PAG1 Monoclonal Antibody (PAG-C1) | Invitrogen MA1-19287 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

PAG1 Monoclonal Antibody (PAG-C1)

catalog :

MA1-19287

quantity :

100 µg

price :

US 389

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

PAG-C1

reactivity :

human, mouse, rat, bovine

application :

western blot, immunohistochemistry, immunoprecipitation, immunohistochemistry - paraffin section

more info or order :

Invitrogen product webpage

citations: 2

Published Application/Species/Sample/Dilution	Reference
western blot; rat; 1:800; fig 3	Fiore V, Strane P, Bryksin A, White E, Hagood J, Barker T. Conformational coupling of integrin and Thy-1 regulates Fyn priming and fibroblast mechanotransduction. J Cell Biol. 2015;211:173-90 pubmed publisher
	Foltz L, Palacios Moreno J, Mayfield M, Kinch S, Dillon J, Syrenne J, et al. PAG1 directs SRC-family kinase intracellular localization to mediate receptor tyrosine kinase-induced differentiation. Mol Biol Cell. 2020;31:2269-2282 pubmed publisher

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product information

Product Type :

Antibody

Product Name :

PAG1 Monoclonal Antibody (PAG-C1)

Catalog # :

MA1-19287

Quantity :

100 µg

Price :

US 389

Clonality :

Monoclonal

Purity :

protein A

Host :

Mouse

Reactivity :

Bovine, Human, Mouse, Rat

Applications :

Immunohistochemistry (Paraffin): Assay Dependent, Immunoprecipitation: Assay Dependent, Western Blot: Assay-Dependent

Species :

Bovine, Human, Mouse, Rat

Clone :

PAG-C1

Isotype :

IgG2b

Storage :

4° C, do not freeze

Description :

PAG (phosphoprotein associated with GEMs), also known as Cbp (Csk-binding protein), is a ubiquitously expressed 46 kDa transmembrane adaptor protein present in membrane rafts (glycosphingolipid-enriched microdomains), which however migrates on SDS PAGE gels anomalously as an 80 kDa molecule. Following tyrosine phosphorylation by Src family kinases, PAG binds and thereby activates the protein tyrosine kinase Csk, the major negative regulator of the Src family kinases. Signaling via the B-cell receptor in B cells or high affinity IgE receptor (FcepsilonRI) in mast cells leads to PAG increased tyrosine phosphorylation and Csk binding, while T cell receptor signaling causes PAG dephosphorylation, loss of Csk binding and increased activation of the protein tyrosine kinase Lck.

Immunogen :

C-terminal peptide (last 15 amino acids) of human Csk binding protein coupled to KLH

Format :

Liquid

Applications w/Dilutions :

Immunohistochemistry (Paraffin): Assay Dependent, Immunoprecipitation: Assay Dependent, Western Blot: Assay-Dependent

Aliases :

Cbp; Csk binding protein; csk-binding protein; F730007C19Rik; Pag; PAG 1; PAG1; PAG1B; phosphoprotein associated with glycosphingolipid microdomains 1; phosphoprotein associated with glycosphingolipid-enriched microdomains 1; phosphoprotein membrane anchor with glycosphingolipid microdomains 1; phosphoprotein transmembrane adaptor 1; phosphoprotein-associated with GEMs; pregnancy-associated glycoprotein 1; Pregnancy-specific protein B; PSP-B; similar to pregnancy-associated glycoprotein 1; transmembrane adapter protein PAG; transmembrane adaptor protein PAG; transmembrane phosphoprotein Cbp

more info or order :

Invitrogen product webpage