Syk Monoclonal Antibody (SYK-01) | Invitrogen MA1-19332 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Syk Monoclonal Antibody (SYK-01)

catalog :

MA1-19332

quantity :

100 µg

price :

US 496

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

SYK-01

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, immunohistochemistry - paraffin section

more info or order :

Invitrogen product webpage

citations: 3

Published Application/Species/Sample/Dilution	Reference
immunoprecipitation; mouse; fig 5 western blot; mouse; 1:1000; fig 2	Pereira M, Tourlomousis P, Wright J, P Monie T, Bryant C. CARD9 negatively regulates NLRP3-induced IL-1? production on Salmonella infection of macrophages. Nat Commun. 2016;7:12874 pubmed publisher
	Jung E, Suh K, Han J, Kim H, Kang H, Choi W, et al. Amyloid-β activates NLRP3 inflammasomes by affecting microglial immunometabolism through the Syk-AMPK pathway. Aging Cell. 2022;21:e13623 pubmed publisher
	Hernandez A, Foster G, Soderberg S, Fernandez A, Reynolds M, Orser M, et al. An Allosteric Shift in CD11c Affinity Activates a Proatherogenic State in Arrested Intermediate Monocytes. J Immunol. 2020;205:2806-2820 pubmed publisher

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product information

Product Type :

Antibody

Product Name :

Syk Monoclonal Antibody (SYK-01)

Catalog # :

MA1-19332

Quantity :

100 µg

Price :

US 496

Clonality :

Monoclonal

Purity :

protein A

Host :

Mouse

Reactivity :

Human, Mouse, Rat

Applications :

Immunocytochemistry: 5 µg/mL, Immunofluorescence: 5 µg/mL, Immunohistochemistry (Paraffin): 5 µg/mL, Immunoprecipitation: Assay Dependent, Western Blot: 1 µg/mL

Species :

Human, Mouse, Rat

Clone :

SYK-01

Isotype :

IgG1

Storage :

4° C, do not freeze

Description :

Syk is a cytoplasmic protein tyrosine kinase that translocates to the plasma membrane upon B cell antigen receptor (BCR) or the high-affinity IgE receptor (FcepsilonRI) triggering, and phosphorylates downstream adaptor proteins, thereby providing docking sites for initiation of subsequent signaling pathways, such as calcium mobilization, cytoskeleton remodeling, or transcription of specific genes. Syk binds to the receptor assemblies through interactions of its pair of SH2 domains with ITAM motives of the receptor, which have been phosphorylated by Src-family kinases. These kinases also help to activate Syk by phosphorylation of its activation loop.

Immunogen :

Recombinant fragment (aa 5-360) of human Syk.

Format :

Liquid

Applications w/Dilutions :

Immunocytochemistry: 5 µg/mL, Immunofluorescence: 5 µg/mL, Immunohistochemistry (Paraffin): 5 µg/mL, Immunoprecipitation: Assay Dependent, Western Blot: 1 µg/mL

Aliases :

DKFZp313N1010; EC 2.7.10.2; FLJ25043; FLJ37489; HGNC:11205; kinase Syk; KSYK; p72Syk; p72-Syk; ptk72; SP1; spleen associated tyrosine kinase; spleen tyrosine kinase; Syk; syk signaling; Sykb; tyrosine-kinase syk; Tyrosine-protein kinase SYK

more info or order :

Invitrogen product webpage