CD1a Monoclonal Antibody (HI149) | Invitrogen MA1-19314 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

CD1a Monoclonal Antibody (HI149)

catalog :

MA1-19314

quantity :

100 µg

price :

US 241

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

HI149

reactivity :

human

application :

immunohistochemistry, flow cytometry, immunohistochemistry - frozen section

more info or order :

Invitrogen product webpage

citations: 6

Published Application/Species/Sample/Dilution	Reference
flow cytometry; human; loading ...; fig 1b	Kim J, Jeong J, Jung J, Jeon H, Lee S, Lim J, et al. Immunological characteristics and possible pathogenic role of urinary CD11c+ macrophages in lupus nephritis. Rheumatology (Oxford). 2020;: pubmed publisher
	Lin X, Zhuang X, Li C, Wang X. Interactions between dendritic cells and T lymphocytes in pathogenesis of nasal polyps. Exp Ther Med. 2018;15:5167-5172 pubmed publisher
	Jeffery H, McDowell P, Lutz P, Wawman R, Roberts S, Bagnall C, et al. Human intrahepatic ILC2 are IL-13positive amphiregulinpositive and their frequency correlates with model of end stage liver disease score. PLoS ONE. 2017;12:e0188649 pubmed publisher
	Betts R, Perkovic A, Mahapatra S, Del Bufalo A, Camara K, Howell A, et al. Contact sensitizers trigger human CD1-autoreactive T-cell responses. Eur J Immunol. 2017;47:1171-1180 pubmed publisher
	Nouri Shirazi M, Bible B, Zeng M, Tamjidi S, Bossart G. Phenotyping and comparing the immune cell populations of free-ranging Atlantic bottlenose dolphins (Tursiops truncatus) and dolphins under human care. BMC Vet Res. 2017;13:78 pubmed publisher
	Lopes D, Fernandes J, Cardoso T, Bafica A, Oliveira S, Carvalho E, et al. Dendritic cell profile induced by Schistosoma mansoni antigen in cutaneous leishmaniasis patients. Biomed Res Int. 2014;2014:743069 pubmed publisher

product information

Product Type :

Antibody

Product Name :

CD1a Monoclonal Antibody (HI149)

Catalog # :

MA1-19314

Quantity :

100 µg

Price :

US 241

Clonality :

Monoclonal

Purity :

protein A

Host :

Mouse

Reactivity :

Human

Applications :

Flow Cytometry: Assay Dependent, Immunohistochemistry (Frozen): Assay Dependent

Species :

Human

Clone :

HI149

Isotype :

IgG1

Storage :

4° C, do not freeze

Description :

CD1a is a non-polymorphic MHC Class 1 related cell surface glycoprotein, expressed in association with Beta 2 microglobulin. CD1a is expressed by cortical thymocytes, Langerhan's cells and by interdigitating cells. CD1a is also expressed by some malignancies of T cell lineage and in histiocytosis X. CD1a is expressed on cortical thymocytes, epidermal Langerhans cells, dendritic cells, on certain T-cell leukemias, and in various other tissues. CD1a is structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. CD1a localizes to the plasma membrane and recycles vesicles of the early endocytic system. At least five CD1 genes (CD1a, b, c, d, and e) are identified. Alternatively spliced transcript variants of CD1a have been observed, but their biological validity have not been determined.

Immunogen :

Human thymocytes.

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: Assay Dependent, Immunohistochemistry (Frozen): Assay Dependent

Aliases :

CD1; CD1a; CD1A antigen, a polypeptide; CD1a molecule; cluster of differentiation 1 A; cortical thymocyte antigen CD1A; differentiation antigen CD1-alpha-3; epidermal dendritic cell marker CD1a; FCB6; HTA1; hTa1 thymocyte antigen; R4; T6; T-cell surface antigen T6/Leu-6; T-cell surface glycoprotein CD1a

more info or order :

Invitrogen product webpage