline Phosphatase is matrix mineralization; however, mice that lack a functional form of this enzyme show normal skeletal development. Placental Alkaline Phosphatase has been linked directly to hypophosphatasia, a disorder that is characterized by hypercalcemia and includes skeletal defects. The character of hypophosphatasia can vary, however, depending on the specific mutation since this determines age of onset and severity of symptoms.

Immunogen :

Purified placental alkaline phosphatase.

Format :

Liquid

Applications w/Dilutions :

ELISA: Assay Dependent, Immunohistochemistry (Frozen): Assay Dependent, Immunohistochemistry (Paraffin): 10 µg/mL, Western Blot: Assay Dependent

Aliases :

Alkaline phosphatase Regan isozyme; alkaline phosphatase, placental; alkaline phosphatase, placental type; alkaline phosphomonoesterase; ALP; ALPP; AP-TNAP; DOA1; FLJ11281; FLJ40094; FLJ61142; FLJ93059; glycerophosphatase; HOPS; MGC161443; MGC167935; P PLAP; PALP; PLA2P; PLAA; Placental alkaline phosphatase 1; PLAP; PLAP-1; Regan isozyme; TNAP; TNSALP

more info or order :

Invitrogen product webpage