CD38 Monoclonal Antibody (HIT2) | Invitrogen MA1-19316 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

CD38 Monoclonal Antibody (HIT2)

catalog :

MA1-19316

quantity :

100 µg

price :

US 410

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

reactivity :

human, mouse

application :

western blot, immunohistochemistry, flow cytometry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section

more info or order :

Invitrogen product webpage

citations: 29

Published Application/Species/Sample/Dilution	Reference
flow cytometry; mouse; fig 1e-h	Bohannon C, Ende Z, Cao W, Mboko W, Ranjan P, Kumar A, et al. Influenza Virus Infects and Depletes Activated Adaptive Immune Responders. Adv Sci (Weinh). 2021;8:e2100693 pubmed publisher
flow cytometry; human; fig 5b	Laurent E, Sieber A, Salzer B, Wachernig A, Seigner J, Lehner M, et al. Directed Evolution of Stabilized Monomeric CD19 for Monovalent CAR Interaction Studies and Monitoring of CAR-T Cell Patients. ACS Synth Biol. 2021;10:1184-1198 pubmed publisher
flow cytometry; human; loading ...; fig 1a	Dam E, Maier A, Hocking A, Carlin J, Buckner J. Increased Binding of Specificity Protein 1 to the IL21R Promoter in B Cells Results in Enhanced B Cell Responses in Rheumatoid Arthritis. Front Immunol. 2018;9:1978 pubmed publisher
flow cytometry; human; loading ...; fig 4a	Moysi E, Pallikkuth S, de Armas L, Gonzalez L, Ambrozak D, George V, et al. Altered immune cell follicular dynamics in HIV infection following influenza vaccination. J Clin Invest. 2018;128:3171-3185 pubmed publisher
flow cytometry; human; loading ...	Tauriainen J, Scharf L, Frederiksen J, Naji A, Ljunggren H, Sonnerborg A, et al. Perturbed CD8+ T cell TIGIT/CD226/PVR axis despite early initiation of antiretroviral treatment in HIV infected individuals. Sci Rep. 2017;7:40354 pubmed publisher
flow cytometry; human; loading ...; fig 1a	Zhen A, Rezek V, Youn C, Lam B, Chang N, Rick J, et al. Targeting type I interferon-mediated activation restores immune function in chronic HIV infection. J Clin Invest. 2017;127:260-268 pubmed publisher
flow cytometry; human; loading ...; fig 1a	Keefer M, Zheng B, Rosenberg A, Kobie J. Increased Steady-State Memory B Cell Subsets Among High-Risk Participants in an HIV Vaccine Trial. AIDS Res Hum Retroviruses. 2016;32:1143-1148 pubmed
flow cytometry; human; loading ...; fig 2a	Piepenbrink M, Samuel M, Zheng B, Carter B, Fucile C, Bunce C, et al. Humoral Dysregulation Associated with Increased Systemic Inflammation among Injection Heroin Users. PLoS ONE. 2016;11:e0158641 pubmed publisher
flow cytometry; human; loading ...; fig 2a	Malkiel S, Jeganathan V, Wolfson S, Manjarrez Orduno N, Marasco E, Aranow C, et al. Checkpoints for Autoreactive B Cells in the Peripheral Blood of Lupus Patients Assessed by Flow Cytometry. Arthritis Rheumatol. 2016;68:2210-20 pubmed publisher
flow cytometry; human; loading ...; fig 1c	James E, Gates T, LaFond R, Yamamoto S, Ni C, Mai D, et al. Neuroinvasive West Nile Infection Elicits Elevated and Atypically Polarized T Cell Responses That Promote a Pathogenic Outcome. PLoS Pathog. 2016;12:e1005375 pubmed publisher
flow cytometry; human; loading ...; fig 1	Gonzalez S, Taborda N, Correa L, Castro G, Hernandez J, Montoya C, et al. Particular activation phenotype of T cells expressing HLA-DR but not CD38 in GALT from HIV-controllers is associated with immune regulation and delayed progression to AIDS. Immunol Res. 2016;64:765-74 pubmed publisher
flow cytometry; human; fig 1d	Park C, Majeti R, Weissman I. In vivo evaluation of human hematopoiesis through xenotransplantation of purified hematopoietic stem cells from umbilical cord blood. Nat Protoc. 2008;3:1932-40 pubmed publisher
flow cytometry; human; fig 3	Jacobi A, Reiter K, Mackay M, Aranow C, Hiepe F, Radbruch A, et al. Activated memory B cell subsets correlate with disease activity in systemic lupus erythematosus: delineation by expression of CD27, IgD, and CD95. Arthritis Rheum. 2008;58:1762-73 pubmed publisher
flow cytometry; human	Diaz Blanco E, Bruns I, Neumann F, Fischer J, Graef T, Rosskopf M, et al. Molecular signature of CD34(+) hematopoietic stem and progenitor cells of patients with CML in chronic phase. Leukemia. 2007;21:494-504 pubmed
flow cytometry; human; fig 1	Kolar G, Mehta D, Pelayo R, Capra J. A novel human B cell subpopulation representing the initial germinal center population to express AID. Blood. 2007;109:2545-52 pubmed
flow cytometry; human	Kolar G, Mehta D, Wilson P, Capra J. Diversity of the Ig repertoire is maintained with age in spite of reduced germinal centre cells in human tonsil lymphoid tissue. Scand J Immunol. 2006;64:314-24 pubmed
flow cytometry; human; fig 3	Biedermann B, Gil D, Bowen D, Crocker P. Analysis of the CD33-related siglec family reveals that Siglec-9 is an endocytic receptor expressed on subsets of acute myeloid leukemia cells and absent from normal hematopoietic progenitors. Leuk Res. 2007;31:211-20 pubmed
flow cytometry; human	Jamieson C, Gotlib J, Durocher J, Chao M, Mariappan M, Lay M, et al. The JAK2 V617F mutation occurs in hematopoietic stem cells in polycythemia vera and predisposes toward erythroid differentiation. Proc Natl Acad Sci U S A. 2006;103:6224-9 pubmed
flow cytometry; human; tbl 1	Timeus F, Crescenzio N, Sanavio F, Fazio L, Doria A, Foglia L, et al. Multilineage engraftment of refrozen cord blood hematopoietic progenitors in NOD/SCID mice. Haematologica. 2006;91:369-72 pubmed
flow cytometry; human; fig 1A	Ninos J, Jefferies L, Cogle C, Kerr W. The thrombopoietin receptor, c-Mpl, is a selective surface marker for human hematopoietic stem cells. J Transl Med. 2006;4:9 pubmed
flow cytometry; human	Crough T, Burrows J, Fazou C, Walker S, Davenport M, Khanna R. Contemporaneous fluctuations in T cell responses to persistent herpes virus infections. Eur J Immunol. 2005;35:139-49 pubmed
flow cytometry; human	Ku C, Padilla J, Grose C, Butcher E, Arvin A. Tropism of varicella-zoster virus for human tonsillar CD4(+) T lymphocytes that express activation, memory, and skin homing markers. J Virol. 2002;76:11425-33 pubmed
flow cytometry; human; fig 2	Rutella S, Pierelli L, Bonanno G, Sica S, Ameglio F, Capoluongo E, et al. Role for granulocyte colony-stimulating factor in the generation of human T regulatory type 1 cells. Blood. 2002;100:2562-71 pubmed
flow cytometry; human; fig 2	Lewandowski D, Linassier C, Iochmann S, Degenne M, Domenech J, Colombat P, et al. Phosphatidylinositol 3-kinases are involved in the all-trans retinoic acid-induced upregulation of CD38 antigen on human haematopoietic cells. Br J Haematol. 2002;118:535-44 pubmed
flow cytometry; human	Basch R, Zhang X, Dolzhanskiy A, Karpatkin S. Expression of CD41 and c-mpl does not indicate commitment to the megakaryocyte lineage during haemopoietic development. Br J Haematol. 1999;105:1044-54 pubmed
flow cytometry; human	Luque R, Brieva J, Moreno A, Manzanal A, Escribano L, Villarrubia J, et al. Normal and clonal B lineage cells can be distinguished by their differential expression of B cell antigens and adhesion molecules in peripheral blood from multiple myeloma (MM) patients--diagnostic and clinical implications. Clin Exp Immunol. 1998;112:410-8 pubmed
flow cytometry; human	Denning Kendall P, Nicol A, Horsley H, Donaldson C, Bradley B, Hows J. Is in vitro expansion of human cord blood cells clinically relevant?. Bone Marrow Transplant. 1998;21:225-32 pubmed
	Heidt S, Hester J, Shankar S, Friend P, Wood K. B cell repopulation after alemtuzumab induction-transient increase in transitional B cells and long-term dominance of naÃ¯ve B cells. Am J Transplant. 2012;12:1784-92 pubmed publisher
	Morbach H, Wiegering V, Richl P, Schwarz T, Suffa N, Eichhorn E, et al. Activated memory B cells may function as antigen-presenting cells in the joints of children with juvenile idiopathic arthritis. Arthritis Rheum. 2011;63:3458-66 pubmed publisher

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product information

Product Type :

Antibody

Product Name :

CD38 Monoclonal Antibody (HIT2)

Catalog # :

MA1-19316

Quantity :

100 µg

Price :

US 410

Clonality :

Monoclonal

Purity :

protein A

Host :

Mouse

Reactivity :

Human

Applications :

Flow Cytometry: Assay Dependent, Immunohistochemistry (Frozen): Assay Dependent, Immunohistochemistry (Paraffin): 10 µg/mL, Western Blot: 2 µg/mL

Species :

Human

Clone :

Isotype :

IgG1

Storage :

4° C, do not freeze

Description :

CD38 (NAD+ glycohydrolase) is a type II transmembrane glycoprotein able to induce activation, proliferation and differentiation of mature lymphocytes and mediate apoptosis of myeloid and lymphoid progenitor cells. CD38 functions as a multi-catalytic ectoenzyme serving as ADP-ribosyl cyclase, cyclic ADP-ribose hydrolase and possibly NAD+ glycohydrolase or as a cell surface receptor. Antibodies to CD38 are useful in subtyping of lymphomas and leukemias, detection of plasma cells (i.e. identification of myelomas), and as a marker for activated B and T cells. CD38 participates in cell adhesion, signal transduction and calcium signaling. Further, CD38 is expressed at high levels in the pancreas, liver, kidney, malignant lymphoma and neuroblastoma. Diseases associated with CD38 dysfunction include chronic lymphocytic leukemia and Richter's Syndrome.

Immunogen :

Fetal human thymocytes.

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: Assay Dependent, Immunohistochemistry (Frozen): Assay Dependent, Immunohistochemistry (Paraffin): 10 µg/mL, Western Blot: 2 µg/mL

Aliases :

2'-phospho-ADP-ribosyl cyclase; 2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase; 2'-phospho-cyclic-ADP-ribose transferase; ADPRC 1; ADPRC1; ADP-ribosyl cyclase 1; ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1; cADPr hydrolase 1; Cd38; CD38 antigen; CD38 antigen (ADP-ribosyl cyclase / cyclic ADP-ribose hydrolase); CD38 antigen (p45); CD38 antigen p45; CD38 molecule; CD38H; Cd38-rs1; cluster of differentiation 38; cyclic ADP-ribose hydrolase 1; ecto-nicotinamide adenine dinucleotide glycohydrolase; I-19; NAD(+) nucleosidase; NAD+ nucleosidase; NIM-R5 antigen; T10

more info or order :

Invitrogen product webpage